2. Gene
  3. PSMA6 - proteasome 20S subunit alpha 6 Gene

PSMA6 - proteasome 20S subunit alpha 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白酶体 20S 亚基 alpha 6

种属: Homo sapiens

同用名: IOTA; p27K; PROS27

基因 ID: 5687 | 基因类型: protein coding

关于 PSMA6

Cytogenetic location: 14q13.2 Genomic coordinates (GRCh38): 14:35,278,558-35,317,493 (from NCBI)

This gene has 17 transcripts (splice variants), 272 orthologues, 18 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 34.7), colon (RPKM 23.0) and 25 other tissues.

功能概要

蛋白酶体是一种多催化蛋白酶复合物，具有高度有序的环状 20S 核心结构。核心结构由 28 个不同亚基的 4 个环组成； 2 个环由 7 个α亚基组成，2 个环由 7 个β亚基组成。蛋白酶体以高浓度分布在整个真核细胞中，并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。该基因编码肽酶 T1A 家族的一个成员，即 20S 核心 alpha 亚基。已发现该基因的多个转录变体编码几种不同的亚型。在 Y 染色体上发现了一个假基因。[RefSeq 提供，2013 年 8 月]

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

PSMA6 基因产物(4)

mRNA Protein Name
NM_001282232.1 NP_001269161.1 proteasome subunit alpha type-6 isoform b
NM_001282233.1 NP_001269162.1 proteasome subunit alpha type-6 isoform b
NM_001282234.1 NP_001269163.1 proteasome subunit alpha type-6 isoform c
NM_002791.3 NP_002782.1 proteasome subunit alpha type-6 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NF-kappaB binding IPI
IPI: 通过物理相互作用推断
14743216 GOA
enables RNA binding IDA
IDA: 通过直接分析推断
7681138 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12376572 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
16845397 GOA
involved in proteolysis involved in protein catabolic process IMP
IMP: 通过突变表型推断
16845397 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
34711951 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
34711951 GOA
located in nucleus IDA
IDA: 通过直接分析推断
7681138 GOA
part of proteasome complex IDA
IDA: 通过直接分析推断
17323924 GOA
part of proteasome core complex IDA
IDA: 通过直接分析推断
34711951 GOA
part of proteasome core complex, alpha-subunit complex IDA
IDA: 通过直接分析推断
9096325 GOA
located in ribosome IDA
IDA: 通过直接分析推断
7681138 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSMA6 蛋白结构

Proteasome_A_N

Proteasome_A_N: Proteasome subunit A N-terminal signature (9 - 31)

Proteasome

Proteasome: Proteasome subunit (34 - 220)

  • 0
  • 100
  • 200
  • 246 a.a.
蛋白主名 其他名称

proteasome subunit alpha type-6

27 kDa prosomal protein

PSMA6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PSMA6 P60900 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
Intra PSMA6 P60900 SMCO3 Homo sapiens A2RU48
Y2H Array
32296183
Intra PSMA6 P60900 SMCO3 Homo sapiens A2RU48
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 RTP5 Homo sapiens Q14D33
Y2H Prey Pooling
25416956
Intra PSMA6 P60900 RTP5 Homo sapiens Q14D33
Y2H Array
25416956
Intra PSMA6 P60900 UCHL5 Homo sapiens Q9Y5K5
Anti Tag CoIP
35271311
Intra PSMA6 P60900 C19orf47 Homo sapiens Q8N9M1-2
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 C19orf47 Homo sapiens Q8N9M1-2
Validated Y2H
32296183
Intra PSMA6 P60900 C19orf47 Homo sapiens Q8N9M1-2
Y2H Array
32296183
Intra PSMA6 P60900 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra PSMA6 P60900 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra PSMA6 P60900 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
Intra PSMA6 P60900 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
Intra PSMA6 P60900 RNF170 Homo sapiens Q96K19
Validated Y2H
25416956
Intra PSMA6 P60900 ZKSCAN4 Homo sapiens Q969J2
Validated Y2H
32296183
Intra PSMA6 P60900 ZKSCAN4 Homo sapiens Q969J2
Y2H Array
32296183
Intra PSMA6 P60900 ZKSCAN4 Homo sapiens Q969J2
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 PSMA3 Homo sapiens P25788
Anti Bait CoIP
17948026
Intra PSMA6 P60900 PSMA3 Homo sapiens P25788
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 PSMA3 Homo sapiens P25788
Y2H Array
32296183
Intra PSMA6 P60900 PSMA3 Homo sapiens P25788
Validated Y2H
25416956
Intra PSMA6 P60900 PSMA3 Homo sapiens P25788
Y2H Pooling
16169070
Intra PSMA6 P60900 PSMD3 Homo sapiens O43242
Anti Tag CoIP
35271311
Intra PSMA6 P60900 PSMD3 Homo sapiens O43242
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 PSMD3 Homo sapiens O43242
Y2H Array
32296183
Intra PSMA6 P60900 PSMA4 Homo sapiens P25789
Pull Down
15225636
Intra PSMA6 P60900 PSMA4 Homo sapiens P25789
Anti Bait CoIP
19581590
Intra PSMA6 P60900 PSMA4 Homo sapiens P25789
Anti Bait CoIP
17948026
Intra PSMA6 P60900 POLR2L Homo sapiens P62875
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 POLR2L Homo sapiens P62875
Validated Y2H
32296183
Intra PSMA6 P60900 POLR2L Homo sapiens P62875
Y2H Array
32296183
Intra PSMA6 P60900 ZNF596 Homo sapiens Q8TC21
Validated Y2H
32296183
Intra PSMA6 P60900 ZNF596 Homo sapiens Q8TC21
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 ZNF596 Homo sapiens Q8TC21
Y2H Array
32296183
Intra PSMA6 P60900 CADM1 Homo sapiens Q9BY67
Y2H Array
25416956
Intra PSMA6 P60900 ZBTB44 Homo sapiens Q8NCP5
Validated Y2H
25416956
Intra PSMA6 P60900 ZBTB44 Homo sapiens Q8NCP5
Y2H Array
25416956
Intra PSMA6 P60900 PSMA2 Homo sapiens P25787
Anti Tag CoIP
35271311
Intra PSMA6 P60900 PSMA2 Homo sapiens P25787
Anti Bait CoIP
17948026
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Y2H
14733938
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Pull Down
15225636
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Anti Tag CoIP
35271311
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Anti Bait CoIP
17948026
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Y2H
17948026
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Y2H
15225636
Intra PSMA6 P60900 ERH Homo sapiens P84090
Validated Y2H
32296183
Intra PSMA6 P60900 ERH Homo sapiens P84090
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 ERH Homo sapiens P84090
Y2H Array
32296183
Intra PSMA6 P60900 TSPYL Homo sapiens Q6FI91
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 TSPYL Homo sapiens Q6FI91
Validated Y2H
32296183
Intra PSMA6 P60900 TSPYL Homo sapiens Q6FI91
Y2H Array
32296183
Intra PSMA6 P60900 BRME1 Homo sapiens Q0VDD7
Validated Y2H
25416956
Intra PSMA6 P60900 BRME1 Homo sapiens Q0VDD7
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Combined Oxidative Phosphorylation Deficiency 8

COXPD8

Combined Oxidative Phosphorylation Defect Type 8

Cardiomyopathy, Hypertrophic Mitochondrial, Fatal Infantile

Cardiomyopathy Hypertrophic Mitochondrial Fatal Infantile

Combined Oxidative Phosphorylation Deficiency, Type 8
Renal Wilms' Tumor

Nonanaplastic Renal Wilm'S Tumor

Nonanaplastic Renal Wilm'S Tumour

Nonanaplastic Renal Wilms Tumor

Renal Wilms' Tumour
Arrhythmogenic Right Ventricular Dysplasia, Familial, 11

Arrhythmogenic Right Ventricular Dysplasia 11

ARVD11

Arrhythmogenic Right Ventricular Cardiomyopathy 11

Arvc11

Arrhythmogenic Right Ventricular Dysplasia 11 With Mild Palmoplantar Keratoderma And Woolly Hair

Arrhythmogenic Right Ventricular Dysplasia, Familial, 11, With Mild Palmoplantar Keratoderma And Woolly Hair

Familial Arrhythmogenic Right Ventricular Dysplasia 11

Arrhythmogenic Right Ventricular Dysplasia 11, Familial, And Mild Palmoplantar Keratoderma And Woolly Hair

ARVD11PK

Arvd And Mild Palmoplantar Keratoderma With Or Without Woolly Hair

Dysplasia, Ventricular, Right, Arrhythmogenic, Type 11
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11296 PSMA6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PSMA6 RGD RGD:61849
Felis catus PSMA6 VGNC VGNC:80877
Bos taurus PSMA6 VGNC VGNC:33441
Mus musculus PSMA6 MGD MGI:1347006
Canis familiaris PSMA6 VGNC VGNC:45091
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