2. Gene
  3. USP13 - ubiquitin specific peptidase 13 Gene

USP13 - ubiquitin specific peptidase 13 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素特异性肽酶 13

种属: Homo sapiens

同用名: ISOT3; IsoT-3

基因 ID: 8975 | 基因类型: protein coding

关于 USP13

Cytogenetic location: 3q26.33 Genomic coordinates (GRCh38): 3:179,653,040-179,789,401 (from NCBI)

This gene has 73 transcripts (splice variants), 207 orthologues and 71 paralogues. Broad expression in heart (RPKM 16.6), adrenal (RPKM 7.5) and 21 other tissues.

功能概要

启用多项功能，包括 BAT3 复杂绑定活动；伴侣结合活动；和半胱氨酸型肽酶活性。涉及多个过程，包括维持参与 ERAD 通路的未折叠蛋白；调节细胞分解代谢过程；和转录调控，DNA 模板化。作用于蛋白质去泛素化和蛋白质稳定化的上游或内部。预测位于核质中。预计在胞质溶胶和细胞核中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including BAT3 complex binding activity; chaperone binding activity; and cysteine-type peptidase activity. Involved in several processes, including maintenance of unfolded protein involved in ERAD pathway; regulation of cellular catabolic process; and regulation of transcription, DNA-templated. Acts upstream of or within protein deubiquitination and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP13 基因产物(1)

mRNA Protein Name
NM_003940.3 NP_003931.2 ubiquitin carboxyl-terminal hydrolase 13
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BAT3 complex binding IDA
IDA: 通过直接分析推断
24424410 GOA
enables K48-linked deubiquitinase activity IMP
IMP: 通过突变表型推断
24424410 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
21811243 GOA
enables cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
21811243 GOA
enables proteasome binding IDA
IDA: 通过直接分析推断
24424410 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21811243 GOA
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
24424410 GOA
enables ubiquitin binding IDA
IDA: 通过直接分析推断
21659512 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
21659512 GOA
enables ubiquitin-like protein ligase binding IPI
IPI: 通过物理相互作用推断
24424410 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell population proliferation IMP
IMP: 通过突变表型推断
21811243 GOA
involved in maintenance of unfolded protein IMP
IMP: 通过突变表型推断
24424410 GOA
involved in positive regulation of ERAD pathway IMP
IMP: 通过突变表型推断
24424410 GOA
acts upstream of or within protein K29-linked deubiquitination IDA
IDA: 通过直接分析推断
26280536 GOA
acts upstream of or within protein K6-linked deubiquitination IDA
IDA: 通过直接分析推断
26280536 GOA
acts upstream of or within protein K63-linked deubiquitination IDA
IDA: 通过直接分析推断
26280536 GOA
involved in protein K63-linked deubiquitination IDA
IDA: 通过直接分析推断
22216260 GOA
acts upstream of or within protein stabilization IDA
IDA: 通过直接分析推断
26280536 GOA
involved in protein stabilization IDA
IDA: 通过直接分析推断
21659512 GOA
acts upstream of or within protein stabilization IMP
IMP: 通过突变表型推断
26280536 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
21811243 GOA
involved in regulation of autophagy IDA
IDA: 通过直接分析推断
21962518 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

USP13 蛋白结构

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (211 - 283)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (335 - 858)

UBA

UBA: UBA/TS-N domain (653 - 690)

UBA

UBA: UBA/TS-N domain (729 - 764)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 863 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 13

deubiquitinating enzyme 13

关联疾病

疾病名称 别名
Fetal Adenoma

Microfollicular Adenoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12990 Spautin-1 99.27% 否
HY-RS15524 USP13 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris USP13 VGNC VGNC:49638
Macaca mulatta USP13 VGNC VGNC:78735
Felis catus USP13 VGNC VGNC:66867
Rattus norvegicus USP13 RGD RGD:1306044
Bos taurus USP13 VGNC VGNC:52841
Mus musculus USP13 MGD MGI:1919857
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