2. Gene
  3. MYOZ1 - myozenin 1 Gene

MYOZ1 - myozenin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌增生素 1

种属: Homo sapiens

同用名: CS-2; FATZ; MYOZ

基因 ID: 58529 | 基因类型: protein coding

关于 MYOZ1

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,631,612-73,641,474 (from NCBI)

This gene has 1 transcript (splice variant), 275 orthologues and 2 paralogues. Biased expression in esophagus (RPKM 24.9), prostate (RPKM 22.9) and 4 other tissues.

功能概要

该基因编码的蛋白质主要在骨骼肌中表达，属于肌增蛋白家族。这个家族的成员作为钙调神经磷酸酶相互作用蛋白发挥作用，帮助将钙调神经磷酸酶连接到心肌和骨骼肌的肌节。它们在神经钙蛋白信号转导的调节中发挥重要作用。[RefSeq 提供，2012 年 4 月]

The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether Calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of Calcineurin signaling. [provided by RefSeq, Apr 2012]

MYOZ1 基因产物(1)

mRNA Protein Name
NM_021245.4 NP_067068.1 myozenin-1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables FATZ binding IDA
IDA: 通过直接分析推断
10984498 GOA
enables actinin binding EXP
EXP: 通过实验结果推断
34049882 GOA
enables actinin binding IMP
IMP: 通过突变表型推断
34049882 GOA
enables actinin binding IPI
IPI: 通过物理相互作用推断
34049882 GOA
enables molecular condensate scaffold activity IDA
IDA: 通过直接分析推断
34049882 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10427098 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYOZ1 蛋白结构

Calsarcin

Calsarcin: Calcineurin-binding protein (Calsarcin) (1 - 299)

  • 0
  • 100
  • 200
  • 299 a.a.
蛋白主名 其他名称

myozenin-1

calsarcin-2

MYOZ1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MYOZ1 Q9NP98 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 KRT34 Homo sapiens O76011
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
种属内
MYOZ1 Q9NP98 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
种属内
MYOZ1 Q9NP98 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 ACTN3 Homo sapiens Q08043
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 ACTN3 Homo sapiens Q08043
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 BAG4 Homo sapiens O95429
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 ACTN1 Homo sapiens P12814
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 ACTN1 Homo sapiens P12814
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 VBP1 Homo sapiens P61758
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 VBP1 Homo sapiens P61758
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
种属内
MYOZ1 Q9NP98 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 CEACAM6 Homo sapiens P40199
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 CEACAM6 Homo sapiens P40199
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 TRIM63 Homo sapiens Q969Q1
Pull Down
18157088
种属内
MYOZ1 Q9NP98 EIF3F Homo sapiens O00303
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 EIF3F Homo sapiens O00303
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 WASHC3 Homo sapiens Q9Y3C0
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
32296183
种属内
MYOZ1 Q9NP98 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 TRIM23 Homo sapiens P36406
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 CRX Homo sapiens O43186
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 CRX Homo sapiens O43186
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
种属内
MYOZ1 Q9NP98 FLNA Homo sapiens P21333-2
Validated Y2H
32814053
种属内
MYOZ1 Q9NP98 FLNA Homo sapiens P21333-2
Y2H Prey Pooling
32296183
种属内
MYOZ1 Q9NP98 FLNA Homo sapiens P21333-2
Y2H Array
32814053
种属内
MYOZ1 Q9NP98 FLNA Homo sapiens P21333-2
Y2H Pooling
32814053
种属内
MYOZ1 Q9NP98 FLNA Homo sapiens P21333-2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Myopathy, Myofibrillar, 4

Myofibrillar Myopathy 4

MFM4

Zaspopathy

Myopathy, Myofibrillar, Zasp-Related
Myopathy, Spheroid Body

Spheroid Body Myopathy

Autosomal Dominant Spheroid Body Myopathy

SBM
Myopathy, Myofibrillar, 3

Myotilinopathy

Myofibrillar Myopathy 3

MFM3

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1a

Lgmd1a

Muscular Dystrophy, Limb-Girdle, Type 1a

Myopathy, Myofibrillar, Myotilin-Related

Muscular Dystrophy, Limb-Girdle, Type 1, Formerly

Lgmd1, Formerly

Muscular Dystrophy, Limb-Girdle, Type 1a, Formerly

Lgmd1a, Formerly

Qualitative Or Quantitative Defects Of Myotilin

Limb-Girdle Muscular Dystrophy Due To Myotilin Deficiency

Distal Myotilinopathy

Lgmd1

Limb-Girdle Muscular Dystrophy 1a

Mfm Myotilin-Related

Muscular Dystrophy, Limb-Girdle, Type 1

Myopathy Myofibrillar Myotylin-Related

Myopathy, Myofibrillar, Type 3
Myopathy, Myofibrillar, 5

Myofibrillar Myopathy 5

MFM5

Myopathy, Myofibrillar, Filamin C-Related

Filaminopathy, Autosomal Dominant

Filaminopathy

Muscle Filaminopathy

Autosomal Dominant Filaminopathy

Mfm Filamin C-Related

Myopathy Myofibrillar Filamin C-Related

Myopathy, Myofibrillar, Type 5
Myofibrillar Myopathy

Desmin Related Myopathy

Myotilinopathy

Myopathy, Myofibrillar

Alpha Beta Crystallinopathy

Desmin Storage Myopathy

Desminopathy

Filaminopathy

Protein Surplus Myopathy

Zaspopathy

Myofibrillar Myopathies

Myopathy, Myofibrillar, Desmin-Related

Myopathy, Desmin Storage

Mfm - [Myofibrillar Myopathy]
Cardiomyopathy, Dilated, 3b

Dilated Cardiomyopathy 3b

CMD3B

X-Linked Dilated Cardiomyopathy

Xlcm

Dmd-Associated Dilated Cardiomyopathy

Cardiomyopathy, Dilated, X-Linked

Dmd-Related Dilated Cardiomyopathy

Xldc

Cardiomyopathy, Dilated, X-Linked 3b

Cardiomyopathy, Dilated, Type 3b
Postural Orthostatic Tachycardia Syndrome

Irritable Heart

Mitral Valve Prolapse Syndrome

Neurocirculatory Asthenia

Orthostatic Intolerance Due To Net Deficiency

Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency

Orhtostatic Intolerance

Postural Tachycardia Syndrome Due To Net Deficiency

Soldiers Heart
Myopathy

Muscular Diseases

Myopathies
Left Ventricular Noncompaction

Noncompaction Cardiomyopathy

Left Ventricular Hypertrabeculation

Lvnc

Spongy Myocardium

Isolated Noncompaction Of The Ventricular Myocardium

Left Ventricular Myocardial Noncompaction Cardiomyopathy

Fetal Myocardium

Honeycomb Myocardium

Hypertrabeculation Syndrome

Left Ventricular Non-Compaction

Lvht

Non-Compaction Of The Left Ventricular Myocardium

Ventricular Noncompaction, Left

Non-Compaction Cardiomyopathy
Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy

Familial Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy 1

CMH1

Hypertrophic Cardiomyopathy 19

CMH

Ventricular Hypertrophy, Hereditary

Ash

Hypertrophic Subaortic Stenosis, Idiopathic

Cardiomyopathy, Familial Hypertrophic

Cardiomyopathy, Hypertrophic, 1, Digenic

Cardiomyopathy, Familial Hypertrophic 1

Hcm

Hereditary Ventricular Hypertrophy

Idiopathic Hypertrophic Subaortic Stenosis

Hypertrophic Cardiomyopathy

Cardiomyopathy, Hypertrophic, Familial

Cardiomyopathy, Hypertrophic, 1

Familial Asymmetric Septal Hypertrophy

Heritable Hypertrophic Cardiomyopathy

Fhc

Cardiomyopathy, Hypertrophic, Familial, Type 1
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08965 MYOZ1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MYOZ1 VGNC VGNC:63693
Rattus norvegicus MYOZ1 RGD RGD:1561064
Bos taurus MYOZ1 VGNC VGNC:31840
Macaca mulatta MYOZ1 VGNC VGNC:74951
Mus musculus MYOZ1 MGD MGI:1929471
Canis familiaris MYOZ1 VGNC VGNC:43583
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