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  4. DEPTOR-IN-1

DEPTOR-IN-1 是一种新的潜在的 DEPTOR 抑制剂，其 Kd 值为 9.3 μM。

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DEPTOR-IN-1 Chemical Structure

DEPTOR-IN-1 Chemical Structure

CAS No. : 2615911-12-9

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规格 价格 是否有货 数量
1 mg ￥1485
In-stock
5 mg ￥3650
In-stock
10 mg ￥5400
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

DEPTOR-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DEPTOR-IN-1 is a novel putative DEPTOR inhibitor with a Kd value of 9.3 μM.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DLD-1 IC50
10 μM
Compound: C3
Antiproliferative activity against human DLD1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human DLD1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
HepG2 IC50
> 10 μM
Compound: C3
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
HL-60 IC50
6.6 μM
Compound: C3
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
MCF7 IC50
8.68 μM
Compound: C3
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
MGC-803 IC50
> 10 μM
Compound: C3
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
MOLT-4 IC50
7.02 μM
Compound: C3
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
NCI-H460 IC50
> 10 μM
Compound: C3
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
RPMI-8226 IC50
1.09 μM
Compound: C3
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
SiHa IC50
> 10 μM
Compound: C3
Antiproliferative activity against human SiHa cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human SiHa cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
U-251 IC50
> 10 μM
Compound: C3
Antiproliferative activity against human U251 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human U251 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
U-266 IC50
1.11 μM
Compound: C3
Antiproliferative activity against human U266 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human U266 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
U2OS IC50
> 10 μM
Compound: C3
Antiproliferative activity against human U2OS cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human U2OS cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 34644502]
分子量

472.29

Formula

C24H16Cl2FNO4
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 4 mg/mL (8.47 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1173 mL 10.5867 mL 21.1734 mL
5 mM 0.4235 mL 2.1173 mL 4.2347 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    90% Corn Oil

    Solubility: ≥ 0.4 mg/mL (0.85 mM); 澄清溶液

    此方案可获得 ≥ 0.4 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。

    以 1 mL 工作液为例，取 100 μL 4.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
请输入您的动物体内配方组成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
连续给药周期超过半月以上，请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
纯度 & 产品资料
参考文献

DEPTOR-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1173 mL 10.5867 mL 21.1734 mL 52.9336 mL
5 mM 0.4235 mL 2.1173 mL 4.2347 mL 10.5867 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DEPTOR-IN-12615911-12-9OthersInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-132902
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