2. Immunology/Inflammation
  3. COX
  4. Withangulatin A

Withangulatin A 是一种选择性环氧合酶 2 (COX-2) 抑制剂。Withangulatin A 可从 Physalis angulata L 中分离得到。Withangulatin A 具有抗肿瘤、杀锥虫活性和抗炎作用。

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Withangulatin A Chemical Structure

Withangulatin A Chemical Structure

CAS No. : 120824-03-5

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规格 价格 是否有货 数量
1 mg ￥5504
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Customer Review

Withangulatin A 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Withangulatin A is a selective cyclooxygenase-2 (COX-2) inhibitor. Withangulatin A can be isolated from Physalis angulata L. Withangulatin A has anti-tumor, trypanocidal activity and anti-inflammatory function[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
2.37 μM
Compound: 1; WA
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
HepG2 IC50
2.85 μM
Compound: 1; WA
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
HK-2 IC50
6.41 μM
Compound: 1; WA
Cytotoxicity against human HK2 cells assessed as cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human HK2 cells assessed as cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
HT-29 IC50
2.48 μM
Compound: 1; WA
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
L02 IC50
8.21 μM
Compound: 1; WA
Cytotoxicity against human L02 cells assessed as cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
MCF7 IC50
6.32 μM
Compound: 1; WA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
分子量

526.62

Formula

C30H38O8
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 3 mg/mL (5.70 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8989 mL 9.4945 mL 18.9890 mL
5 mM 0.3798 mL 1.8989 mL 3.7978 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.76%

COA (302 KB) HNMR (211 KB) LCMS (118 KB)

产品使用指南 (1538 KB)
参考文献

Withangulatin A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8989 mL 9.4945 mL 18.9890 mL 47.4726 mL
5 mM 0.3798 mL 1.8989 mL 3.7978 mL 9.4945 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Withangulatin A120824-03-5COXCyclooxygenasecyclooxygenase-2 (COX-2)isolatePhysalis angulata Lanti-tumortrypanocidal activityanti-inflammatoryInhibitorinhibitorinhibit

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目录号：
HY-N10303
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