2. Gene
  3. TSHZ2 - teashirt zinc finger homeobox 2 Gene

TSHZ2 - teashirt zinc finger homeobox 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：teashirt 锌指同源盒 2

种属: Homo sapiens

同用名: TSH2; ZABC2; ZNF218; OVC10-2; C20orf17

基因 ID: 128553 | 基因类型: protein coding

关于 TSHZ2

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:52,972,358-53,495,330 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in gall bladder (RPKM 3.9), ovary (RPKM 3.7) and 23 other tissues.

功能概要

该基因是 teashirt C2H2 型锌指蛋白转录因子家族的成员。该基因编码的蛋白质具有五个 C2H2 型锌指、一个同源盒 DNA 结合结构域和一个卷曲螺旋结构域。预计该核蛋白将充当转录抑制因子。该基因被认为在乳腺癌和其他类型癌症的发生和发展中发挥作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 12 月]

This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of Cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

TSHZ2 基因产物(2)

mRNA Protein Name
NM_001193421.2 NP_001180350.1 teashirt homolog 2 isoform 2
NM_173485.6 NP_775756.3 teashirt homolog 2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24407287 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TSHZ2 蛋白结构

zf-C2H2_2

zf-C2H2_2: C2H2 type zinc-finger (2 copies) (266 - 301)

zf-C2H2_2

zf-C2H2_2: C2H2 type zinc-finger (2 copies) (380 - 407)

zf-C2H2_2

zf-C2H2_2: C2H2 type zinc-finger (2 copies) (928 - 1023)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1034 a.a.
蛋白主名 其他名称

teashirt homolog 2

cell growth-inhibiting protein 7

TSHZ2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TSHZ2 Q9NRE2 CCDC57 Homo sapiens Q2TAC2-2
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 CCDC57 Homo sapiens Q2TAC2-2
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra TSHZ2 Q9NRE2 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 CRACR2B Homo sapiens Q8N4Y2-3
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 CRACR2B Homo sapiens Q8N4Y2-3
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 MCC Homo sapiens P23508
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 MCC Homo sapiens P23508
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 CCDC88B Homo sapiens A6NC98
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 CCDC88B Homo sapiens A6NC98
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 SPTA1 Homo sapiens P02549
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 SPTA1 Homo sapiens P02549
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 GRIPAP1 Homo sapiens Q4V328
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 GRIPAP1 Homo sapiens Q4V328
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 COG3 Homo sapiens Q96JB2-2
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 COG3 Homo sapiens Q96JB2-2
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 PHAF1 Homo sapiens Q9BSU1
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 PHAF1 Homo sapiens Q9BSU1
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 CNTROB Homo sapiens Q8N137
Y2H Prey Pooling
32296183
Intra TSHZ2 Q9NRE2 CNTROB Homo sapiens Q8N137
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 GIGYF1 Homo sapiens O75420
Y2H Array
32296183
Intra TSHZ2 Q9NRE2 GIGYF1 Homo sapiens O75420
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Autosomal Recessive Alport Syndrome

Alport Syndrome, Recessive Type

Alport Syndrome, Autosomal Recessive

Alport Syndrome Autosomal Recessive

Alport Syndrome Recessive Type

Nephropathy And Deafness
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15149 TSHZ2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TSHZ2 VGNC VGNC:47904
Mus musculus TSHZ2 MGD MGI:2153084
Rattus norvegicus TSHZ2 RGD RGD:6490867
Macaca mulatta TSHZ2 VGNC VGNC:78875
Bos taurus TSHZ2 VGNC VGNC:59371
Felis catus TSHZ2 VGNC VGNC:66618
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