2. Autophagy PI3K/Akt/mTOR Apoptosis Metabolic Enzyme/Protease
  3. PINK1/Parkin mTOR Apoptosis Prolyl Endopeptidase (PREP)
  4. Salidroside

Salidroside  (Synonyms: 红景天苷; Rhodioloside)

目录号: HY-N0109 纯度: 99.90%
COA 产品使用指南

摩尔计算器

Salidroside (Rhodioloside) 是一种脯氨酰内肽酶 (prolyl endopeptidase) 抑制剂。Salidroside 可通过激活 mTOR 信号缓解肿瘤恶病质小鼠模型中的恶病质症状。Salidroside 还能通过增强 PINK1/Parkin 介导的线粒体自噬来保护多巴胺能神经元。

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Salidroside Chemical Structure

Salidroside Chemical Structure

CAS No. : 10338-51-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥605
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1 mg ￥250
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5 mg ￥550
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10 mg ￥880
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100 mg   询价  

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Customer Review

Other Forms of Salidroside:

Salidroside 相关抗体

Top Publications Citing Use of Products

    Salidroside purchased from MCE. Usage Cited in: Int J Oncol. 2019 Jun;54(6):1969-1980.  [Abstract]

    Apoptosis‑related protein expression in MG63 cells in response to various concentrations of Salidroside is detected via western blot analysis.

    查看 mTOR 亚型特异性产品:

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    mTOR mTORC1 mTORC2

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

    IC50 & Target[2]

    mTOR

     

    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    HeLa IC50
    10.493 μM
    Compound: Sal
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    		[PMID: 34978808]
    MDA-MB-231 IC50
    40 μM
    Compound: 2
    Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
    Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
    		[PMID: 33650861]
    PC-12 EC50
    0.3 μM
    Compound: Cpd i
    Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay
    Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay
    		[PMID: 33097301]
    体外研究
    (In Vitro)

    Salidroside (100 μM) 抑制脯氨酰内肽酶 (PEP) 活性 (10.6±1.9%)。脯氨酰内肽酶是一种在含脯氨酸神经肽酶的代谢中发挥作用的酶，该酶被认为与学习和记忆有关[1]。
    Salidroside 是在红景天中发现的主要苯丙素苷之一。在许多国家，Salidroside 几乎每天都作为营养补充剂食用，并已被确定具有潜在的抗疲劳和缺氧、抗衰老和抗阿尔茨海默病活性。Salidroside 可通过增加 mTOR、p-mTOR 和 MyHC 表达来改善肌肉营养[2]。
    SH-SY5Y 细胞暴露于 0-600μM MPP+ 12-48 小时，结果表明 MPP+ 导致细胞活力以浓度和时间依赖性方式显着降低。将细胞用 25-100 μM Salidroside (Sal) 预处理 24 小时，然后再暴露于 500 μM MPP+ 24 小时。Salidroside 浓度依赖性地防止 MPP+ 诱导的细胞活力下降。膜联蛋白 V/PI 染色是检测凋亡细胞的常用方法。Salidroside 显着减少 MPP+ 处理的膜联蛋白 V/PI 染色细胞的数量，且呈浓度依赖性。凋亡细胞也可以通过 Hoechs t染色进行形态学评估。在 Hoechst 染色中，凋亡细胞的特征是核尺寸减小、染色质浓缩、荧光强烈和核碎裂。Salidroside 显着抑制 MPP+ 诱导的 SH-SY5Y 细胞中染色质浓缩、强荧光和核碎裂的增加[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Salidroside 相关抗体:
    体内研究
    (In Vivo)

    Salidroside 是从药用食品植物红景天中提取的天然抗氧化剂。Salidroside (100 mg/kg/day) 对 db/db 小鼠表现出强烈的降血糖作用，与 Metformin (200 mg/kg/day) 的作用相似[4]。
    Salidroside (10/20/40 mg/kg/day) 可诱导的小鼠睾丸损伤模型[6]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    300.30

    Formula

    C14H20O7
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    红景天苷；毛柳甙；红景天甙
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : 125 mg/mL (416.25 mM; 超声助溶)

    DMSO 中的溶解度 : 100 mg/mL (333.00 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.3300 mL 16.6500 mL 33.3000 mL
    5 mM 0.6660 mL 3.3300 mL 6.6600 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： PBS

      Solubility: 100 mg/mL (333.00 mM); 澄清溶液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.90%

    COA (283 KB) HNMR (288 KB) LCMS (87 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [3]

    SH-SY5Y cells are seeded in 96-well plates at 1×104 cells per well. After the treatment with Salidroside (25-100?μM) and MPP+, cell viability is measured by MTT assay. Briefly, cells are incubated with 500?μg/mL MTT at 37°C for 4?h. After that, the medium is removed and 150?μL DMSO is added and shaking is conducted for 10?min. Absorbance is measured at 570?nm in a microplate reader and the results are expressed as folds of control[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [4]

    Mice[4]
    The 4-week-old male C57BL/6 mice are fed a high-fat diet (HFD) (n=16) or normal chow diet (n=8). After 10 weeks of the HFD, salidroside intervention (100 mg/kg/day) is initiated by gavage once a day for 5 weeks. The control groups are given vehicle (saline). The 4-week-old male C57Bl/KsJ (BKS) mice (wild type, n=8) and BKS.Cg-Dock7m +/+ Leprdb/J (db/db) mice (n=16) are used. Salidroside (100 mg/kg/day) is administrated orally by gavage once a day for 5 weeks. The control groups are given vehicle (saline). Fasting blood glucose and body weight of mice are monitored every 5 days. Glucose measurements are performed on blood drawn from the tail vein using a Glucometer.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Salidroside 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 3.3300 mL 16.6500 mL 33.3000 mL 83.2501 mL
    5 mM 0.6660 mL 3.3300 mL 6.6600 mL 16.6500 mL
    10 mM 0.3330 mL 1.6650 mL 3.3300 mL 8.3250 mL
    15 mM 0.2220 mL 1.1100 mL 2.2200 mL 5.5500 mL
    20 mM 0.1665 mL 0.8325 mL 1.6650 mL 4.1625 mL
    25 mM 0.1332 mL 0.6660 mL 1.3320 mL 3.3300 mL
    30 mM 0.1110 mL 0.5550 mL 1.1100 mL 2.7750 mL
    40 mM 0.0833 mL 0.4163 mL 0.8325 mL 2.0813 mL
    50 mM 0.0666 mL 0.3330 mL 0.6660 mL 1.6650 mL
    60 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3875 mL
    80 mM 0.0416 mL 0.2081 mL 0.4163 mL 1.0406 mL
    100 mM 0.0333 mL 0.1665 mL 0.3330 mL 0.8325 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Salidroside10338-51-9Rhodioloside红景天苷毛柳甙红景天甙PINK1/ParkinmTORApoptosisProlyl Endopeptidase (PREP)Mammalian target of Rapamycinprolyl oligopeptidasePOPInhibitorinhibitorinhibit

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