MCC - MCC regulator of WNT signaling pathway Gene

中文名称：WNT 信号通路的 MCC 调节因子

种属: Homo sapiens

同用名: MCC1

基因 ID: 4163 | 基因类型: protein coding

关于 MCC

Cytogenetic location: 5q22.2 Genomic coordinates (GRCh38): 5:113,022,106-113,488,453 (from NCBI)

This gene has 10 transcripts (splice variants), 160 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 18.3), skin (RPKM 6.6) and 21 other tissues.

功能概要

该基因是一种候选的结直肠肿瘤抑制基因，被认为可以负向调节细胞周期进程。小鼠中的同源基因表达与质膜和膜细胞器相关的磷蛋白，并且小鼠蛋白的过表达抑制进入 S 期。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MCC 基因产物(2)

mRNA	Protein	Name
NM_001085377.2	NP_001078846.2	colorectal mutant cancer protein isoform 1
NM_002387.3	NP_002378.2	colorectal mutant cancer protein isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14743216	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in establishment of protein localization	IDA IDA: 通过直接分析推断	18591935	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	18591935	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	24824780	GOA
involved in negative regulation of epithelial cell migration	IMP IMP: 通过突变表型推断	19555689	GOA
involved in negative regulation of epithelial cell proliferation	IDA IDA: 通过直接分析推断	18591935	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	18591935	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18591935	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	19555689	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MCC 蛋白结构

MCC-bdg_PDZ

0
200
400
600
829 a.a.

蛋白主名

其他名称

colorectal mutant cancer protein

MCC, WNT signaling pathway regulator

MCC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MCC	P23508	ZNF543	Homo sapiens	Q08ER8	Validated Y2H	32296183
Intra	MCC	P23508	ZNF792	Homo sapiens	Q3KQV3	Validated Y2H	32296183
Intra	MCC	P23508	CFAP58	Homo sapiens	Q5T655	Validated Y2H	32296183
Intra	MCC	P23508	SYT6	Homo sapiens	Q5T7P8-2	Validated Y2H	32296183
Intra	MCC	P23508	POLL	Homo sapiens	Q9UGP5-2	Validated Y2H	32296183
Intra	MCC	P23508	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	MCC	P23508	ZNF497	Homo sapiens	Q6ZNH5	Validated Y2H	32296183
Intra	MCC	P23508	TSHZ2	Homo sapiens	Q9NRE2	Validated Y2H	32296183
Intra	MCC	P23508	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	MCC	P23508	CEP57L1	Homo sapiens	Q8IYX8	Validated Y2H	32296183
Intra	MCC	P23508	UTP14C	Homo sapiens	Q5TAP6	Validated Y2H	32296183
Intra	MCC	P23508	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	MCC	P23508	ZNF438	Homo sapiens	Q7Z4V0	Validated Y2H	32296183
Intra	MCC	P23508	ZNF648	Homo sapiens	Q5T619	Validated Y2H	32296183
Intra	MCC	P23508	ESRRG	Homo sapiens	P62508-3	Validated Y2H	32296183
Intra	MCC	P23508	CCDC112	Homo sapiens	Q8NEF3-2	Validated Y2H	32296183
Intra	MCC	P23508	RASAL2	Homo sapiens	Q9UJF2-2	Validated Y2H	32296183
Intra	MCC	P23508	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	MCC	P23508	MGC50722	Homo sapiens	Q8IVT4	Validated Y2H	32296183
Intra	MCC	P23508	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	MCC	P23508	TRMT2A	Homo sapiens	Q8IZ69	Validated Y2H	32296183
Intra	MCC	P23508	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	MCC	P23508	LRRC45	Homo sapiens	Q96CN5	Validated Y2H	32296183
Intra	MCC	P23508	SLTM	Homo sapiens	Q9NWH9	Validated Y2H	32296183
Intra	MCC	P23508	GTF2E2	Homo sapiens	P29084	Y2H Array	21988832
Intra	MCC	P23508	GTF2E2	Homo sapiens	P29084	Anti Tag CoIP	21988832
Intra	MCC	P23508	NFKBIB	Homo sapiens	Q15653	Anti Tag CoIP	33961781
Intra	MCC	P23508	NFKBIB	Homo sapiens	Q15653	TAP	14743216
Intra	MCC	P23508	SCRIB	Homo sapiens	Q14160	Y2H	19555689
Intra	MCC	P23508	SCRIB	Homo sapiens	Q14160	Pull Down	19555689
Intra	MCC	P23508	SCRIB	Homo sapiens	Q14160	Anti Bait CoIP	19555689
Intra	MCC	P23508	TXLNA	Homo sapiens	P40222	Validated Y2H	32296183
Intra	MCC	P23508	CEP95	Homo sapiens	Q96GE4	Validated Y2H	32296183
Intra	MCC	P23508	CDKL3	Homo sapiens	Q8IVW4	Validated Y2H	32296183
Intra	MCC	P23508	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	MCC	P23508	NEK2	Homo sapiens	P51955	Anti Tag CoIP	33961781
Intra	MCC	P23508	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
Intra	MCC	P23508	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
Intra	MCC	P23508	C8orf33	Homo sapiens	Q9H7E9	Validated Y2H	32296183
Intra	MCC	P23508	NOL12	Homo sapiens	Q9UGY1	Validated Y2H	32296183
Intra	MCC	P23508	FAM161A	Homo sapiens	Q3B820	Validated Y2H	32296183
Intra	MCC	P23508	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	MCC	P23508	CCDC185	Homo sapiens	Q8N715	Validated Y2H	32296183
Intra	MCC	P23508	THAP7	Homo sapiens	Q9BT49	Validated Y2H	32296183
Intra	MCC	P23508	ELOA	Homo sapiens	Q14241	Validated Y2H	32296183
Intra	MCC	P23508	SYT17	Homo sapiens	Q9BSW7	Validated Y2H	32296183
Intra	MCC	P23508	IMP3	Homo sapiens	Q9NV31	Validated Y2H	32296183
Intra	MCC	P23508	CSNK1E	Homo sapiens	P49674	Anti Bait CoIP	17353931
Intra	MCC	P23508	CSNK1E	Homo sapiens	P49674	Y2H	21900206
Intra	MCC	P23508	CSNK1E	Homo sapiens	P49674	Anti Tag CoIP	33961781
Intra	MCC	P23508	C8orf48	Homo sapiens	Q96LL4	Validated Y2H	32296183
Intra	MCC	P23508	DNAAF4	Homo sapiens	Q8WXU2-2	Validated Y2H	32296183
Intra	MCC	P23508	MAGEE1	Homo sapiens	Q9HCI5	Anti Tag CoIP	33961781
Intra	MCC	P23508	MAGEE1	Homo sapiens	Q9HCI5	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Familial Adenomatous Polyposis

Adenomatous Polyposis Coli	Fap
Familial Polyposis Coli	Familial Multiple Polyposis Syndrome
Adenomatous Polyposis Of The Colon	Familial Intestinal Polyposis
Fpc	Familial Adenomatous Polyposis Of The Colon
Familial Multiple Polyposis	Familial Polyposis Of The Colon
Hereditary Polyposis Coli	Polyposis, Adenomatous Intestinal
Adenomatous Familial Polyposis	Adenomatous Familial Polyposis Syndrome
Myh-Associated Polyposis	Colorectal Adenomatous Polyposis
Adenomatous Polyposis, Familial	Mutyh-Associate Polyposis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-100298	Caldaret	Inhibitor	98.35%	Phase 2
HY-132251	MCC		≥95.0%	Phase 2
HY-119306	MCC-134	Modulator	/	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12815A	MCC950 sodium	Inhibitor	99.75%	否
HY-12815	MCC950	Inhibitor	99.62%	否
HY-D0975	Sulfo-SMCC sodium		98.30%	否
HY-101982	Lys-SMCC-DM1		99.61%	否
HY-132250	MCC-DM1		99.52%	否
HY-137245	Emlenoflast	Inhibitor	98.19%	否
HY-137245A	Emlenoflast sodium	Inhibitor	98.76%	否
HY-101982A	(Rac)-Lys-SMCC-DM1		98.18%	否
HY-100428	Netoglitazone	Agonist	99.88%	否
HY-119691	Alamifovir	Inhibitor	≥95.0%	否
HY-148528	SC-VC-PAB-N-Me-L-Ala-Maytansinol		98.16%	否
HY-128959	MCC-Modified Daunorubicinol		/	否
HY-101266A	Milademetan tosylate	MDM2 Inhibitor	/	否
HY-141143	MC(C5)-Val-Cit		/	否
HY-14936	Sofigatran	Inhibitor	/	否
HY-163982	FOXJ1 agonist 1	Activator	/	否
HY-RS08217	MCC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W800786	16:0 PE MCC		/	否
HY-W800787	18:1 PE MCC		/	否
HY-W190944	DM1-MCC-PEG3-Biotin		/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	MCC	VGNC	VGNC:68207
Canis familiaris	MCC	VGNC	VGNC:54780
Mus musculus	MCC	MGD	MGI:96930
Macaca mulatta	MCC	VGNC	VGNC:74675
Rattus norvegicus	MCC	RGD	RGD:1561988
Bos taurus	MCC	VGNC	VGNC:54784

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