2. Protein Tyrosine Kinase/RTK Apoptosis PI3K/Akt/mTOR Stem Cell/Wnt JAK/STAT Signaling Epigenetics MAPK/ERK Pathway GPCR/G Protein
  3. Src Apoptosis IAP Survivin Akt mTOR JAK STAT Ras p38 MAPK
  4. K882

K882 (Compound 4e) 是一种 Src 抑制剂，KD 为 0.315 μM。K882 诱导凋亡(Apoptosis)。K882 抑制 XIAP 和 Survivin。K882 抑制 PI3K/Akt/mTOR、Jak1/Stat3、Ras/MAPK 信号通路的激活。K882 对非小细胞肺癌 具有抗肿瘤活性。

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K882 Chemical Structure

K882 Chemical Structure

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K882 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

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Lck Fyn Blk

查看 IAP 亚型特异性产品:

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cIAP cIAP-1 cIAP-2 XIAP

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 mTOR 亚型特异性产品:

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mTOR mTORC1 mTORC2

查看 JAK 亚型特异性产品:

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JAK1 JAK2 JAK3 Tyk2 JAK

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

查看 Ras 亚型特异性产品:

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K-Ras H-Ras N-Ras Ras

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

K882 (Compound 4e) is a Src inhibitor, with KD of 0.315 μM. K882 induces Apoptosis. K882 inhibits XIAP and Survivin. K882 inhibits the activation of PI3K/Akt/mTOR, Jak1/Stat3, Ras/MAPK signaling pathways. K882 shows anti-tumor activity against non-small cell lung cancer[1].

IC50 & Target[1]

PI3Kα

 

XIAP

 

JAK1

 

Stat-3

 

体外研究
(In Vitro)

K882 (0.5-8 μM，24-72 h) 对 KRASG12C 突变 NCI-H358 细胞的增殖、迁移和侵袭表现出显著的抑制活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

K882 相关抗体:

Cell Cycle Analysis[1]

Cell Line: NCI-H358
Concentration: 0.5, 1, 2 and 4 μM
Incubation Time: 24 h
Result: Blocked the NCI-H358 cell cycle in the G2/M phase.

Cell Cycle Analysis[1]

Cell Line: NCI-H358
Concentration: 1, 2, 4, 8 μM
Incubation Time: 24 h
Result: Increased the rate of apoptotic cells concentration-dependently.
Inhibited the expressions of two apoptosis inhibitory proteins (XIAP and Survivin).
体内研究
(In Vivo)

K882 (25-100 mg/kg，腹腔注射，每天一次，31天) 抑制 NCI-H358 异种移植肿瘤小鼠模型中KRASG12C 突变型 NSCLC 异种移植瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCI-H358 xenograft tumor mice model[1]
Dosage: 25, 50 and 100 mg/kg,
Administration: Intraperitoneal injection (i.p.), once a day, 31 days
Result: Decreased tumor volume.
Showed the tumor inhibitory rates of 42.48 % (25 mg/kg), 49.72% (50 mg/kg) and 60.39 % (100 mg/kg).
Abrogated the phosphorylation at Y416 of Src.
Did not exhibit any apparent damage in the vital organs.
分子量

292.33

Formula

C18H16N2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

K882 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K882K 882K-882SrcApoptosisIAPSurvivinAktmTORJAKSTATRasp38 MAPKPKBProtein kinase BMammalian target of RapamycinJanus kinaseNCI-H358anti-tumorNSCLCcell cycle arrestmigrationinvasionxenograftMice.Inhibitorinhibitorinhibit

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