2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K/mTOR Inhibitor-7

PI3K/mTOR Inhibitor-7 (Compound 19i) 是一种有效的 PI3K/mTOR 双重抑制剂。PI3K/mTOR Inhibitor-7 的效力比阳性对照 gedatolisib 高 4.7 倍（0.3 对 1.4 μM，IC50 值）。PI3K/mTOR Inhibitor-7 在 10 μM 时显着抑制 PI3K/Akt/mTOR 信号通路。PI3K/mTOR Inhibitor-7 具有研究癌症疾病的潜力。

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PI3K/mTOR Inhibitor-7 Chemical Structure

PI3K/mTOR Inhibitor-7 Chemical Structure

CAS No. : 2456295-65-9

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PI3K/mTOR Inhibitor-7 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K/mTOR Inhibitor-7 (Compound 19i) is a potent and dual inhibitor of PI3K/mTOR. PI3K/mTOR Inhibitor-7 shows 4.7-fold higher potency than the positive control gedatolisib (0.3 vs. 1.4 μM, IC50 values). PI3K/mTOR Inhibitor-7 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-7 has the potential for the research of cancer diseases[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CNE-2 IC50
6.9 μM
Compound: 19i
Antiproliferative activity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
HCT-116 IC50
0.3 μM
Compound: 19i
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
HeLa IC50
2.4 μM
Compound: 19i
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
HepG2 IC50
1.3 μM
Compound: 19i
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
MCF7 IC50
1.2 μM
Compound: 19i
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
MDA-MB-231 IC50
4.8 μM
Compound: 19i
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
分子量

571.63

Formula

C29H33N9O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K/mTOR Inhibitor-7 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/mTOR Inhibitor-72456295-65-9PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycingedatolisibcancerInhibitorinhibitorinhibit

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