2. PI3K/Akt/mTOR Apoptosis Cell Cycle/DNA Damage
  3. Akt mTOR Caspase CDK
  4. Akt/mTOR-IN-1

Akt/mTOR-IN-1 (Compound 8r) 是 AKT/mTOR 信号通路抑制剂，IC50 值为 0.8 µM，具有抗癌活性。Akt/mTOR-IN-1 可以降低 Caspase 3 的表达，并提高自噬蛋白 Cyclin B1 的表达，诱导细胞自噬和凋亡。Akt/mTOR-IN-1 可用于非小细胞肺癌 (NSCLC) 领域研究。

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Akt/mTOR-IN-1 Chemical Structure

Akt/mTOR-IN-1 Chemical Structure

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Akt/mTOR-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 mTOR 亚型特异性产品:

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mTOR mTORC1 mTORC2

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Akt/mTOR-IN-1 (Compound 8r) is an AKT/mTOR signaling pathway inhibitor exhibiting an IC50 value of 0.8 µM with anticancer activity. Akt/mTOR-IN-1 can decrease the expression of Caspase 3 and increase the expression of the autophagic protein Cyclin B1, thereby inducing cell autophagy and apoptosis. Akt/mTOR-IN-1 can be used in research related to non-small cell lung cancer (NSCLC)[1].

IC50 & Target

Caspase 3

 

体外研究
(In Vitro)

Akt/mTOR-IN-1 (10 μM, 72 小时) 在 HepG2、MCF-7 和 MDA-MB-231 细胞中表现出有效的抑制活性[1]。
Akt/mTOR-IN-1 (2 μM, 12 小时) 在非小细胞肺癌（NSCLC）A549 细胞中通过 AKT/mTOR 信号通路诱导自噬性细胞死亡和凋亡[1]。
Akt/mTOR-IN-1 (0.3125-10 μM, 24 小时) 在非小细胞肺癌（NSCLC）A549 细胞中诱导 G2/M 期细胞周期阻滞和凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Akt/mTOR-IN-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7 cells, MDA-MB-231 cells, HepG2 cells
Concentration: 10 μM
Incubation Time: 72 h
Result: Inhibited the proliferation of cancer cell lines. The IC50 values for HepG2, MCF-7, and MDA-MB-231 cells were 1.3, 0.5, and 0.8, respectively.

Cell Cycle Analysis[1]

Cell Line: Non-small cell lung cancer (NSCLC) A549 cells
Concentration: 0.3125, 0.625, 1.25, 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Led to G2/M cell cycle arrest.

Western Blot Analysis[1]

Cell Line: Non-small cell lung cancer (NSCLC) A549 cells
Concentration: 0.5, 1, 5, 10 μM
Incubation Time: 12 h
Result: Could increase LC3B-II protein level and decrease Lamp1 protein level in a dose-dependent manner.
分子量

526.51

Formula

C31H21F3N2O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Akt/mTOR-IN-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Akt/mTOR-IN-1AktmTORCaspaseCDKPKBProtein kinase BMammalian target of RapamycinCyclin dependent kinaseMCF-7 cellsMDA-MB-231 cellsHepG2 cellsNon-small cell lung cancer (NSCLC) A549 cells Anticancer activityCancerInhibitorinhibitorinhibit

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