2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. NVP-BBD130

NVP-BBD130 是一种有效的、稳定的、ATP 竞争性的、具有口服活性的 PI3K 和 mTOR 抑制剂。

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NVP-BBD130 Chemical Structure

NVP-BBD130 Chemical Structure

CAS No. : 853910-61-9

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NVP-BBD130 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 mTOR 亚型特异性产品:

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NVP-BBD130 is a potent, stable, ATP-competitive and orally active dual PI3K and mTOR inhibitor[1]. NVP-BBD130 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PI3K, mTOR[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
U-87MG ATCC IC50
33 nM
Compound: 7
Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISA
Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISA
[PMID: 18248814]
体外研究
(In Vitro)

NVP-BBD130 (1 μM; 72 h) blocks proliferation of melanoma cells, arrests cell cycle at G1 phase in A2058 cells but not C32 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NVP-BBD130 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Melanoma cells
Concentration: 1 μM
Incubation Time: 3 days
Result: Showed a long-term effect on melanoma cell proliferation.

Western Blot Analysis[1]

Cell Line: A2058 and C32 cells
Concentration: 1 μM
Incubation Time: 0, 0.5, 1, 2, 4, 8, 12, 24, 48 and 72 h
Result: Decreased phosphorylation of PKB/Akt, whereas the phosphorylation status of MAPK was not affected.
Down-regulated the expression of cyclin D1, induced p27Kip1 expression in A2058 cells.

Cell Cycle Analysis[1]

Cell Line: A2058 cells
Concentration: 1 μM
Incubation Time: 3 days
Result: Resulted in a complete arrest of most tumor cells in G1.
体内研究
(In Vivo)

NVP-BBD130 (40 mg/kg; p.o.; daily for 2 weeks) efficiently attenuates tumor growth at primary and lymph node metastatic sites with no obvious toxicity, and is well tolerant in B16BL6 mouse melanoma model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL6 mice, syngeneic B16BL6 mouse melanoma model[1]
Dosage: 40 mg/kg
Administration: Oral administration, daily for 2 weeks
Result: Reduced primary tumor size, showed a significant reduction in the size of the cervical lymph node metastasis.
分子量

443.50

Formula

C28H21N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NVP-BBD130 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NVP-BBD130853910-61-9PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycinATP-competitiveorally activeanticancermelanoma cellsA2058Inhibitorinhibitorinhibit

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目录号：
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