2. Gene
  3. COIL - coilin Gene

COIL - coilin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：线圈素

种属: Homo sapiens

同用名: CLN80; p80-coilin

基因 ID: 8161 | 基因类型: protein coding

关于 COIL

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:56,938,199-56,961,050 (from NCBI)

This gene has 2 transcripts (splice variants) and 202 orthologues. Broad expression in testis (RPKM 65.0), thyroid (RPKM 8.3) and 22 other tissues.

功能概要

该基因编码的蛋白质是 Cajal 体 (也称为卷曲体) 的组成部分。 Cajal 体是不同数量和组成的核亚细胞器，参与小核和小核仁 RNA 的转录后修饰。 coilin 蛋白的 N 端指导其自身寡聚化，而 C 端影响每个细胞组装的核体数量。 coilin 的差异甲基化和磷酸化可能影响其在核体中的定位以及 Cajal 体的组成和组装。该基因在 4 号染色体和 14 号染色体上有假基因。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

COIL 基因产物(1)

mRNA Protein Name
NM_004645.3 NP_004636.1 coilin
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16713569 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12757932 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Cajal body IDA
IDA: 通过直接分析推断
12757932 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
12757932 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
12757932 GOA
located in nucleus IDA
IDA: 通过直接分析推断
19734146 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

coilin

coilin p80

COIL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra COIL P38432 ZNF277 Homo sapiens Q8WWA6
Y2H Array
25416956
Intra COIL P38432 MFAP1 Homo sapiens P55081
Y2H Prey Pooling
25416956
Intra COIL P38432 CCDC57 Homo sapiens Q2TAC2-2
Validated Y2H
32296183
Intra COIL P38432 SPANXN2 Homo sapiens Q5MJ10
Validated Y2H
32296183
Intra COIL P38432 ADAMTS12 Homo sapiens P58397-3
Validated Y2H
32296183
Intra COIL P38432 PDE4D Homo sapiens Q08499
Y2H Prey Pooling
25416956
Intra COIL P38432 PDE4D Homo sapiens Q08499
Validated Y2H
25416956
Intra COIL P38432 VRK1 Homo sapiens Q99986
Anti Tag CoIP
21920476
Intra COIL P38432 VRK1 Homo sapiens Q99986
Peptide Array
21920476
Intra COIL P38432 VRK1 Homo sapiens Q99986
Confocal
21920476
Intra COIL P38432 ANKS1B Homo sapiens Q7Z6G8-2
Anti Tag CoIP
15862129
Intra COIL P38432 ANKS1B Homo sapiens Q7Z6G8-2
Pull Down
15862129
Intra COIL P38432 ANKS1B Homo sapiens Q7Z6G8-1
Anti Bait CoIP
15862129
Intra COIL P38432 ANKS1B Homo sapiens Q7Z6G8-1
Pull Down
15862129
Intra COIL P38432 DYNC2I2 Homo sapiens Q96EX3
Validated Y2H
25416956
Intra COIL P38432 ARMCX1 Homo sapiens Q9P291
Validated Y2H
25416956
Intra COIL P38432 ARMCX1 Homo sapiens Q9P291
Y2H Array
25416956
Intra COIL P38432 AK6 Homo sapiens Q9Y3D8
Anti Tag CoIP
16079131
Intra COIL P38432 AK6 Homo sapiens Q9Y3D8
Y2H
16079131
Intra COIL P38432 AK6 Homo sapiens Q9Y3D8
Pull Down
16079131
Intra COIL P38432 C9orf72 Homo sapiens Q96LT7
Validated Y2H
32296183
Intra COIL P38432 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra COIL P38432 XRCC6 Homo sapiens P12956
Pull Down
21070772
Intra COIL P38432 PSME3 Homo sapiens P61289
Y2H Array
16713569
Intra COIL P38432 PSME3 Homo sapiens P61289
Validated Y2H
32296183
Intra COIL P38432 PSME3 Homo sapiens P61289
Y2H
16713569
Intra COIL P38432 SNRPF Homo sapiens P62306
Validated Y2H
32296183
Intra COIL P38432 SNRPF Homo sapiens P62306
Y2H Array
25416956
Intra COIL P38432 XRCC5 Homo sapiens P13010
Pull Down
21070772
Intra COIL P38432 XRCC5 Homo sapiens P13010
Competition Binding
21070772
Intra COIL P38432 BYSL Homo sapiens Q13895
Validated Y2H
32296183
Intra COIL P38432 POLR2L Homo sapiens P62875
Validated Y2H
25416956
Intra COIL P38432 POLR2L Homo sapiens P62875
Y2H Array
25416956
Intra COIL P38432 NKAPD1 Homo sapiens Q6ZUT1
Validated Y2H
32296183
Intra COIL P38432 SMN1 Homo sapiens Q16637
Anti Bait CoIP
21072240
Intra COIL P38432 SMN1 Homo sapiens Q16637
Pull Down
21070772
Intra COIL P38432 POLR3C Homo sapiens Q9BUI4
Validated Y2H
32296183
Intra COIL P38432 SRPK2 Homo sapiens P78362
Validated Y2H
32296183
Intra COIL P38432 FGF12 Homo sapiens P61328
Y2H Prey Pooling
25416956
Intra COIL P38432 PTS Homo sapiens Q03393
Y2H Array
25416956
Intra COIL P38432 PTS Homo sapiens Q03393
Y2H Prey Pooling
25416956
Intra COIL P38432 PTS Homo sapiens Q03393
Validated Y2H
25416956
Intra COIL P38432 DRG1 Homo sapiens Q9Y295
Y2H Array
25416956
Intra COIL P38432 NFU1 Homo sapiens Q9UMS0
Validated Y2H
32296183
Intra COIL P38432 CEP70 Homo sapiens Q8NHQ1
Y2H Array
16713569
Intra COIL P38432 CEP70 Homo sapiens Q8NHQ1
Y2H
16713569
Intra COIL P38432 LNX1 Homo sapiens Q8TBB1
Pull Down
16713569
Intra COIL P38432 PDLIM5 Homo sapiens Q96HC4
Y2H Array
31515488
Intra COIL P38432 PDLIM5 Homo sapiens Q96HC4
Y2H Prey Pooling
25416956
Intra COIL P38432 PDLIM5 Homo sapiens Q96HC4
Y2H Array
25416956
Intra COIL P38432 PICK1 Homo sapiens Q9NRD5
Y2H
16713569
Intra COIL P38432 PDE4D Homo sapiens Q08499-8
Validated Y2H
32296183
Intra COIL P38432 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra COIL P38432 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra COIL P38432 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra COIL P38432 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra COIL P38432 ATXN1 Homo sapiens P54253-1
IF
12757932
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]
Actinomycosis

Actinomycetoma

Boil

Canaliculitis

Actinomycotic Infection

Actinomycotic Madura Foot

Keratoactinomycosis

Furuncle

Actinomycotic Mycetema

Actinomycotic Mycetoma Of Foot

Madura Foot Due To Actinomadura

Actinomyces Israeli

Actinomycetes

Anaerobic Actinomyces Infection

Actinomycotic Infection Of Unspecified Site

Actinomycosis Nos

Actinomycotic Node

Actinomyces Infection

Actinomycotic Mycetoma

Mycetoma Due To Filamentous Bacteria
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
Differentiating Neuroblastoma
Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-148808 Zelasudil Inhibitor 99.86% Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10996A KHS101 hydrochloride 99.84% 否
HY-135960 BO-264 99.63% 否
HY-18990 GSK180736A Inhibitor 98.01% 否
HY-118046 GSK2163632A Inhibitor / 否
HY-118837 WF-536 Inhibitor / 否
HY-150536 EP39 Inhibitor / 否
HY-RS02958 COIL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus COIL RGD RGD:62031
Felis catus COIL VGNC VGNC:61051
Mus musculus COIL MGD MGI:104842
Bos taurus COIL VGNC VGNC:27552
Canis familiaris COIL VGNC VGNC:39454
Others COIL NCBI
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