2. PI3K/Akt/mTOR Apoptosis
  3. Akt mTOR Caspase
  4. C-Reactive Protein (CRP) (174-185)

C-Reactive Protein (CRP) (174-185) 

目录号: HY-P1823 纯度: 99.83%
COA 产品使用指南

摩尔计算器

C-Reactive Protein (CRP) 是一种抗肺炎球菌血浆蛋白，可作为炎症标志物。C-Reactive Protein 可以通过激活补体保护小鼠免受肺炎球菌感染。C-Reactive Protein 可以通过 CD64/AKT/mTOR 通路抑制 caspase-3/9 的激活从而促进舌鳞状细胞癌小鼠的化疗耐药性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

C-Reactive Protein (CRP) (174-185) Chemical Structure

C-Reactive Protein (CRP) (174-185) Chemical Structure

CAS No. : 147516-85-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥750
In-stock
5 mg ￥1850
In-stock
10 mg ￥2950
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

C-Reactive Protein (CRP) (174-185) 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

C-Reactive Protein (CRP) is an anti-pneumococcal plasma protein that can serve as an inflammatory marker. C-Reactive protein can protect mice from pneumococcal infection by activating complement. C-Reactive protein can inhibit the activation of caspase-3/9 through the CD64/AKT/mTOR pathway, thereby promoting chemotherapy resistance in mice with tongue squamous cell carcinoma[1][5].
体外研究
(In Vitro)

C-Reactive Protein (CRP) (0-25 μg/mL; 24 h) 通过刺激 3T3-L1 脂肪细胞产生 CXCL7 来促进单核细胞迁移[3]。
C-Reactive Protein (CRP) 可以损害 G1/S 依赖性肾小管上皮细胞再生[4]。
C-Reactive Protein (CRP) (10 μg/mL, 4 天) 可以提高 TSCC 细胞活力并增加细胞对 DDP 的耐药性[5]。
C-Reactive Protein (CRP) 是一种在结构上高度保守的人类主要急性期血浆蛋白[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C-Reactive Protein (CRP) (174-185) 相关抗体:

Cell Migration Assay [3].

Cell Line: 3T3-L1 adipocytes
Concentration: 0-25 μg/mL
Incubation Time: 24 h
Result: Promoted cell migration.

Cell Viability Assay[5].

Cell Line: The human TSCC cell lines CAL27 and SCC4
Concentration: 10 μg/mL
Incubation Time: 4 days
Result: Improved TSCC cell viability.
体内研究
(In Vivo)

C-Reactive Protein (CRP) (25 μg; 每天 1 次; 7 天; 静脉注射) 可以通过激活补体保护小鼠免受肺炎球菌感染[1]。
C-Reactive Protein (CRP) (20 mg/kg; 每天 1 次; 3 天; 腹腔注射) 可以诱导大鼠巨噬细胞中的超氧阴离子释放和组织因子活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A murine model of pneumococcal infection[1].
Dosage: 25 μg
Administration: Intravenous injection (i.v.); once daily; 7 days
Result: Activated complement in mouse serum.
Animal Model: Male hooded Wistar rats (weighing 125-150 g)[2].
Dosage: 20 mg/kg
Administration: Intraperitoneal injection (i.p.); once daily; 3 days
Result: Upregulated PKC, NADPH oxidase, ERK, and JNK phosphorylation.
分子量

1276.48

Formula

C62H93N13O16
CAS 号
性状

固体

颜色

White to off-white

Sequence

Ile-Tyr-Leu-Gly-Gly-Pro-Phe-Ser-Pro-Asn-Val-Leu
Sequence Shortening

IYLGGPFSPNVL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

C-Reactive Protein (CRP) (174-185) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C-Reactive Protein (CRP) (174-185)147516-85-6AktmTORCaspasePKBProtein kinase BMammalian target of Rapamycincomplement activationpneumococcal bacteriachemotherapy resistanceInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
C-Reactive Protein (CRP) (174-185)
目录号：
HY-P1823
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z