2. Autophagy Apoptosis PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK
  3. Autophagy Apoptosis PI3K Akt mTOR FAK
  4. Stellettin B

Stellettin B 是一种可以从海洋海绵 Jaspis stellifera 中分离得到的三萜化合物。Stellettin B 可以通过阻断 PI3K/Akt/mTOR 通路诱导人非小细胞肺癌 A549 细胞 G1 期阻滞、凋亡 (apoptosis) 和自噬 (autophagy)。Stellettin B 可以通过减少 MAPK 和 FAK/PI3K/AKT/mTOR 信号通路的激活来减少肝癌细胞的迁移和侵袭。Stellettin B 可用于多种肿瘤的研究。

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Stellettin B Chemical Structure

Stellettin B Chemical Structure

CAS No. : 184885-91-4

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Stellettin B 相关抗体

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Stellettin B is a triterpenoid compound that can be isolated from the marine sponge Jaspis stellifera. Stellettin B induces G1 phase arrest, apoptosis, and autophagy in human non-small cell lung cancer A549 cells by blocking the PI3K/Akt/mTOR pathway. Stellettin B can reduce the migration and invasion of liver cancer cells by decreasing the activation of the MAPK and FAK/PI3K/AKT/mTOR signaling pathways. Stellettin B can be used in the study of various tumors[1][2].
分子量

462.62

Formula

C30H38O4
CAS 号
结构分类
初始来源

Jaspis stellifera
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Stellettin B 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Stellettin B184885-91-4AutophagyApoptosisPI3KAktmTORFAKPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseapoptosisautophagyFAK/PI3K/AKT/mTORtumorInhibitorinhibitorinhibit

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