PSMD3 - proteasome 26S subunit, non-ATPase 3 Gene

中文名称：蛋白酶体 26S 亚基，非 ATPase 3

种属: Homo sapiens

同用名: S3; P58; RPN3; TSTA2

基因 ID: 5709 | 基因类型: protein coding

关于 PSMD3

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:39,980,807-39,997,959 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 31.7), brain (RPKM 31.3) and 25 other tissues.

功能概要

26S 蛋白酶体是一种多催化蛋白酶复合物，具有由 2 个复合物、20S 核心和 19S 调节剂组成的高度有序结构。 20S 核心由 28 个不同亚基的 4 个环组成； 2 个环由 7 个α亚基组成，2 个环由 7 个β亚基组成。 19S 调节器由一个包含 6 个 ATP 酶亚基和 2 个非 ATP 酶亚基的碱基和一个包含多达 10 个非 ATP 酶亚基的盖子组成。蛋白酶体以高浓度分布在整个真核细胞中，并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。该基因编码蛋白酶体亚基 S3 家族的一个成员，该家族作为 19S 调节器盖的非 ATP 酶亚基之一发挥作用。该基因中的单核苷酸多态性与中性粒细胞计数有关。[RefSeq 提供，2012 年 7 月]

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the Proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012]

PSMD3 基因产物(1)

mRNA	Protein	Name
NM_002809.4	NP_002800.2	26S proteasome non-ATPase regulatory subunit 3

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15147878	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of proteasome complex	IDA IDA: 通过直接分析推断	17323924	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSMD3 蛋白结构

PCI

Rpn3_C

0
100
200
300
400
500
534 a.a.

蛋白主名

其他名称

26S proteasome non-ATPase regulatory subunit 3

26S proteasome regulatory subunit RPN3

PSMD3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PSMD3	O43242	NFKBIA	Homo sapiens	P25963	Y2H Prey Pooling	32296183
种属内	PSMD3	O43242	NFKBIA	Homo sapiens	P25963	Validated Y2H	32296183
种属内	PSMD3	O43242	NFKBIA	Homo sapiens	P25963	Y2H Array	32296183
种属内	PSMD3	O43242	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	35271311
种属内	PSMD3	O43242	PSMA6	Homo sapiens	P60900	Validated Y2H	32296183
种属内	PSMD3	O43242	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	35271311
种属内	PSMD3	O43242	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	PSMD3	O43242	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	PSMD3	O43242	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	PSMD3	O43242	ZBTB43	Homo sapiens	O43298	Y2H Array	31515488
种属内	PSMD3	O43242	ZBTB43	Homo sapiens	O43298	Validated Y2H	32296183
种属内	PSMD3	O43242	ZBTB43	Homo sapiens	O43298	Y2H Prey Pooling	32296183
种属内	PSMD3	O43242	ZBTB43	Homo sapiens	O43298	Y2H Prey Pooling	25416956
种属内	PSMD3	O43242	ZBTB43	Homo sapiens	O43298	Y2H Array	32296183
种属内	PSMD3	O43242	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	25416956
种属内	PSMD3	O43242	CEP44	Homo sapiens	Q9C0F1	Y2H Array	25416956
种属内	PSMD3	O43242	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	25416956
种属内	PSMD3	O43242	SEM1	Homo sapiens	P60896	Y2H Prey Pooling	25416956
种属内	PSMD3	O43242	SEM1	Homo sapiens	P60896	Validated Y2H	25416956
种属内	PSMD3	O43242	SEM1	Homo sapiens	P60896	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hypothyroidism, Congenital, Nongoitrous, 2

Thyroid Dysgenesis	CHNG2
Thyroid Hypoplasia	Thyroid Hemiagenesis
Thyroid Agenesis	Athyreotic Hypothyroidism
Rtsh	Thyrotropin Resistance
Hypothyroidism, Congenital, Due To Thyroid Dysgenesis Or Hypoplasia	Congenital Nongoitrous Hypothyroidism 2
Thyroid, Ectopic	Hypothyroidism, Congenital, Due To Thyroid Dysgenesis
Hypothyroidism, Athyreotic	Thyrotropin
Resistance To Thyrotropin	Congenital Hypothyroidism Due To Thyroid Dysgenesis Or Hypoplasia
Hypothyroidism, Congenital, Non-Goitrous, 2	Congenital Hypothyroidism Due To Thyroid Dysgenesis
Thyroid-Stimulating Hormone Resistance	Thyroid Ectopic
Ectopic Thyroid	Hypothyroidism, Congenital, Nongoitrous, 3
Thyroid Hormone Resistance Syndrome	Hypothyroidism, Congenital, Nongoitrous, 1

Glioblastoma Proneural Subtype

Inflammatory Bowel Disease 22

IBD22

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11324	PSMD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PSMD3	RGD	RGD:1311470
Macaca mulatta	PSMD3	VGNC	VGNC:76452
Mus musculus	PSMD3	MGD	MGI:98858
Felis catus	PSMD3	VGNC	VGNC:69124
Bos taurus	PSMD3	VGNC	VGNC:33467
Canis familiaris	PSMD3	VGNC	VGNC:45112

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