POLR2L - RNA polymerase II, I and III subunit L Gene

中文名称：RNA 聚合酶 II、I 和 III 亚基 L

种属: Homo sapiens

同用名: RBP10; RPB10; RPABC5; RPB7.6; hRPB7.6; RPB10beta

基因 ID: 5441 | 基因类型: protein coding

关于 POLR2L

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:839,721-842,529 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 85.5), kidney (RPKM 42.9) and 25 other tissues.

功能概要

该基因编码 RNA 聚合酶 II 的一个亚基，该聚合酶负责在真核生物中合成信使 RNA。该基因的产物包含四个具有非典型锌结合域特征的保守半胱氨酸。与其在酵母中的对应物一样，该亚基可能由其他两种 DNA 指导的 RNA 聚合酶共享。[RefSeq 提供，2008 年 7 月]

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

POLR2L 基因产物(1)

mRNA	Protein	Name
NM_021128.5	NP_066951.1	DNA-directed RNA polymerases I, II, and III subunit RPABC5

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21988832	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	34675218	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9852112	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase I complex	IDA IDA: 通过直接分析推断	34671025	GOA
part of RNA polymerase II, core complex	IDA IDA: 通过直接分析推断	9852112	GOA
part of RNA polymerase III complex	IDA IDA: 通过直接分析推断	33335104	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9852112	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POLR2L 蛋白结构

RNA_pol_N

0
67 a.a.

蛋白主名

其他名称

DNA-directed RNA polymerases I, II, and III subunit RPABC5

DNA-directed RNA polymerase III subunit L

POLR2L 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	POLR2L	P62875	TP53BP2	Homo sapiens	Q13625-3	Y2H Array	25416956
Intra	POLR2L	P62875	ZBTB14	Homo sapiens	O43829	Y2H Array	25416956
Intra	POLR2L	P62875	RPAP1	Homo sapiens	Q9BWH6	Anti Tag CoIP	33961781
Intra	POLR2L	P62875	RPAP1	Homo sapiens	Q9BWH6	Y2H Array	25416956
Intra	POLR2L	P62875	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	POLR2L	P62875	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	POLR2L	P62875	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	POLR2L	P62875	FAM217B	Homo sapiens	Q9NTX9	Y2H Array	32296183
Intra	POLR2L	P62875	FAM217B	Homo sapiens	Q9NTX9	Y2H Prey Pooling	32296183
Intra	POLR2L	P62875	FAM217B	Homo sapiens	Q9NTX9	Validated Y2H	32296183
Intra	POLR2L	P62875	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	POLR2L	P62875	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183
Intra	POLR2L	P62875	TRIP13	Homo sapiens	Q15645	Validated Y2H	32296183
Intra	POLR2L	P62875	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183
Intra	POLR2L	P62875	POLR2D	Homo sapiens	O15514	Anti Tag CoIP	33961781
Intra	POLR2L	P62875	POLR2D	Homo sapiens	O15514	Y2H	21988832
Intra	POLR2L	P62875	SPAG5	Homo sapiens	Q96R06	Validated Y2H	25416956
Intra	POLR2L	P62875	SPAG5	Homo sapiens	Q96R06	Y2H Array	25416956
Intra	POLR2L	P62875	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	POLR2L	P62875	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	POLR2L	P62875	BANP	Homo sapiens	Q8N9N5	Y2H Prey Pooling	25416956
Intra	POLR2L	P62875	BANP	Homo sapiens	Q8N9N5	Validated Y2H	25416956
Intra	POLR2L	P62875	NACC1	Homo sapiens	Q96RE7	Y2H Array	32296183
Intra	POLR2L	P62875	NACC1	Homo sapiens	Q96RE7	Y2H Prey Pooling	32296183
Intra	POLR2L	P62875	NACC1	Homo sapiens	Q96RE7	Validated Y2H	32296183
Intra	POLR2L	P62875	COIL	Homo sapiens	P38432	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Hyperparathyroidism 2 With Jaw Tumors

Hyperparathyroidism-Jaw Tumor Syndrome	Hpt-Jt
HRPT2	Familial Primary Hyperparathyroidism With Multiple Ossifying Jaw Fibromas
Parathyroid Adenoma With Cystic Changes	Hereditary Hyperparathyroidism-Jaw Tumor Syndrome
Hyperparathyroidism 2	Hyperparathyroidism, Familial Primary, With Multiple Ossifying Jaw Fibromas
Hyperparathyroidism-Jaw Tumor Syndrome, Hereditary	Familial Cystic Parathyroid Adenomatosis
Hyperparathyroidism-Jaw Tumor Syndrome, Type 2	Parathyroid Adenomatosis, Familial Cystic

Hepatitis D

Delta Hepatitis	Hepatitis Delta
Hdv	Hepatitis D Virus
Hepatitis D Infection

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Rapp-Hodgkin Syndrome

RHS	Anhidrotic Ectodermal Dysplasia With Cleft Lip/Palate
Ectodermal Dysplasia, Rapp-Hodgkin Type	Rapp-Hodgkin Ectodermal Dysplasia Syndrome
Ectodermal Dysplasia, Anhidrotic, With Cleft Lip/Palate	Ectodermal Dysplasia Syndrome, Rapp-Hodgkin Type
Edrh	Rapp-Hodgkin Ectodermal Dysplasia
Orofacial Cleft 8

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10854	POLR2L Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	POLR2L	MGD	MGI:1913741
Rattus norvegicus	POLR2L	RGD	RGD:1566209
Felis catus	POLR2L	VGNC	VGNC:105827
Bos taurus	POLR2L	VGNC	VGNC:33144

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