2. Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage PI3K/Akt/mTOR Apoptosis Epigenetics
  3. Src ATM/ATR Apoptosis mTOR AMPK
  4. AD1058

AD1058 是一种具有口服活性、选择性和血脑屏障通透性的 ATR 抑制剂 (IC50 = 1.6 nM)。AD1058 具有体内抗癌活性，能抑制细胞增殖、破坏细胞周期和诱导细胞凋亡 (Apoptosis)。AD1058 可以用于晚期实体瘤引起的脑和中枢神经系统转移的研究。

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AD1058 Chemical Structure

AD1058 Chemical Structure

CAS No. : 2907782-78-7

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AD1058 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

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Lck Fyn Blk

查看 ATM/ATR 亚型特异性产品:

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ATM ATR

查看 mTOR 亚型特异性产品:

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mTOR mTORC1 mTORC2

查看 AMPK 亚型特异性产品:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AD1058 is an orally active, selective, and blood-brain barrier permeable inhibitor of ATR. AD1058 exhibits in vivo anticancer activity, inhibiting cell proliferation, disrupting the cell cycle, and inducing Apoptosis. AD1058 can be utilized in research on brain and central nervous system metastases stemming from advanced solid tumors[1].

IC50 & Target

ATR

1.6 nM (IC50)

mTOR

45.83 nM (IC50)

ARK5

7314.00 nM (IC50)

LCK

2594.00 nM (IC50)

分子量

412.47

Formula

C19H20N6O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AD1058 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AD10582907782-78-7AD 1058AD-1058SrcATM/ATRApoptosismTORAMPKAtaxia telangiectasia mutatedATM and RAD3 relatedMammalian target of RapamycinAMP-activated protein kinaseblood-brain barrier (BBB)apoptosissolid tumorsA2780OCI-Ly10LoVoHCT116H446HT-29SU-DHL4DLD1Capan-1PC-3Inhibitorinhibitorinhibit

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