2. Gene
  3. CDKL3 - cyclin dependent kinase like 3 Gene

CDKL3 - cyclin dependent kinase like 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶样 3

种属: Homo sapiens

同用名: NKIAMRE

基因 ID: 51265 | 基因类型: protein coding

关于 CDKL3

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,283,345-134,371,624 (from NCBI)

This gene has 10 transcripts (splice variants), 116 orthologues and 26 paralogues. Biased expression in testis (RPKM 4.9), brain (RPKM 1.0) and 12 other tissues.

功能概要

该基因编码的蛋白质是细胞周期蛋白依赖性蛋白激酶 (CDK) 家族的成员。 CDK 家族成员与酿酒酵母 cdc28 和粟酒裂殖酵母 cdc2 的基因产物高度相似，并且已知是细胞周期进程的重要调节剂。该基因被鉴定为染色体 5q 缺失的白血病患者中缺失的基因。这种损失可能是骨髓细胞生成障碍的重要决定因素。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CDKL3 基因产物(7)

mRNA Protein Name
NM_001113575.2 NP_001107047.1 cyclin-dependent kinase-like 3 isoform 1
NM_001300853.2 NP_001287782.1 cyclin-dependent kinase-like 3 isoform 3
NM_001349363.2 NP_001336292.1 cyclin-dependent kinase-like 3 isoform 4
NM_001349364.2 NP_001336293.1 cyclin-dependent kinase-like 3 isoform 5
NM_001349365.2 NP_001336294.1 cyclin-dependent kinase-like 3 isoform 5
NM_001349366.2 NP_001336295.1 cyclin-dependent kinase-like 3 isoform 5
NM_016508.4 NP_057592.2 cyclin-dependent kinase-like 3 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDKL3 蛋白结构

Pkinase

Pkinase: Protein kinase domain (4 - 286)

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  • 592 a.a.
蛋白主名 其他名称

cyclin-dependent kinase-like 3

serine-threonine protein kinase NKIAMRE

CDKL3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CDKL3 Q8IVW4 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra CDKL3 Q8IVW4 ZBTB14 Homo sapiens O43829
Y2H Prey Pooling
25416956
Intra CDKL3 Q8IVW4 ZBTB14 Homo sapiens O43829
Y2H Array
25416956
Intra CDKL3 Q8IVW4 PIH1D2 Homo sapiens Q8WWB5
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
Intra CDKL3 Q8IVW4 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
32296183
Intra CDKL3 Q8IVW4 DNAAF6 Homo sapiens Q9NQM4
Y2H Prey Pooling
25416956
Intra CDKL3 Q8IVW4 DNAAF6 Homo sapiens Q9NQM4
Y2H Array
25416956
Intra CDKL3 Q8IVW4 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra CDKL3 Q8IVW4 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
Intra CDKL3 Q8IVW4 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
31515488
Intra CDKL3 Q8IVW4 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra CDKL3 Q8IVW4 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra CDKL3 Q8IVW4 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra CDKL3 Q8IVW4 LRP2BP Homo sapiens Q9P2M1
Validated Y2H
32296183
Intra CDKL3 Q8IVW4 LRP2BP Homo sapiens Q9P2M1
Y2H Array
32296183
Intra CDKL3 Q8IVW4 LRP2BP Homo sapiens Q9P2M1
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra CDKL3 Q8IVW4 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 ATG4A Homo sapiens Q8WYN0
Y2H Array
25416956
Intra CDKL3 Q8IVW4 MCC Homo sapiens P23508
Y2H Array
32296183
Intra CDKL3 Q8IVW4 MCC Homo sapiens P23508
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra CDKL3 Q8IVW4 STAMBP Homo sapiens O95630
Anti Tag CoIP
28514442
Intra CDKL3 Q8IVW4 STAMBP Homo sapiens O95630
Anti Tag CoIP
33961781
Intra CDKL3 Q8IVW4 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
Intra CDKL3 Q8IVW4 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra CDKL3 Q8IVW4 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra CDKL3 Q8IVW4 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra CDKL3 Q8IVW4 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra CDKL3 Q8IVW4 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra CDKL3 Q8IVW4 MDFI Homo sapiens Q99750
Y2H Array
25416956
Intra CDKL3 Q8IVW4 MDFI Homo sapiens Q99750
Validated Y2H
25416956
Intra CDKL3 Q8IVW4 FXR2 Homo sapiens P51116
Y2H Array
31515488
Intra CDKL3 Q8IVW4 FXR2 Homo sapiens P51116
Y2H Prey Pooling
25416956
Intra CDKL3 Q8IVW4 FXR2 Homo sapiens P51116
Validated Y2H
25416956
Intra CDKL3 Q8IVW4 FXR2 Homo sapiens P51116
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 FXR2 Homo sapiens P51116
Y2H Array
32296183
Intra CDKL3 Q8IVW4 ZBTB43 Homo sapiens O43298
Y2H Array
32296183
Intra CDKL3 Q8IVW4 ZBTB43 Homo sapiens O43298
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra CDKL3 Q8IVW4 TRIM37 Homo sapiens O94972
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 TRIM37 Homo sapiens O94972
Y2H Array
32296183
Intra CDKL3 Q8IVW4 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
32296183
Intra CDKL3 Q8IVW4 ZBTB8A Homo sapiens Q96BR9
Y2H Array
25416956
Intra CDKL3 Q8IVW4 ZBTB8A Homo sapiens Q96BR9
Y2H Array
32296183
Intra CDKL3 Q8IVW4 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
25416956
Intra CDKL3 Q8IVW4 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
32296183
Intra CDKL3 Q8IVW4 KASH5 Homo sapiens Q8N6L0
Y2H Array
25416956
Intra CDKL3 Q8IVW4 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra CDKL3 Q8IVW4 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra CDKL3 Q8IVW4 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Meckel Syndrome, Type 4

Meckel Syndrome 4

MKS4

Meckel-Gruber Syndrome, Type 4

Meckel Syndrome Type 4
Orofaciodigital Syndrome Vi

OFD6

Varadi-Papp Syndrome

Varadi Syndrome

Joubert Syndrome With Orofaciodigital Defect

Orofaciodigital Syndrome Type 6

Orofaciodigital Syndrome 6

Oral-Facial-Digital Syndrome, Type Vi

Ofds Vi

Polydactyly, Cleft Lip/Palate Or Lingual Lump, And Psychomotor Retardation

Polydactyly Cleft Lip Palate Psychomotor Retardation

Oral-Facial-Digital Syndrome Type 6

Polydactyly-Cleft Lip/Palate-Psychomotor Retardation Syndrome

Polydactyly - Cleft Lip/Palate - Psychomotor Retardation

Váradi Syndrome

Váradi-Papp Syndrome

Joubert Syndrome With Oral-Facial-Digital Syndrome

Oral-Facial-Digital Syndrome 6

Joubert-Orofaciodigital Syndrome

Orofaciodigital Syndrome, Type Vi
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-161847 HZ1 Inhibitor 99.20% 否
HY-RS02407 CDKL3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CDKL3 RGD RGD:619874
Macaca mulatta CDKL3 VGNC VGNC:70953
Bos taurus CDKL3 VGNC VGNC:27140
Felis catus CDKL3 VGNC VGNC:60710
Mus musculus CDKL3 MGD MGI:2388268
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