2. Gene
  3. DEPTOR - DEP domain containing MTOR interacting protein Gene

DEPTOR - DEP domain containing MTOR interacting protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 DEP 结构域 MTOR 相互作用蛋白

种属: Homo sapiens

同用名: DEP.6; DEPDC6

基因 ID: 64798 | 基因类型: protein coding

关于 DEPTOR

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,873,722-120,050,918 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 29.3), adrenal (RPKM 13.7) and 17 other tissues.

功能概要

参与多个过程，包括 TOR 信号的负调控；细胞大小的负调节；蛋白激酶活性的负调节。 [由基因组资源联盟提供，2022 年 4 月]

Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. [provided by Alliance of Genome Resources, Apr 2022]

DEPTOR 基因产物(2)

mRNA Protein Name
NM_001283012.2 NP_001269941.1 DEP domain-containing mTOR-interacting protein isoform 2
NM_022783.4 NP_073620.2 DEP domain-containing mTOR-interacting protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidic acid binding IDA
IDA: 通过直接分析推断
25936805 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19446321 GOA
enables protein kinase inhibitor activity IDA
IDA: 通过直接分析推断
22017875 GOA
enables protein serine/threonine kinase inhibitor activity IDA
IDA: 通过直接分析推断
22017875 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of TOR signaling IMP
IMP: 通过突变表型推断
19446321 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
22017875 GOA
involved in negative regulation of TORC1 signaling IGI
IGI: 通过遗传相互作用推断
33110214 GOA
involved in negative regulation of TORC2 signaling IDA
IDA: 通过直接分析推断
25936805 GOA
involved in negative regulation of TORC2 signaling IGI
IGI: 通过遗传相互作用推断
33110214 GOA
involved in negative regulation of cell size IMP
IMP: 通过突变表型推断
19446321 GOA
involved in negative regulation of protein kinase activity IMP
IMP: 通过突变表型推断
19446321 GOA
involved in positive regulation of autophagy IDA
IDA: 通过直接分析推断
22017875 GOA
involved in regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
19446321 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in lysosomal membrane IDA
IDA: 通过直接分析推断
25936805 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DEPTOR 蛋白结构

DEP

DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (50 - 117)

DEP

DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (151 - 217)

  • 0
  • 100
  • 200
  • 300
  • 409 a.a.
蛋白主名 其他名称

DEP domain-containing mTOR-interacting protein

DEP domain containing 6

DEPTOR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DEPTOR Q8TB45 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra DEPTOR Q8TB45 ANKRD11 Homo sapiens X5D778
Y2H Array
32296183
Intra DEPTOR Q8TB45 ANKRD11 Homo sapiens X5D778
Y2H Prey Pooling
32296183
Intra DEPTOR Q8TB45 CCDC110 Homo sapiens Q8TBZ0
Y2H Prey Pooling
25416956
Intra DEPTOR Q8TB45 CCDC110 Homo sapiens Q8TBZ0
Validated Y2H
25416956
Intra DEPTOR Q8TB45 CCDC110 Homo sapiens Q8TBZ0
Y2H Array
25416956
Intra DEPTOR Q8TB45 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra DEPTOR Q8TB45 MTOR Homo sapiens P42345
Anti Bait CoIP
19446321
Intra DEPTOR Q8TB45 MTOR Homo sapiens P42345
Anti Tag CoIP
19446321
Cross DEPTOR Q8TB45 Mtor Rattus norvegicus P42346
Anti Tag CoIP
19446321
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Subependymal Glioma

Mixed Subependymoma-Ependymoma

Subependymal Astrocytoma

Who Grade I Ependymal Tumor

Glioma, Subependymal
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-132902 DEPTOR-IN-1 Inhibitor 99.09% 否
HY-RS03697 DEPTOR Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-164385 NSC126405 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DEPTOR VGNC VGNC:28008
Mus musculus DEPTOR MGD MGI:2146322
Macaca mulatta DEPTOR VGNC VGNC:71691
Canis familiaris DEPTOR VGNC VGNC:39900
Felis catus DEPTOR VGNC VGNC:61446
Rattus norvegicus DEPTOR RGD RGD:1561030
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