2. PI3K/Akt/mTOR
  3. mTOR Akt
  4. Royleanone

Royleanone 是一种从植物中分离出来的二萜类化合物，通过诱导细胞周期停滞和线粒体介导的细胞凋亡来抑制癌细胞的增殖，还抑制细胞迁移潜能，抑制 LNCaP 前列腺癌细胞中的 mTOR/PI3/AKT 信号通路。

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Royleanone Chemical Structure

Royleanone Chemical Structure

CAS No. : 6812-87-9

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Royleanone 相关抗体

Top Publications Citing Use of Products

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mTOR mTORC1 mTORC2

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1].

IC50 & Target

mTOR/PI3/AKT[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
30.14 μM
Compound: 20
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
BXPC-3 GI50
51.04 μM
Compound: 20
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
HL-60 IC50
> 30 μM
Compound: 3
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 23865778]
HL-60 GI50
36.33 μM
Compound: 20
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
MCF7 IC50
> 30 μM
Compound: 3
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 23865778]
MIA PaCa-2 IC50
32.5 μM
Compound: 3
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
[PMID: 21775156]
MOLT-3 IC50
13.6 μM
Compound: 3
Cytotoxicity against human MOLT3 cells after 72 hrs by MTT assay
Cytotoxicity against human MOLT3 cells after 72 hrs by MTT assay
[PMID: 23865778]
MRC5 GI50
45.7 μM
Compound: 20
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
PANC-1 GI50
52.55 μM
Compound: 20
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
PC-3 GI50
27.07 μM
Compound: 20
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
SK-MEL-1 IC50
> 30 μM
Compound: 3
Cytotoxicity against human SK-MEL-1 cells after 72 hrs by MTT assay
Cytotoxicity against human SK-MEL-1 cells after 72 hrs by MTT assay
[PMID: 23865778]
U-937 IC50
> 30 μM
Compound: 3
Cytotoxicity against human U937 cells after 72 hrs by MTT assay
Cytotoxicity against human U937 cells after 72 hrs by MTT assay
[PMID: 23865778]
体外研究
(In Vitro)

Royleanone (0-200 μM; 48 h) 以剂量依赖性方式抑制 LNCaP 癌细胞的活力，IC50 为 12.5 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Royleanone 相关抗体:
分子量

316.43

Formula

C20H28O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Royleanone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Royleanone6812-87-9NSC 122417NSC122417NSC-122417mTORAktMammalian target of RapamycinPKBProtein kinase BmTOR/PI3/AKTInhibitorinhibitorinhibit

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