1. Gene
  2. POLR2D - RNA polymerase II subunit D Gene

POLR2D - RNA polymerase II subunit D Gene

中文名称:RNA 聚合酶 II 亚基 D

种属: Homo sapiens

同用名: RBP4; RPB4; RPB16; HSRBP4; HSRPB4

基因 ID: 5433 | 基因类型: protein coding

关于 POLR2D

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,843,553-127,858,155 (from NCBI)

This gene has 4 transcripts (splice variants) and 205 orthologues. Broad expression in testis (RPKM 27.2), lymph node (RPKM 9.2) and 25 other tissues.

功能概要

该基因编码 RNA 聚合酶 II 的第四大亚基,该聚合酶负责在真核生物中合成信使 RNA。在酵母中,这种聚合酶亚基与次优生长条件下的聚合酶相关,可能具有应激保护作用。核糖体假基因的序列包含在该基因转录物的 3' 非翻译区内。[RefSeq 提供,2008 年 7 月]

This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008]

POLR2D 基因产物(1)

mRNA Protein Name
NM_004805.4 NP_004796.1 DNA-directed RNA polymerase II subunit RPB4

POLR2D 蛋白结构

RNA_pol_Rpb4

RNA_pol_Rpb4: RNA polymerase Rpb4 (32 - 136)

  • 0
  • 100
  • 142 a.a.
蛋白主名 其他名称

DNA-directed RNA polymerase II subunit RPB4

DNA-directed RNA polymerase II 16 kDa polypeptide

POLR2D 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
POLR2D O15514 POLR2L Homo sapiens P62875
Anti Tag CoIP
28514442
种属内
POLR2D O15514 POLR2L Homo sapiens P62875
TAP
24981860
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nemaline Myopathy 7

NEM7

Nemaline Myopathy 7, Autosomal Recessive

Cfl2-Related Nemaline Myopathy

Myopathy, Nemaline, Type 7

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris POLR2D VGNC VGNC:44795
Felis catus POLR2D VGNC VGNC:68949
Mus musculus POLR2D MGD MGI:1916491
Macaca mulatta POLR2D VGNC VGNC:76213
Bos taurus POLR2D VGNC VGNC:33138
Rattus norvegicus POLR2D RGD RGD:1308565