2. Gene
  3. OSBPL3 - oxysterol binding protein like 3 Gene

OSBPL3 - oxysterol binding protein like 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：氧固醇结合蛋白样 3

种属: Homo sapiens

同用名: ORP3; ORP-3; OSBP3

基因 ID: 26031 | 基因类型: protein coding

关于 OSBPL3

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:24,796,537-24,981,845 (from NCBI)

This gene has 14 transcripts (splice variants), 276 orthologues and 11 paralogues. Ubiquitous expression in lymph node (RPKM 4.4), urinary bladder (RPKM 4.1) and 23 other tissues.

功能概要

该基因编码氧固醇结合蛋白 (OSBP) 家族的成员，该家族是一组细胞内脂质受体。大多数成员包含一个 N 端 pleckstrin 同源结构域和一个高度保守的 C 端 OSBP 样甾醇结合结构域。编码的蛋白质参与细胞粘附的调节和肌动蛋白细胞骨架的组织。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 8 月]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin Cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

OSBPL3 基因产物(4)

mRNA Protein Name
NM_015550.4 NP_056365.1 oxysterol-binding protein-related protein 3 isoform a
NM_145320.2 NP_663160.1 oxysterol-binding protein-related protein 3 isoform b
NM_145321.2 NP_663161.1 oxysterol-binding protein-related protein 3 isoform c
NM_145322.2 NP_663162.1 oxysterol-binding protein-related protein 3 isoform d
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cholesterol binding IDA
IDA: 通过直接分析推断
17428193 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22190034 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
14593528 GOA
located in nuclear membrane IDA
IDA: 通过直接分析推断
14593528 GOA
located in perinuclear endoplasmic reticulum IDA
IDA: 通过直接分析推断
14593528 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
14593528 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OSBPL3 蛋白结构

PH_8

PH_8: Pleckstrin homology domain (56 - 143)

Oxysterol_BP

Oxysterol_BP: Oxysterol-binding protein (527 - 869)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 887 a.a.
蛋白主名 其他名称

oxysterol-binding protein-related protein 3

OSBP-related protein 3

OSBPL3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra OSBPL3 Q9H4L5 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Cross OSBPL3 Q9H4L5 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Intra OSBPL3 Q9H4L5 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Erythrokeratodermia Variabilis Et Progressiva 1

Erythrokeratodermia Variabilis

Erythrokeratodermia Variabilis Et Progressiva

Greither Disease

Ekv

Ekvp

PSEK

Erythrokeratodermia Variabilis With Erythema Gyratum Repens

Keratosis Palmoplantaris Transgrediens Et Progrediens

Transgrediens Et Progrediens Palmoplantar Keratoderma

EKVP1

Erythrokeratodermia, Progressive Symmetric

Erythrokeratodermia Figurata, Congenital Familial, In Plaques

Keratoderma Palmoplantaris Transgrediens

Keratosis Extremitatum Hereditaria Progrediens

Erythrokeratodermia Variabilis, Mendes Da Costa Type

Progressive Symmetric Erythrokeratodermia

Erythrokeratodermia Figurata Variabilis

Greither'S Disease

Ekv-P

Erythrokeratodermia Variabilis Of Mendes Da Costa

Progressive Symmetrical Erythrokeratoderma Of Gottron

Progressive Diffuse Ppk

Progressive Diffuse Palmoplantar Keratoderma

Transgrediens Et Progrediens Ppk

Darier-Gottron Disease

Erythrokeratodermia Progressiva Symmetrica

Progressive Symmetric Erythrokeratodermia, Gottron Type

Congenital Familial Erythrokeratodermia Figurata In Plaques

Erythrokeratodermia Progressive Symmetric

Erythrokeratodermia Variabilis Mendes Da Costa Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09841 OSBPL3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus OSBPL3 VGNC VGNC:63979
Canis familiaris OSBPL3 VGNC VGNC:44155
Bos taurus OSBPL3 VGNC VGNC:32462
Rattus norvegicus OSBPL3 RGD RGD:1564287
Mus musculus OSBPL3 MGD MGI:1918970
Macaca mulatta OSBPL3 VGNC VGNC:75623
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