ZBTB43 - zinc finger and BTB domain containing 43 Gene

中文名称：含锌指和 BTB 域 43

种属: Homo sapiens

同用名: ZNF-X; ZBTB22B; ZNF297B

基因 ID: 23099 | 基因类型: protein coding

关于 ZBTB43

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:126,804,072-126,838,210 (from NCBI)

This gene has 5 transcripts (splice variants), 161 orthologues and 4 paralogues. Broad expression in bone marrow (RPKM 18.2), testis (RPKM 10.2) and 24 other tissues.

功能概要

启用序列特异性双链 DNA 结合活性。预计参与 RNA 聚合酶 II 的转录调控。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB43 基因产物(2)

mRNA	Protein	Name
NM_001135776.2	NP_001129248.1	zinc finger and BTB domain-containing protein 43
NM_014007.4	NP_054726.1	zinc finger and BTB domain-containing protein 43

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase III general transcription initiation factor binding	IPI IPI: 通过物理相互作用推断	16542149	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZBTB43 蛋白结构

BTB

zf-C2H2_4

zf-H2C2_2

0
100
200
300
400
467 a.a.

蛋白主名

其他名称

zinc finger and BTB domain-containing protein 43

zinc finger and BTB domain-containing protein 22B

ZBTB43 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ZBTB43	O43298	ZNF250	Homo sapiens	P15622-3	Validated Y2H	32296183
种属内	ZBTB43	O43298	DIP2A	Homo sapiens	Q14689-6	Y2H Prey Pooling	25416956
种属内	ZBTB43	O43298	SYT6	Homo sapiens	Q5T7P8-2	Y2H Prey Pooling	25416956
种属内	ZBTB43	O43298	SYT6	Homo sapiens	Q5T7P8-2	Validated Y2H	32296183
种属内	ZBTB43	O43298	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
种属内	ZBTB43	O43298	CIB3	Homo sapiens	Q96Q77	Validated Y2H	32296183
种属内	ZBTB43	O43298	CCDC13	Homo sapiens	Q8IYE1	Validated Y2H	32296183
种属内	ZBTB43	O43298	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
种属内	ZBTB43	O43298	LMO4	Homo sapiens	P61968	Y2H Prey Pooling	25416956
种属内	ZBTB43	O43298	DDX6	Homo sapiens	P26196	Validated Y2H	32296183
种属内	ZBTB43	O43298	PSMD3	Homo sapiens	O43242	Validated Y2H	25416956
种属内	ZBTB43	O43298	PSMD3	Homo sapiens	O43242	Y2H Array	25416956
种属内	ZBTB43	O43298	CDKL3	Homo sapiens	Q8IVW4	Validated Y2H	32296183
种属内	ZBTB43	O43298	MORF4L2	Homo sapiens	Q15014	Y2H Array	25416956
种属内	ZBTB43	O43298	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	25416956
种属内	ZBTB43	O43298	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
种属内	ZBTB43	O43298	AP1M1	Homo sapiens	Q9BXS5	Y2H Prey Pooling	25416956
种属内	ZBTB43	O43298	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
种属内	ZBTB43	O43298	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
种属内	ZBTB43	O43298	ARR3	Homo sapiens	P36575	Validated Y2H	25416956
种属内	ZBTB43	O43298	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
种属内	ZBTB43	O43298	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
种属内	ZBTB43	O43298	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
种属内	ZBTB43	O43298	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
种属内	ZBTB43	O43298	LNX1	Homo sapiens	Q8TBB1	Y2H Pooling	16189514
种属内	ZBTB43	O43298	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
种属内	ZBTB43	O43298	ZNF417	Homo sapiens	Q8TAU3	Y2H Pooling	16189514
种属内	ZBTB43	O43298	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
种属内	ZBTB43	O43298	ARRB1	Homo sapiens	P49407	Validated Y2H	32296183
种属内	ZBTB43	O43298	ZBTB24	Homo sapiens	O43167	Y2H Array	25416956
种属内	ZBTB43	O43298	ZBTB24	Homo sapiens	O43167	Y2H Prey Pooling	25416956
种属内	ZBTB43	O43298	LMO1	Homo sapiens	P25800	Y2H Prey Pooling	25416956
种属内	ZBTB43	O43298	LMO1	Homo sapiens	P25800	Validated Y2H	25416956
种属内	ZBTB43	O43298	LMO1	Homo sapiens	P25800	Validated Y2H	32296183
种属内	ZBTB43	O43298	LMO1	Homo sapiens	P25800	Y2H Array	25416956
种属内	ZBTB43	O43298	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
种属内	ZBTB43	O43298	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
种属内	ZBTB43	O43298	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Diamond-Blackfan Anemia 4

DBA4	Rps17-Related Diamond-Blackfan Anemia
Anemia, Diamond-Blackfan, Type 4

Spastic Paraplegia 16, X-Linked

SPG16	Hereditary Spastic Paraplegia 16
X-Linked Spastic Paraplegia Type 16	Spastic Paraplegia 16, X-Linked, Complicated
X-Linked Spastic Paraplegia 16	Spastic Paraplegia 16
Spastic Paraplegia-16, X-Linked, Complicated

Spastic Paraplegia 12, Autosomal Dominant

SPG12	Hereditary Spastic Paraplegia 12
Autosomal Dominant Spastic Paraplegia Type 12	Autosomal Dominant Spastic Paraplegia 12
Spastic Paraplegia 12	Spastic Paraplegia-12
Paraplegia, Spastic, Autosomal Dominant, Type 12

Hemochromatosis Type 2

Juvenile Hemochromatosis	Juvenile Hereditary Hemochromatosis
Hfe2	Jhh
Hemochromatosis Juvenile	Iron Overload Disease Juvenile
Hemochromatosis, Juvenile	Hemochromatosis, Type 2
Hemochromatosis	Hemochromatosis, Type 1

Hereditary Spastic Paraplegia 56

Autosomal Recessive Spastic Paraplegia Type 56	Spg56
Autosomal Recessive Spastic Paraplegia 56

Masa Syndrome

L1 Syndrome	Crash Syndrome
X-Linked Hydrocephalus Syndrome	SPG1
Gareis-Mason Syndrome	Spastic Paraplegia 1, X-Linked
Corpus Callosum Hypoplasia-Retardation-Adducted Thumbs-Spasticity-Hydrocephalus Syndrome	L1cam Syndrome
Spastic Paraplegia 1	Mental Retardation, Aphasia, Shuffling Gait, And Adducted Thumbs
Clasped Thumb And Mental Retardation	Thumb, Congenital Clasped, With Mental Retardation
Adducted Thumb With Mental Retardation	Hereditary Spastic Paraplegia 1
X-Linked Complicated Hereditary Spastic Paraplegia Type 1	X-Linked Corpus Callosum Agenesis
X-Linked Spastic Paraplegia 1	L1 Disease
X-Linked Intellectual Disability - Corpus Callosum Agenesis - Spastic Quadriparesis	Adducted Thumb With Intellectual Disability
Clasped Thumb And Intellectual Disability	Intellectual Disability Aphasia Shuffling Gait Adducted Thumbs
Thumb Congenital Clasped With Intellectual Disability	X-Linked Intellectual Disability-Corpus Callosum Agenesis-Spastic Quadriparesis Syndrome
Adducted Thumbs-Mental Retardation Syndrome	Corpus Callosum Hypoplasia, Mental Retardation, Adducted Thumbs, Spastic Paraplegia, Hydrocephalus Syndrome
Mental Retardation-Clasped Thumb Syndrome	Intellectual Disability-Aphasia-Shuffling Gait-Adducted Thumbs Syndrome
Spastic Paraplegia Type 1, X-Linked	MASA
Corpus Callosum Hypoplasia-Psychomotor Retardation, Adducted Thumbs-Spastic Paraparesis-Hydrocephalus	Crash
Masa Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15976	ZBTB43 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	ZBTB43	VGNC	VGNC:37082
Mus musculus	ZBTB43	MGD	MGI:1919084
Rattus norvegicus	ZBTB43	RGD	RGD:1310287
Felis catus	ZBTB43	VGNC	VGNC:67171
Macaca mulatta	ZBTB43	VGNC	VGNC:79101

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4