1. Gene
  2. Mtor - mechanistic target of rapamycin kinase Gene

Mtor - mechanistic target of rapamycin kinase Gene

中文名称:雷帕霉素激酶的机制靶点

种属: Rattus norvegicus

同用名: Frap1; RAFT1

基因 ID: 56718 | 基因类型: protein coding

关于 Mtor

Primary_assembly 5: 158,884,804-158,994,311 forward strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 217 orthologues, 5 paralogues and is associated with 102 phenotypes. Biased expression in Kidney (RPKM 158.6), Heart (RPKM 127.5) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多种功能,包括蛋白激酶结合活性;蛋白丝氨酸/苏氨酸激酶活性;和翻译调节活动。参与多个过程,包括细胞群增殖的正向调节;调节细胞蛋白质代谢过程;和肌肉适应的调节。在细胞投射组织的上游或内部起作用,并对细胞大小进行负调节。位于细胞质和细胞核中。 TORC1 复合体的一部分。在谷氨酸能突触和突触后细胞质中活跃。与树突和神经细胞体共定位。用于研究多种疾病,包括动脉疾病(多种);脑部疾病(多种);新月体性肾小球肾炎;肾功能衰竭(多发);和肌肉萎缩。多种疾病的生物标志物,包括大脑中动脉梗塞;肥胖; 2型糖尿病;输尿管梗阻;和血管性痴呆。该基因的人类直系同源物与常染色体显性多囊肾病有关;肾血管平滑肌脂肪瘤;肺部疾病(多发);前列腺癌;和 2 型糖尿病。与人 mTOR 同源(雷帕霉素激酶的机制靶标)。 [由基因组资源联盟提供,2022 年 4 月]

Enables several functions, including protein kinase binding activity; protein serine/threonine kinase activity; and translation regulator activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of cellular protein metabolic process; and regulation of muscle adaptation. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in cytosol and nucleus. Part of TORC1 complex. Is active in glutamatergic synapse and postsynaptic cytosol. Colocalizes with dendrite and neuronal cell body. Used to study several diseases, including artery disease (multiple); brain disease (multiple); crescentic glomerulonephritis; kidney failure (multiple); and muscular atrophy. Biomarker of several diseases, including middle cerebral artery infarction; obesity; type 2 diabetes mellitus; ureteral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human mTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mtor 基因产物(1)

mRNA Protein Name
NM_019906.2 NP_063971.1 serine/threonine-protein kinase mTOR
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15525761 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
11853878 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
24583056 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
17142137 RGD
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
15388509 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell projection organization IGI
IGI: 通过遗传相互作用推断
16286931 RGD
involved in long-term memory IMP
IMP: 通过突变表型推断
24076274 RGD
involved in mRNA stabilization IMP
IMP: 通过突变表型推断
21073857 RGD
involved in maternal process involved in female pregnancy IDA
IDA: 通过直接分析推断
19589861 RGD
involved in negative regulation of autophagy IMP
IMP: 通过突变表型推断
24725502 RGD
acts upstream of or within negative regulation of cell size IMP
IMP: 通过突变表型推断
16286931 RGD
involved in negative regulation of cholangiocyte apoptotic process IMP
IMP: 通过突变表型推断
24498161 RGD
involved in negative regulation of iodide transmembrane transport IMP
IMP: 通过突变表型推断
20392814 RGD
involved in negative regulation of muscle atrophy IMP
IMP: 通过突变表型推断
19260063 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
21357504 RGD
involved in negative regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
21357504 RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development IMP
IMP: 通过突变表型推断
21318349 RGD
involved in positive regulation of cellular senescence IMP
IMP: 通过突变表型推断
19698731 RGD
involved in positive regulation of cholangiocyte proliferation IMP
IMP: 通过突变表型推断
24498161 RGD
involved in positive regulation of dendritic spine development IMP
IMP: 通过突变表型推断
21683721 RGD
involved in positive regulation of eating behavior IMP
IMP: 通过突变表型推断
23955309 RGD
involved in positive regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
17110594 RGD
involved in positive regulation of epithelial cell apoptotic process IMP
IMP: 通过突变表型推断
21779001 RGD
involved in positive regulation of glial cell proliferation IMP
IMP: 通过突变表型推断
19576187 RGD
involved in positive regulation of granulosa cell proliferation IMP
IMP: 通过突变表型推断
22383759 RGD
involved in positive regulation of neurogenesis IMP
IMP: 通过突变表型推断
19474323 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
19474323 RGD
involved in positive regulation of neuron maturation IMP
IMP: 通过突变表型推断
24118019 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
22705730 RGD
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
19576187 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
19439614 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
17110594 RGD
involved in positive regulation of skeletal muscle hypertrophy IMP
IMP: 通过突变表型推断
23470307 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
19589861 RGD
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
15525761 RGD
involved in protein autophosphorylation IMP
IMP: 通过突变表型推断
15388509 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
17142137 RGD
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
17110594 RGD
involved in regulation of brown fat cell differentiation IMP
IMP: 通过突变表型推断
20133456 RGD
involved in regulation of carbohydrate metabolic process IDA
IDA: 通过直接分析推断
17142137 RGD
involved in regulation of carbohydrate metabolic process IMP
IMP: 通过突变表型推断
17142137 RGD
involved in regulation of carbohydrate utilization IDA
IDA: 通过直接分析推断
17142137 RGD
involved in regulation of carbohydrate utilization IMP
IMP: 通过突变表型推断
17142137 RGD
involved in regulation of fatty acid beta-oxidation IDA
IDA: 通过直接分析推断
17142137 RGD
involved in regulation of fatty acid beta-oxidation IMP
IMP: 通过突变表型推断
17142137 RGD
involved in regulation of glycogen biosynthetic process IDA
IDA: 通过直接分析推断
17142137 RGD
involved in regulation of glycogen biosynthetic process IMP
IMP: 通过突变表型推断
17142137 RGD
involved in regulation of response to food IDA
IDA: 通过直接分析推断
16690869 RGD
involved in regulation of response to food IMP
IMP: 通过突变表型推断
16690869 RGD
involved in regulation of translation at synapse, modulating synaptic transmission EXP
EXP: 通过实验结果推断
15525761 RGD
involved in regulation of translation at synapse, modulating synaptic transmission IDA
IDA: 通过直接分析推断
15525761 RGD
involved in regulation of translation at synapse, modulating synaptic transmission IEP
IEP: 通过表达模式推断
15525761 RGD
involved in regulation of translation at synapse, modulating synaptic transmission IMP
IMP: 通过突变表型推断
15525761 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
28536139 RGD
involved in response to cocaine IMP
IMP: 通过突变表型推断
20977929 RGD
involved in social behavior IMP
IMP: 通过突变表型推断
23027611 RGD
involved in spinal cord development IDA
IDA: 通过直接分析推断
23681769 RGD
involved in visual learning IMP
IMP: 通过突变表型推断
20599569 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of TORC1 complex IDA
IDA: 通过直接分析推断
17110594 RGD
located in dendrite IDA
IDA: 通过直接分析推断
15525761 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
11756682 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15525761 RGD
is active in postsynaptic cytosol IDA
IDA: 通过直接分析推断
11756682 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
7822316 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Mtor 蛋白结构

TEL1

TEL1: COG5032 (362 - 2548)

HEAT

HEAT: sd00044 (654 - 680)

HEAT

HEAT: sd00044 (690 - 720)

HEAT

HEAT: sd00044 (728 - 758)

HEAT

HEAT: sd00044 (771 - 804)

HEAT

HEAT: sd00044 (816 - 846)

HEAT

HEAT: sd00044 (954 - 980)

HEAT

HEAT: sd00044 (992 - 1020)

HEAT

HEAT: sd00044 (1032 - 1061)

HEAT

HEAT: sd00044 (1072 - 1098)

HEAT

HEAT: sd00044 (1110 - 1141)

HEAT

HEAT: sd00044 (1153 - 1179)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2549 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase mTOR

FK506 binding protein 12-rapamycin associated protein 1

FK506-binding protein 12-rapamycin complex-associated protein 1

FKBP12-rapamycin complex-associated protein

RAPT1

mammalian target of rapamycin

mechanistic target of rapamycin (serine/threonine kinase)

rapamycin and FKBP12 target-1 protein

rapamycin target protein 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mtor NCBI NCBI:2475