Yuanhuadin

目录号: HY-127067: FAQs
Data Sheet 产品使用指南技术支持

Yuanhuadin 提取自芫花 Daphne genkwa，通过抑制 Akt/mTOR 和 EGFR 通路具有抗肿瘤活性，同时也可以诱导细胞周期停滞和流产。

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Yuanhuadin Chemical Structure

CAS No. : 76402-66-9

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•同靶点蛋白产品:

查看 EGFR 亚型特异性产品:

查看所有亚型

EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Akt Akt1 Akt2 Akt3

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生物活性
纯度 & 产品资料
参考文献

生物活性

Yuanhuadin, extracted from Genkwa Flos Daphne genkwa, has antitumor activity through inhibiting Akt/mTOR and EGFR pathways, induce cell-cycle arrest and abortion^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 50 μM Compound: 9	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 23558238]
A549	IC₅₀	12 nM Compound: 1	Antiproliferative activity against human A549 cells after 3 days by SRB assay Antiproliferative activity against human A549 cells after 3 days by SRB assay	[PMID: 21916433]
B16	IC₅₀	0.06 μM Compound: 4	Inhibition of melanin production in alpha-MSH stimulated mouse B16 cells after 72 hrs by spectrophotometry Inhibition of melanin production in alpha-MSH stimulated mouse B16 cells after 72 hrs by spectrophotometry	[PMID: 23623417]
B16	IC₅₀	22 μM Compound: 4	Cytotoxicity against alpha-MSH stimulated mouse B16 cells after 72 hrs by MTT assay Cytotoxicity against alpha-MSH stimulated mouse B16 cells after 72 hrs by MTT assay	[PMID: 23623417]
HCT-116	IC₅₀	10.2 μM Compound: 1	Antiproliferative activity against human HCT116 cells after 3 days by SRB assay Antiproliferative activity against human HCT116 cells after 3 days by SRB assay	[PMID: 21916433]
HCT-116	IC₅₀	32.65 μM Compound: 9	Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 23558238]
HeLa	IC₅₀	17.06 μM Compound: 9	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 23558238]
HepG2	IC₅₀	26.27 μM Compound: 9	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 23558238]
HL-60	IC₅₀	30.05 μM Compound: 9	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 23558238]
HT-1080	IC₅₀	< 0.1 μM Compound: 9	Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay	[PMID: 23558238]
K562	IC₅₀	22.16 μM Compound: 9	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 23558238]
LoVo	IC₅₀	> 10 μM Compound: 10	Cytotoxicity against human LoVo cells after 24 hrs by MTT assay Cytotoxicity against human LoVo cells after 24 hrs by MTT assay	[PMID: 32223193]
MCF7	IC₅₀	4.11 μM Compound: 9	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 23558238]
MT4	CC₅₀	> 6.8 μM Compound: 14	Cytotoxicity against human MT4 cells incubated for 3 days by CellTiter-Glo luminescent assay Cytotoxicity against human MT4 cells incubated for 3 days by CellTiter-Glo luminescent assay	[PMID: 31860304]
NCI-H1299	IC₅₀	5.6 μM Compound: 1	Antiproliferative activity against human H1299 cells after 3 days by SRB assay Antiproliferative activity against human H1299 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H1993	IC₅₀	4.1 nM Compound: 1	Antiproliferative activity against gefitinib resistant human NCI-H1993 cells after 3 days by SRB assay Antiproliferative activity against gefitinib resistant human NCI-H1993 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H1993	IC₅₀	4.7 nM Compound: 1	Antiproliferative activity against human NCI-H1993 cells after 3 days by SRB assay Antiproliferative activity against human NCI-H1993 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H292	IC₅₀	< 1 x 10^-6 μM Compound: 1	Antiproliferative activity against human NCI-H292 cells after 3 days by SRB assay Antiproliferative activity against human NCI-H292 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H292	IC₅₀	< 1 x 10^-6 μM Compound: 1	Antiproliferative activity against gefitinib resistant human NCI-H292 cells after 3 days by SRB assay Antiproliferative activity against gefitinib resistant human NCI-H292 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H358	IC₅₀	9.1 μM Compound: 1	Antiproliferative activity against human NCI-H358 cells after 3 days by SRB assay Antiproliferative activity against human NCI-H358 cells after 3 days by SRB assay	[PMID: 21916433]
PC-3	IC₅₀	7.4 μM Compound: 1	Antiproliferative activity against human PC3 cells after 3 days by SRB assay Antiproliferative activity against human PC3 cells after 3 days by SRB assay	[PMID: 21916433]
RKO	IC₅₀	> 10 μM Compound: 10	Cytotoxicity against human RKO cells after 24 hrs by MTT assay Cytotoxicity against human RKO cells after 24 hrs by MTT assay	[PMID: 32223193]
SK-HEP1	IC₅₀	12.9 μM Compound: 1	Antiproliferative activity against human SKHEP1 cells after 3 days by SRB assay Antiproliferative activity against human SKHEP1 cells after 3 days by SRB assay	[PMID: 21916433]
SK-MES-1	IC₅₀	< 1 x 10^-6 μM Compound: 1	Antiproliferative activity against human SK-MES cells after 3 days by SRB assay Antiproliferative activity against human SK-MES cells after 3 days by SRB assay	[PMID: 21916433]
SNU-638	IC₅₀	> 20 μM Compound: 1	Antiproliferative activity against human SNU638 cells after 3 days by SRB assay Antiproliferative activity against human SNU638 cells after 3 days by SRB assay	[PMID: 21916433]
SW480	IC₅₀	11.8 μM Compound: 1	Antiproliferative activity against human SW480 cells after 3 days by SRB assay Antiproliferative activity against human SW480 cells after 3 days by SRB assay	[PMID: 21916433]
SW-620	IC₅₀	> 10 μM Compound: 10	Cytotoxicity against human SW620 cells after 24 hrs by MTT assay Cytotoxicity against human SW620 cells after 24 hrs by MTT assay	[PMID: 32223193]
T47D	IC₅₀	12.7 μM Compound: 1	Antiproliferative activity against human T47D cells after 3 days by SRB assay Antiproliferative activity against human T47D cells after 3 days by SRB assay	[PMID: 21916433]
U-937	IC₅₀	14.66 μM Compound: 9	Cytotoxicity against human U937 cells after 48 hrs by MTT assay Cytotoxicity against human U937 cells after 48 hrs by MTT assay	[PMID: 23558238]

分子量

586.67

Formula

C₃₂H₄₂O₁₀

CAS 号

76402-66-9

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Christian Bailly, et al. Yuanhuacin and Related Anti-Inflammatory and Anticancer Daphnane Diterpenes from Genkwa Flos—An Overview. Biomolecules. 2022 Feb; 12(2): 192.

Yuanhuadin 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Yuanhuadin76402-66-9EGFRAktmTOREpidermal growth factor receptorErbB-1HER1PKBProtein kinase BMammalian target of RapamycinCancerInflammationAbortionInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Yuanhuadin

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生物活性

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参考文献

Yuanhuadin 相关分类

摩尔计算器

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The molarity calculator equation

The dilution calculator equation

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