1. Gene
  2. PLK4 - polo like kinase 4 Gene

PLK4 - polo like kinase 4 Gene

中文名称:马球样激酶 4

种属: Homo sapiens

同用名: SAK; STK18; MCCRP2

基因 ID: 10733 | 基因类型: protein coding

关于 PLK4

Cytogenetic location: 4q28.1 Genomic coordinates (GRCh38): 4:127,880,893-127,899,224 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues, 4 paralogues and is associated with 5 phenotypes. Biased expression in testis (RPKM 12.2), bone marrow (RPKM 8.2) and 12 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶 polo 家族的成员。该蛋白质定位于中心粒,即在中心体中发现的复杂的基于微管的结构,并在细胞周期中调节中心粒复制。已经为该基因发现了编码不同蛋白质同种型的三种可变剪接转录物变体。[RefSeq 提供,2010 年 6 月]

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

PLK4 基因产物(6)

mRNA Protein Name
NM_001190799.2 NP_001177728.1 serine/threonine-protein kinase PLK4 isoform 2
NM_014264.5 NP_055079.3 serine/threonine-protein kinase PLK4 isoform 1
XM_017007662.2 XP_016863151.1 serine/threonine-protein kinase PLK4 isoform X1
XM_017007663.3 XP_016863152.1 serine/threonine-protein kinase PLK4 isoform X2
XM_005262701.4 XP_005262758.1 serine/threonine-protein kinase PLK4 isoform X3
NM_001190801.2 NP_001177730.1 serine/threonine-protein kinase PLK4 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
21725316 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in centriole replication IDA
IDA: 通过直接分析推断
21059844 GOA
involved in centriole replication IMP
IMP: 通过突变表型推断
21725316 GOA
involved in cilium assembly IMP
IMP: 通过突变表型推断
30804208 GOA
acts upstream of or within positive regulation of centriole replication IDA
IDA: 通过直接分析推断
22349705 GOA
involved in positive regulation of centriole replication IDA
IDA: 通过直接分析推断
27796307 GOA
involved in positive regulation of centriole replication IMP
IMP: 通过突变表型推断
16244668 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
27796307 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centriole IDA
IDA: 通过直接分析推断
16244668 GOA
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
located in procentriole IDA
IDA: 通过直接分析推断
24997597 GOA
part of procentriole replication complex IPI
IPI: 通过物理相互作用推断
24997597 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PLK4 蛋白结构

Pkinase

Pkinase: Protein kinase domain (13 - 265)

POLO_box

POLO_box: POLO box duplicated region (893 - 955)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 970 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase PLK4

Snk akin kinase

serine/threonine-protein kinase 18

serine/threonine-protein kinase Sak

PLK4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PLK4 O00444 OSBPL3 Homo sapiens Q9H4L5 32296183
种属内
PLK4 O00444 OSBPL3 Homo sapiens Q9H4L5 32296183
种属内
PLK4 O00444 OSBPL3 Homo sapiens Q9H4L5 32296183
种属内
PLK4 O00444 GAS8 Homo sapiens O95995 32296183
种属内
PLK4 O00444 ECT2 Homo sapiens Q9H8V3 20348415
种属内
PLK4 O00444 ECT2 Homo sapiens Q9H8V3 20348415
种属内
PLK4 O00444 ECT2 Homo sapiens Q9H8V3 20348415
种属内
PLK4 O00444 TFIP11 Homo sapiens Q9UBB9 32296183
种属内
PLK4 O00444 TFIP11 Homo sapiens Q9UBB9 32296183
种属内
PLK4 O00444 TFIP11 Homo sapiens Q9UBB9 32296183
种属内
PLK4 O00444 DNAJB13 Homo sapiens P59910 32296183
种属内
PLK4 O00444 CEP152 Homo sapiens O94986-3
FPS
24997597
种属内
PLK4 O00444 CEP152 Homo sapiens O94986-3
GMS
24997597
种属内
PLK4 O00444 CEP152 Homo sapiens O94986-3 24997597
种属内
PLK4 O00444 CEP152 Homo sapiens O94986-3 21059844
种属内
PLK4 O00444 CEP152 Homo sapiens O94986-3 24997597
种属内
PLK4 O00444 CEP152 Homo sapiens O94986-3 20852615
种属内
PLK4 O00444 CEP152 Homo sapiens O94986-3 21059844
种属内
PLK4 O00444 CEP152 Homo sapiens O94986-3 24997597
种属内
PLK4 O00444 CEP192 Homo sapiens Q8TEP8-3 24997597
种属内
PLK4 O00444 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
PLK4 O00444 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
PLK4 O00444 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
PLK4 O00444 CEP192 Homo sapiens Q8TEP8 26188084
种属内
PLK4 O00444 YWHAH Homo sapiens Q04917 33961781
种属内
PLK4 O00444 CEP152 Homo sapiens O94986 24997597
种属内
PLK4 O00444 CEP152 Homo sapiens O94986 26496610
种属内
PLK4 O00444 CEP152 Homo sapiens O94986 26188084
种属内
PLK4 O00444 CEP152 Homo sapiens O94986 21059844
种属内
PLK4 O00444 CEP152 Homo sapiens O94986 26188084
种属内
PLK4 O00444 YWHAE Homo sapiens P62258 36931259
种属内
PLK4 O00444 P4HB Homo sapiens P07237 32814053
种属内
PLK4 O00444 P4HB Homo sapiens P07237 32814053
种属内
PLK4 O00444 P4HB Homo sapiens P07237 32814053
种属内
PLK4 O00444 SPAG5 Homo sapiens Q96R06 32296183
种属内
PLK4 O00444 SPAG5 Homo sapiens Q96R06 32296183
种属内
PLK4 O00444 SPAG5 Homo sapiens Q96R06 32296183
种属内
PLK4 O00444 SFN Homo sapiens P31947 16189514
种属内
PLK4 O00444 ARR3 Homo sapiens P36575 25416956
种属内
PLK4 O00444 ELOA Homo sapiens Q14241 25416956
种属内
PLK4 O00444 ELOA Homo sapiens Q14241 25416956
种属内
PLK4 O00444 ELOA Homo sapiens Q14241 32296183
种属内
PLK4 O00444 ELOA Homo sapiens Q14241 25416956
种属内
PLK4 O00444 PLK4 Homo sapiens O00444 16189514
种属内
PLK4 O00444 PLK4 Homo sapiens O00444 24997597
种属内
PLK4 O00444 STIL Homo sapiens Q15468
ITC
26188084
种属内
PLK4 O00444 STIL Homo sapiens Q15468 26188084
种属内
PLK4 O00444 STIL Homo sapiens Q15468 26188084
种属内
PLK4 O00444 STIL Homo sapiens Q15468
IF
26188084
种属内
PLK4 O00444 STIL Homo sapiens Q15468 26188084
种属内
PLK4 O00444 TENT5B Homo sapiens Q96A09 32296183
种属内
PLK4 O00444 AIRIM Homo sapiens Q9NX04 25416956
种属内
PLK4 O00444 ZBTB39 Homo sapiens O15060 32296183
种属内
PLK4 O00444 ZBTB39 Homo sapiens O15060 32296183
种属内
PLK4 O00444 ZBTB39 Homo sapiens O15060 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Microcephaly And Chorioretinopathy, Autosomal Recessive, 2

MCCRP2

Microcephaly And Chorioretinopathy, Autosomal Recessive, Type 2

Microcephaly And Chorioretinopathy 2
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome

Mva Syndrome

Mosaic Variegated Aneuplody Microcephaly Syndrome

Warburton Anyane Yeboa Syndrome

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia

Isolated Growth Hormone Deficiency Type Ia

Primordial Dwarfism

Sexual Ateleiotic Dwarfism

Pituitary Dwarfism I

IGHD1A

Illig-Type Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, Type Ia

Congenital Ighd Type Ia

Congenital Isolated Gh Deficiency Type Ia

Congenital Isolated Growth Hormone Deficiency Type Ia

Pituitary Dwarfism 1

Growth Hormone Deficiency, Isolated, Autosomal Recessive

Autosomal Recessive Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 1a

Congenital Ighd

Congenital Isolated Gh Deficiency

Congenital Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated Autosomal Recessive

Illig Type Growth Hormone Deficiency

Non-Acquired Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, 1a

Growth Hormone Deficiency Isolated Autosomal Recessive

Dwarfism, Primordial

Dwarfism

Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome

Autosomal Recessive Chorioretinopathy-Microcephaly-Intellectual Disability Syndrome

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Spermatogenic Failure 10

SPGF10

Spermatogenic Failure With Defective Sperm Annulus

Spermatogenic Failure, Type 10

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus PLK4 VGNC VGNC:64246
Canis familiaris PLK4 VGNC VGNC:44698
Bos taurus PLK4 VGNC VGNC:33036
Macaca mulatta PLK4 VGNC VGNC:76019
Mus musculus PLK4 MGD MGI:101783
Rattus norvegicus PLK4 RGD RGD:1305390
Others PLK4 NCBI