2. PI3K/Akt/mTOR
  3. Akt mTOR
  4. 22-(4′-py)-JA

22-(4′-py)-JA  (Synonyms: 22-(4′-Pyridinecarbonyl) jorunnamycin A)

目录号: HY-155721
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摩尔计算器

22-(4′-py)-JA 是久那霉素 A (JA) 的半合成衍生物，能够从泰国蓝海绵 (Xestospongia sp.) 中分离得到。22-(4′-py)-JA 具有抗转移活性，能够抑制 AKT/mTOR/p70S6K 信号传导。22-(4′-py)-JA 抑制人脐静脉内皮细胞 (HUVEC) 中的肿瘤细胞侵袭和管形成，下调金属蛋白酶（MMP-2 和 MMP-9）、缺氧诱导因子 1α (HIF-1α) 和血管内皮生长因子 (VEGF)。22-(4′-py)-JA 对非小细胞肺癌 (NSCLC) 具有有效抗癌活性。

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22-(4′-py)-JA Chemical Structure

22-(4′-py)-JA Chemical Structure

CAS No. : 1178895-15-2

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22-(4′-py)-JA 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

22-(4′-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4′-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4′-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF). 22-(4′-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC)[1].

体内研究
(In Vivo)

22-(4′-py)-JA

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

598.60

Formula

C32H30N4O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

22-(4′-py)-JA 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

22-(4′-py)-JA1178895-15-222-(4′-Pyridinecarbonyl) jorunnamycin AAktmTORPKBProtein kinase BMammalian target of Rapamycinnon-small cell lung cancerantimetastaticjunamycin A derivativeInhibitorinhibitorinhibit

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