2. PI3K/Akt/mTOR
  3. mTOR
  4. mTOR inhibitor-2

mTOR inhibitor-2 是有效，选择性，可口服的 mTOR 抑制剂，IC50为7 nM。mTOR Inhibitor 1抑制mTORC1 (pS6 and p4E-BP1) 和mTORC2 (pAKT (S473)) 底物的细胞磷酸化。

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mTOR inhibitor-2 Chemical Structure

mTOR inhibitor-2 Chemical Structure

CAS No. : 2219323-96-1

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mTOR inhibitor-2 相关抗体

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查看 mTOR 亚型特异性产品:

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

mTOR inhibitor-2 is a highlt potent, selective and oral mTOR inhibitor with an IC50 of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates[1].

IC50 & Target

mTOR

7 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
441 nM
Compound: 9m
Growth inhibition of human HeLa cells after 72 hrs by CCK8 assay
Growth inhibition of human HeLa cells after 72 hrs by CCK8 assay
[PMID: 29308895]
MCF7 IC50
103 nM
Compound: 9m
Growth inhibition of human MCF7 cells after 72 hrs by CCK8 assay
Growth inhibition of human MCF7 cells after 72 hrs by CCK8 assay
[PMID: 29308895]
MDA-MB-231 IC50
100 nM
Compound: 9m
Growth inhibition of human MDA-MB-231 cells after 72 hrs by CCK8 assay
Growth inhibition of human MDA-MB-231 cells after 72 hrs by CCK8 assay
[PMID: 29308895]
NCI-H460 IC50
1775 nM
Compound: 9m
Growth inhibition of human H460 cells after 72 hrs by CCK8 assay
Growth inhibition of human H460 cells after 72 hrs by CCK8 assay
[PMID: 29308895]
OVCAR-5 IC50
2831 nM
Compound: 9m
Growth inhibition of human OVCAR5 cells after 72 hrs by CCK8 assay
Growth inhibition of human OVCAR5 cells after 72 hrs by CCK8 assay
[PMID: 29308895]
SiHa IC50
110 nM
Compound: 9m
Growth inhibition of human SiHa cells after 72 hrs by CCK8 assay
Growth inhibition of human SiHa cells after 72 hrs by CCK8 assay
[PMID: 29308895]
SK-OV-3 IC50
1850 nM
Compound: 9m
Growth inhibition of human SKOV3 cells after 72 hrs by CCK8 assay
Growth inhibition of human SKOV3 cells after 72 hrs by CCK8 assay
[PMID: 29308895]
T47D IC50
205 nM
Compound: 9m
Growth inhibition of human T47D cells after 72 hrs by CCK8 assay
Growth inhibition of human T47D cells after 72 hrs by CCK8 assay
[PMID: 29308895]
分子量

411.46

Formula

C23H21N7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

mTOR inhibitor-2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mTOR inhibitor-22219323-96-1mTOR inhibitor2mTOR inhibitor 2mTORMammalian target of RapamycinInhibitorinhibitorinhibit

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