1. PI3K/Akt/mTOR Epigenetics Vitamin D Related/Nuclear Receptor Apoptosis Autophagy
  2. Akt mTOR AMPK Androgen Receptor Apoptosis Autophagy
  3. Monascuspiloin

Monascuspiloin  (Synonyms: Monascinol)

目录号: HY-N12124
产品使用指南

Monascuspiloin (Monascinol) 具有抗雄激素活性,IC50 为 7 μM。Monascuspiloin 抑制 PC-3 和 LNCaP 增殖,IC50 分别为 45 和 47 μM。Monascuspiloin 通过抑制 Akt/mTOR 信号通路诱导 LNCaP 细胞凋亡 (apoptosis),通过激活 AMPK 信号通路诱导 PC-3 自噬 (autophagy),并在 G2/M 期阻滞细胞周期。Monascuspiloin 在小鼠体内表达抗肿瘤活性。

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Monascuspiloin Chemical Structure

Monascuspiloin Chemical Structure

CAS No. : 1011244-19-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC50 of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC50 of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice[1][2].

分子量

360.44

Formula

C21H28O5

CAS 号
结构分类
初始来源

Monascus pilosus BCRC 38093-FERMENTED RICE

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
HY-N12124
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