2. Apoptosis
  3. MDM-2/p53
  4. Milademetan tosylate

Milademetan tosylate  (Synonyms: DS-3032 tosylate)

目录号: HY-101266A
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摩尔计算器

Milademetan tosylate 是 Milademetan (HY-101266) 的甲磺酸盐形式。Milademetan tosylate 是口服有效的 MDM2 抑制剂。Milademetan tosylate 在 G1 期阻滞细胞周期，诱导细胞凋亡 (apoptosis)。Milademetan tosylate 通过靶向 p53-MDM2 相互作用恢复 p53 活性，并对默克尔细胞癌 (MCC) 表现出抗癌活性。

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Milademetan tosylate Chemical Structure

Milademetan tosylate Chemical Structure

CAS No. : 1398569-75-9

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Milademetan tosylate 的其他形式现货产品:

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Milademetan tosylate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Milademetan tosylate is the tosylate salt form of Milademetan (HY-101266). Milademetan tosylate is an orally active inhibitor for MDM2. Milademetan tosylate arrests the cell cycle at G1 pahse, induces the apoptosis Milademetan tosylate restores the p53 activity by targeting the p53-MDM2 interaction, and exhibits anticancer activity against Merkel cell carcinoma (MCC)[1].

分子量

790.73

Formula

C37H42Cl2FN5O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Milademetan tosylate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Milademetan1398569-75-9DS-3032DS3032DS 3032MDM-2/p53Merkel cell carcinomaMCCorally activeMKL-1WaGaPeTaMS-1SA-1JARMCC-301MCC-336SW962NSG mouseInhibitorinhibitorinhibit

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