2. Cell Cycle/DNA Damage Epigenetics PI3K/Akt/mTOR
  3. HDAC PI3K mTOR
  4. HDAC-IN-43

HDAC-IN-43是一种强效的HDAC 1/3/6 抑制剂，IC50 值分别为82、45和24 nM。HDAC-IN-43是一种弱的PI3K/mTOR抑制剂，IC50 值分别为3.6 和 3.7 μM。HDAC-IN-43具有广谱的抗增殖活性。

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HDAC-IN-43 Chemical Structure

HDAC-IN-43 Chemical Structure

CAS No. : 1809163-24-3

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HDAC-IN-43 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

  • 生物活性

  • 参考文献

生物活性

HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity [1].

IC50 & Target

HDAC1

82 nM (IC50)

HDAC2

358 nM (IC50)

HDAC3

45 nM (IC50)

HDAC6

24 nM (IC50)

HDAC8

1441 nM (IC50)

HDAC10

182 nM (IC50)

HDAC11

9061 nM (IC50)

体外研究
(In Vitro)

HDAC-IN-43 demonstrats broad anti-cancer activities against 38 cancer cell lines at 72 hours [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-43 相关抗体:

Cell Viability Assay

Cell Line: K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2[1]
Concentration: 0.22-1.42 μM
Incubation Time: 72 h
Result: showed anti-cancer activities, the IC50 values of K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2 are 0.22-1.42 μM[1].
分子量

440.50

Formula

C22H28N6O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

HDAC-IN-43 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-431809163-24-3HDACPI3KmTORHistone deacetylasesPhosphoinositide 3-kinaseMammalian target of RapamycinInhibitorinhibitorinhibit

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产品名称：
HDAC-IN-43
目录号：
HY-147966
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