2. PI3K/Akt/mTOR
  3. Akt mTOR
  4. Dehydrovomifoliol

Dehydrovomifoliol 是 AKT/mTOR 的双重抑制剂。Dehydrovomifoliol 通过抑制 AKT/mTOR 信号通路来减少脂质积累和脂肪生成。Dehydrovomifoliol用于非酒精性脂肪性肝病 (NAFLD) 的研究。

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Dehydrovomifoliol Chemical Structure

Dehydrovomifoliol Chemical Structure

CAS No. : 39763-33-2

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规格 价格 是否有货 数量
1 mg ￥2100
1 - 2 周
5 mg ￥5250
1 - 2 周
10 mg   询价  
50 mg   询价  

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Customer Review

Other Forms of Dehydrovomifoliol:

Dehydrovomifoliol 相关抗体

Top Publications Citing Use of Products

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Akt Akt1 Akt2 Akt3

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dehydrovomifoliol is a AKT/mTOR dual inhibitor. Dehydrovomifoliol reduces lipid accumulation and lipogenesis by inhibiting the AKT/mTOR signaling pathway. Dehydrovomifoliol is used in nonalcoholic fatty liver disease research (NAFLD) .

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 64.4 μM
Compound: 12
Cytostatic activity against human A549 cells after 48 cells by MTT assay
Cytostatic activity against human A549 cells after 48 cells by MTT assay
[PMID: 21561060]
C8166 CC50
> 450.5 μM
Compound: 12
Cytotoxicity against human C8166 cells after 3 days by MTT assay
Cytotoxicity against human C8166 cells after 3 days by MTT assay
[PMID: 21561060]
C8166 EC50
> 450.5 μM
Compound: 12
Antiviral activity against Human immunodeficiency virus 1 3B infected in human C8166 cells assessed as numbers of syncytia after 3 days by MTT assay
Antiviral activity against Human immunodeficiency virus 1 3B infected in human C8166 cells assessed as numbers of syncytia after 3 days by MTT assay
[PMID: 21561060]
HL-60 IC50
> 64.4 μM
Compound: 12
Cytostatic activity against human HL60 cells after 48 cells by MTT assay
Cytostatic activity against human HL60 cells after 48 cells by MTT assay
[PMID: 21561060]
HT-29 IC50
> 10 μM
Compound: S7
Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
[PMID: 30057155]
HT-29 IC50
> 10 μM
Compound: S7
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30057155]
MCF7 IC50
> 64.4 μM
Compound: 12
Cytostatic activity against human MCF7 cells after 48 cells by MTT assay
Cytostatic activity against human MCF7 cells after 48 cells by MTT assay
[PMID: 21561060]
MDA-MB-435 IC50
> 10 μM
Compound: S7
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30057155]
OVCAR-3 IC50
> 10 μM
Compound: S7
Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30057155]
RAW264.7 IC50
> 50 μM
Compound: 10
Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
[PMID: 24963714]
RAW264.7 IC50
38.5 μM
Compound: 10
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
[PMID: 24963714]
SMMC-7721 IC50
> 64.4 μM
Compound: 12
Cytostatic activity against human SMMC7721 cells after 48 cells by MTT assay
Cytostatic activity against human SMMC7721 cells after 48 cells by MTT assay
[PMID: 21561060]
SW480 IC50
> 64.4 μM
Compound: 12
Cytostatic activity against human SW480 cells after 48 cells by MTT assay
Cytostatic activity against human SW480 cells after 48 cells by MTT assay
[PMID: 21561060]
分子量

222.28

Formula

C13H18O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dehydrovomifoliol 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dehydrovomifoliol39763-33-2AktmTORPKBProtein kinase BMammalian target of RapamycinNAFLDInhibitorinhibitorinhibit

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产品名称：
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目录号：
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