2. PI3K/Akt/mTOR Autophagy
  3. PI3K mTOR Autophagy
  4. Dactolisib hydrochloride

Dactolisib hydrochloride  (Synonyms: BEZ235 hydrochloride; NVP-BEZ235 hydrochloride)

目录号: HY-50673A
产品使用指南

摩尔计算器

Dactolisib (BEZ235) hydrochloride 是一种具有口服活性的、双重的 pan-class I PI3K 和 mTOR 抑制剂，作用于 p110α/γ/δ/β 和 mTOR，IC50 分别为 4 nM/5 nM/7 nM/75 nM 和 20.7 nM。Dactolisib hydrochloride (BEZ235) 抑制 mTORC1 和 mTORC2。

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Dactolisib hydrochloride Chemical Structure

Dactolisib hydrochloride Chemical Structure

CAS No. : 2319647-83-9

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Dactolisib hydrochloride 的其他形式现货产品:

Other Forms of Dactolisib hydrochloride:

Dactolisib hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 55 篇科研文献

WB

    Dactolisib hydrochloride purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2018 Aug 9;37(1):188.  [Abstract]

    Representative images of the western blotting analysis of TSSC3, ATG5, P62, LC3, Src, Akt, mTOR and their phosphorylated versions in MTF and SaOS2 cells. Cells are treated with TSSC3-overexpression, IGF-1, p-YEEI, and BEZ235 separately or in combination.

    Dactolisib hydrochloride purchased from MCE. Usage Cited in: Biomed Res Int. 2018 Aug 5;2018:8372085.  [Abstract]

    Changes of p-AKT and p-p70 S6K proteins after treatment with NVP-BEZ235 in Ishikawa and Ishikawa-TAX cells. Changes of p-AKT and p-p70 S6K proteins after treatment of Ishikawa and Ishikawa-TAX cells with NVP-BEZ235.

    Dactolisib hydrochloride purchased from MCE. Usage Cited in: Nat Commun. 2017 Jun 8;8:15617.  [Abstract]

    Immunoblot analysis of KRAS protein levels in parental (P) and resistant derivatives (R1 and R2) following 4 h treatment with the corresponding inhibitors Rapamycin, AZD2014, MLN0128, BEZ235 and 4EGI-1. Images are cropped for clarity from the same exposure of the same membrane.

    Dactolisib hydrochloride purchased from MCE. Usage Cited in: Oncotarget. 2017 Jul 11;8(28):45470-45483.  [Abstract]

    Activity of PI3K/AKT/mTOR is monitored by examining phosphorylation of AKT-S473, AKT-T308, and S6 by western blotting.

    Dactolisib hydrochloride purchased from MCE. Usage Cited in: Leukemia. 2014 Sep;28(9):1819-27.  [Abstract]

    Western blot analysis of human T-ALL cell lines treated for 24 hours using DMSO (vehicle control), 1 μM JQ1, 500 nM BEZ235, or both drugs in combination, using the indicated antibodies. Western blot analysis of these T-ALL cell lines following treatment with JQ1, BEZ235 or both drugs in combination reveals cooperative upregulation of BIM protein expression coupled to induction of apoptosis, as assessed by PARP cleavage.

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    mTOR mTORC1 mTORC2

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Dactolisib (BEZ235) hydrochloride is an orally active, dual pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR with IC50 of 4 nM/5 nM/7 nM/75 nM and 20.7 nM, respectively. Dactolisib hydrochloride (BEZ235) inhibits mTORC1 and mTORC2[1].

    分子量

    506.00

    Formula

    C30H24ClN5O
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Dactolisib hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dactolisib2319647-83-9BEZ235NVP-BEZ235BEZ 235BEZ-235PI3KmTORAutophagyPhosphoinositide 3-kinaseMammalian target of RapamycinInhibitorinhibitorinhibit

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