2. Apoptosis
  3. Caspase
  4. N1,N11-Diethylnorspermine

N1,N11-Diethylnorspermine (DENSPM) 是一种有效的抗癌剂。N1,N11-Diethylnorspermine 是一种激活多胺分解代谢的精胺类似物。N1,N11-Diethylnorspermine 诱导线粒体释放细胞色素 c，导致 caspase 3 的激活。N1,N11-Diethylnorspermine 通过诱导亚精胺/精胺 N1- 乙酰转移酶 (SSAT) 结合产生过氧化氢杀灭多形胶质母细胞瘤 (GBM) 细胞。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

N1,N11-Diethylnorspermine Chemical Structure

N1,N11-Diethylnorspermine Chemical Structure

CAS No. : 121749-39-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

N1,N11-Diethylnorspermine 的其他形式现货产品:

Customer Review

Other Forms of N1,N11-Diethylnorspermine:

N1,N11-Diethylnorspermine 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N1,N11-Diethylnorspermine (DENSPM) is a potent anticancer agent. N1,N11-Diethylnorspermine is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production[1][2][3].

IC50 & Target

Caspase 3

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
B16 IC50
> 40 μM
Compound: BENSpm
Cytotoxicity against mouse B16 cells assessed as induction of cell death incubated for 24 hrs by MTT assay
Cytotoxicity against mouse B16 cells assessed as induction of cell death incubated for 24 hrs by MTT assay
[PMID: 36399911]
Jurkat IC50
0.65 μM
Compound: DENSPM
inhibitory activity against growth of JURKAT cells after 144h.
inhibitory activity against growth of JURKAT cells after 144h.
[PMID: 9748365]
KB 3-1 IC50
> 40 μM
Compound: BENSpm
Cytotoxicity against human KB-3-1 cells assessed as induction of cell death incubated for 24 hrs by MTT assay
Cytotoxicity against human KB-3-1 cells assessed as induction of cell death incubated for 24 hrs by MTT assay
[PMID: 36399911]
L1210 IC50
> 100 μM
Compound: 3
In vitro inhibition of L1210 growth after 48 hours.
In vitro inhibition of L1210 growth after 48 hours.
[PMID: 7932575]
L1210 IC50
2 μM
Compound: DENSPM
Growth inhibition of L1210 cells was measured in the presence of nine different concentrations: 0,0.03,0.1,0.3,1,3,10,30, and 100 uM after 96 hours
Growth inhibition of L1210 cells was measured in the presence of nine different concentrations: 0,0.03,0.1,0.3,1,3,10,30, and 100 uM after 96 hours
[PMID: 10649978]
L1210 IC50
2 μM
Compound: 3
In vitro inhibition of L1210 growth after 96 hours.
In vitro inhibition of L1210 growth after 96 hours.
[PMID: 7932575]
L1210 IC50
20 μM
Compound: DENSPM
Growth inhibition of L1210 cells was measured in the presence of nine different concentrations: 0,0.03,0.1,0.3,1,3,10,30, and 100 uM after 48 hours
Growth inhibition of L1210 cells was measured in the presence of nine different concentrations: 0,0.03,0.1,0.3,1,3,10,30, and 100 uM after 48 hours
[PMID: 10649978]
MCF7 IC50
> 40 μM
Compound: BENSpm
Cytotoxicity against human MCF7 cells assessed as induction of cell death incubated for 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as induction of cell death incubated for 24 hrs by MTT assay
[PMID: 36399911]
体内研究
(In Vivo)

N1,N11-Diethylnorspermine (40 mg/kg, three times per day for two cycles of 6 days) clearly prevents tumor growth in mice bearing xenografts of the DU-145 cell line[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

244.42

Formula

C13H32N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

N1,N11-Diethylnorspermine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N1,N11-Diethylnorspermine121749-39-1Caspaseprostate cancerPC-3TSU-pr1DU-145JCA-1spermine analoguebreast cancerGBM cellglioblastoma multiformeInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
N1,N11-Diethylnorspermine
目录号：
HY-13610
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z