ECT2 - epithelial cell transforming 2 Gene

中文名称：上皮细胞转化 2

种属: Homo sapiens

同用名: ARHGEF31

基因 ID: 1894 | 基因类型: protein coding

关于 ECT2

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:172,750,726-172,829,265 (from NCBI)

This gene has 16 transcripts (splice variants) and 222 orthologues. Broad expression in testis (RPKM 6.4), colon (RPKM 5.0) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种鸟嘌呤核苷酸交换因子和转化蛋白，与 Rho 特异性交换因子和酵母细胞周期调节因子有关。该基因的表达随着 DNA 合成的开始而升高，并在 G2 和 M 期保持升高。原位杂交分析显示，在再生肝脏中进行有丝分裂的细胞中表达处于高水平。因此，这种蛋白质在肝再生过程中以细胞周期依赖性方式表达，并被认为在胞质分裂的调节中具有重要作用。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2017 年 3 月]

The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

ECT2 基因产物(14)

mRNA	Protein	Name
NM_001258315.2	NP_001245244.1	protein ECT2 isoform a
NM_001258316.2	NP_001245245.1	protein ECT2 isoform b
NM_001349094.2	NP_001336023.1	protein ECT2 isoform c
NM_001349095.2	NP_001336024.1	protein ECT2 isoform c
NM_001349096.2	NP_001336025.1	protein ECT2 isoform c
NM_001349097.2	NP_001336026.1	protein ECT2 isoform d
NM_001349098.2	NP_001336027.1	protein ECT2 isoform a
NM_001349099.2	NP_001336028.1	protein ECT2 isoform a
NM_001349100.2	NP_001336029.1	protein ECT2 isoform a
NM_001349101.2	NP_001336030.1	protein ECT2 isoform e
NM_001349102.2	NP_001336031.1	protein ECT2 isoform f
NM_001349103.2	NP_001336032.1	protein ECT2 isoform g
NM_001349104.2	NP_001336033.1	protein ECT2 isoform g
NM_018098.6	NP_060568.3	protein ECT2 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase activator activity	IMP IMP: 通过突变表型推断	15642749	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: 通过直接分析推断	15254234	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15254234	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	15545273	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of GTPase activity	IDA IDA: 通过直接分析推断	19617897	GOA
involved in activation of GTPase activity	IMP IMP: 通过突变表型推断	19617897	GOA
involved in activation of protein kinase activity	IDA IDA: 通过直接分析推断	15254234	GOA
involved in bicellular tight junction assembly	IMP IMP: 通过突变表型推断	15254234	GOA
involved in cellular response to calcium ion	IDA IDA: 通过直接分析推断	15254234	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: 通过直接分析推断	21373644	GOA
involved in cellular response to ionizing radiation	IDA IDA: 通过直接分析推断	21373644	GOA
involved in mitotic cytokinesis	IMP IMP: 通过突变表型推断	16236794	GOA
involved in positive regulation of GTPase activity	IDA IDA: 通过直接分析推断	17115030	GOA
involved in positive regulation of GTPase activity	IMP IMP: 通过突变表型推断	21373644	GOA
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	21373644	GOA
involved in positive regulation of cytokinesis	IDA IDA: 通过直接分析推断	15545273	GOA
involved in positive regulation of cytokinesis	IMP IMP: 通过突变表型推断	12761501	GOA
involved in positive regulation of mitotic cytokinetic process	IMP IMP: 通过突变表型推断	16236794	GOA
involved in protein homooligomerization	IDA IDA: 通过直接分析推断	15545273	GOA
involved in regulation of attachment of spindle microtubules to kinetochore	IMP IMP: 通过突变表型推断	15642749	GOA
involved in regulation of protein kinase activity	IDA IDA: 通过直接分析推断	15254234	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in bicellular tight junction	IDA IDA: 通过直接分析推断	15254234	GOA
located in cell-cell junction	IDA IDA: 通过直接分析推断	15254234	GOA
part of centralspindlin complex	IDA IDA: 通过直接分析推断	16236794	GOA
located in cleavage furrow	IDA IDA: 通过直接分析推断	16103226	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	16394104	GOA
located in midbody	IDA IDA: 通过直接分析推断	15545273	GOA
located in mitotic spindle	IDA IDA: 通过直接分析推断	15254234	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15254234	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ECT2 蛋白结构

PTCB-BRCT

BRCT

RhoGEF

0
200
400
600
800
914 a.a.

蛋白主名

其他名称

protein ECT2

epithelial cell-transforming sequence 2 oncogene

ECT2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ECT2	Q9H8V3	KIF23	Homo sapiens	Q02241	Anti Bait CoIP	19468300
种属内	ECT2	Q9H8V3	KIF23	Homo sapiens	Q02241	Anti Bait CoIP	22750944
种属内	ECT2	Q9H8V3	NCK1	Homo sapiens	P16333	Peptide Array	17474147
种属内	ECT2	Q9H8V3	CTNNA1	Homo sapiens	P35221	Anti Bait CoIP	22750944
种属内	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Anti Tag CoIP	19468302
种属内	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Y2H	19468300
种属内	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Anti Bait CoIP	19468300
种属内	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	ITC	25068414
种属内	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Pull Down	19468300
种属内	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Anti Bait CoIP	22750944
种属内	ECT2	Q9H8V3	CDH1	Homo sapiens	P12830	Anti Bait CoIP	22750944

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04149	ECT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04150	ECT2L Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ECT2	VGNC	VGNC:72152
Felis catus	ECT2	VGNC	VGNC:61716
Bos taurus	ECT2	VGNC	VGNC:28314
Rattus norvegicus	ECT2	RGD	RGD:1308524
Canis familiaris	ECT2	VGNC	VGNC:40189
Mus musculus	ECT2	MGD	MGI:95281

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ECT2 - epithelial cell transforming 2 Gene

关于 ECT2

功能概要

ECT2 基因产物(14)

ECT2 蛋白结构

ECT2 蛋白互作信息

关联疾病

直系同源

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ECT2 - epithelial cell transforming 2 Gene

关于 ECT2

功能概要

ECT2 基因产物(14)

ECT2 蛋白结构

ECT2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

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J

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