TRAF1 - TNF receptor associated factor 1 Gene

中文名称：TNF 受体相关因子 1

种属: Homo sapiens

同用名: EBI6; MGC:10353

关于 TRAF1

功能概要

该基因编码的蛋白质是肿瘤坏死因子受体 (TNFR) 相关因子 (TRAF) 蛋白质家族的成员。 TRAF 蛋白与 TNFR 超家族的各种受体结合并介导信号转导。这种蛋白质和 TRAF2 形成异二聚体复合物，这是 TNF-α 介导的 MAPK8/JNK 和 NF-kappaB 激活所必需的。由该蛋白和 TRAF2 形成的蛋白复合物还与凋亡抑制蛋白 (IAP) 相互作用，从而介导来自 TNF 受体的抗凋亡信号。该蛋白的表达可由爱泼斯坦-巴尔病毒 (EBV) 诱导。发现 EBV 感染膜蛋白 1 (LMP1) 与该蛋白和其他 TRAF 蛋白相互作用；这种相互作用被认为将 LMP1 介导的 B 淋巴细胞转化与 TNFR 家族受体的信号转导联系起来。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2010 年 7 月]

The protein encoded by this gene is a member of the TNF Receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV Infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]