ARR3 - arrestin 3 Gene

中文名称：抑制素 3

种属: Homo sapiens

同用名: ARRX; cArr; MYP26

基因 ID: 407 | 基因类型: protein coding

关于 ARR3

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,268,334-70,281,883 (from NCBI)

This gene has 4 transcripts (splice variants), 262 orthologues, 3 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是一种非视觉抑制蛋白，可与激动剂激活的磷酸化 G 蛋白偶联受体结合。这种结合将受体与异源三聚体 G 蛋白解偶联，导致 G 蛋白偶联受体信号传导终止。编码的蛋白质也是中心体的一部分，与γ-微管蛋白相互作用，帮助调节适当的中心体功能。[RefSeq 提供，2016 年 5 月]

The protein encoded by this gene is a non-visual Arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]

ARR3 基因产物(1)

mRNA	Protein	Name
NM_004312.3	NP_004303.2	arrestin-C

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in photoreceptor inner segment	IDA IDA: 通过直接分析推断	23704327	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARR3 蛋白结构

Arrestin_N

Arrestin_C

0
100
200
300
388 a.a.

蛋白主名

其他名称

arrestin-C

C-arrestin

ARR3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ARR3	P36575	ZBTB43	Homo sapiens	O43298	Y2H Array	25416956
种属内	ARR3	P36575	ZBTB43	Homo sapiens	O43298	Y2H Prey Pooling	25416956
种属内	ARR3	P36575	ZNF496	Homo sapiens	Q96IT1	Y2H Pooling	16189514
种属内	ARR3	P36575	ZNF496	Homo sapiens	Q96IT1	Pull Down	16189514
种属内	ARR3	P36575	ZNF496	Homo sapiens	Q96IT1	Lumier	32814053
种属内	ARR3	P36575	PLK4	Homo sapiens	O00444	Y2H Array	25416956
种属内	ARR3	P36575	PLK4	Homo sapiens	O00444	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Myopia 26, X-Linked, Female-Limited

MYP26

Myopia, Type 26, X-Linked, Female-Limited

Refractive Error

Refractive Errors

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Oguchi Disease 1

Oguchi Disease-1	CSNBO1
Night Blindness, Congenital Stationary, Oguchi Type 1	Congenital Stationary Night Blindness Oguchi Type 1
Oguchi Disease

Oguchi Disease 2

Oguchi Disease-2	CSNBO2
Night Blindness, Congenital Stationary, Oguchi Type 2	Congenital Stationary Night Blindness Oguchi Type 2

Retinal Vasculitis

Night Blindness, Congenital Stationary, Type 2a

Congenital Stationary Night Blindness 2a	CSNB2A
Csnb2	Csnb, Incomplete, X-Linked
Night Blindness, Congenital Stationary, Type 2	Night Blindness, Congenital Stationary , 2a, X-Linked
Congenital Stationary Night Blindness 2a X-Linked	Night Blindness, Congenital Stationary, 2a
Congenital Stationary Night Blindness Type 2	Incomplete X-Linked Csnb
Night Blindness, Congenital Stationary, X-Linked, Type 2a	Blindness, Night, Stationary, Congenital, Type 2a

Myasthenic Syndrome, Congenital, 3a, Slow-Channel

Congenital Myasthenic Syndrome 3a	CMS3A
Congenital Myasthenic Syndrome 3a, Slow-Channel	Myasthenic Syndrome, Congenital, Type 3a, Slow-Channel

Retinal Degeneration

Degeneration Of Retina

Cone-Rod Dystrophy 6

CORD6	Retinal Cone Dystrophy 2
Rcd2	Dystrophy, Cone-Rod, Type 6
Retinitis Pigmentosa 6	Progressive Cone Degeneration
Cone Dystrophy

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Leber Congenital Amaurosis 1

LCA1	Amaurosis Congenita Of Leber I
Lca	Retinal Blindness, Congenital
Crb	Leber Congenital Amaurosis Type I
Leber Congenital Amaurosis, Type 1	Amaurosis Congenita Of Leber, Type 1

Achromatopsia

Achm	Rod Monochromatism
Total Color Blindness	Rod Monochromacy
Monochromatism	Achromatism
Complete Or Incomplete Color Blindness	Pingelapese Blindness
Achromatopsia 1	Achromatopsia 2
Achromatopsia 3

Color Blindness

Color Vision Defect	Blindness Color
Colour Blindness	Colour Vision Deficiency
Color Vision Deficiency	Color Vision Defects
Defective Color Vision	Vision Defect, Color
Color-Vision Disease	Dyschromatopsia

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Eye Degenerative Disease

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Cone Dystrophy

Retinal Cone Dystrophy	Dystrophy, Cone
Cone Dystrophy 3

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01027	ARR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ARR3	VGNC	VGNC:38135
Felis catus	ARR3	VGNC	VGNC:68258
Mus musculus	ARR3	MGD	MGI:2159617
Rattus norvegicus	ARR3	RGD	RGD:621385
Bos taurus	ARR3	VGNC	VGNC:26168
Macaca mulatta	ARR3	VGNC	VGNC:70020

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ARR3 - arrestin 3 Gene

关于 ARR3

功能概要

ARR3 基因产物(1)

ARR3 蛋白结构

ARR3 蛋白互作信息

关联疾病

直系同源

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ARR3 - arrestin 3 Gene

关于 ARR3

功能概要

ARR3 基因产物(1)

ARR3 蛋白结构

ARR3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

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T

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