2. Gene
  3. DRG1 - developmentally regulated GTP binding protein 1 Gene

DRG1 - developmentally regulated GTP binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：发育调节的 GTP 结合蛋白 1

种属: Homo sapiens

同用名: NEDD3

基因 ID: 4733 | 基因类型: protein coding

关于 DRG1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,399,604-31,434,452 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues and 4 paralogues. Broad expression in testis (RPKM 112.9), thyroid (RPKM 23.8) and 24 other tissues.

功能概要

启用多项功能，包括 GTPase 活动；相同的蛋白质结合活性；和钾离子结合活性。参与微管聚合的正调控和有丝分裂纺锤体组装的调控。位于细胞质和核体中。多核糖体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including GTPase activity; identical protein binding activity; and potassium ion binding activity. Involved in positive regulation of microtubule polymerization and regulation of mitotic spindle assembly. Located in cytosol and nuclear body. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]

DRG1 基因产物(1)

mRNA Protein Name
NM_004147.4 NP_004138.1 developmentally-regulated GTP-binding protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activity IDA
IDA: 通过直接分析推断
23711155 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
23711155 GOA
enables microtubule binding IDA
IDA: 通过直接分析推断
28855639 GOA
enables potassium ion binding IDA
IDA: 通过直接分析推断
23711155 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of microtubule polymerization IMP
IMP: 通过突变表型推断
28855639 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: 通过突变表型推断
28855639 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19819225 GOA
located in nucleus IDA
IDA: 通过直接分析推断
29915238 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DRG1 蛋白结构

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (66 - 165)

TGS

TGS: TGS domain (292 - 366)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
蛋白主名 其他名称

developmentally-regulated GTP-binding protein 1

DRG-1

DRG1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Anti Tag CoIP
28514442
种属内
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Y2H Array
25416956
种属内
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Y2H Array
32296183
种属内
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Y2H Prey Pooling
25416956
种属内
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Anti Tag CoIP
35271311
种属内
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Y2H Prey Pooling
32296183
种属内
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Y2H
21516116
种属内
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Anti Tag CoIP
33961781
种属内
DRG1 Q9Y295 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
DRG1 Q9Y295 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
DRG1 Q9Y295 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
25416956
种属内
DRG1 Q9Y295 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
种属内
DRG1 Q9Y295 SSX2IP Homo sapiens Q9Y2D8
Y2H Prey Pooling
25416956
种属内
DRG1 Q9Y295 SKIL Homo sapiens P12757
Y2H Array
25416956
种属内
DRG1 Q9Y295 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
种属内
DRG1 Q9Y295 PHC2 Homo sapiens Q8IXK0
Y2H Array
25416956
种属内
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Y2H Prey Pooling
32296183
种属内
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Y2H Array
25416956
种属内
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Y2H Array
32296183
种属内
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Y2H Pooling
16189514
种属内
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Pull Down
16189514
种属内
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Y2H Prey Pooling
25416956
种属内
DRG1 Q9Y295 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
种属内
DRG1 Q9Y295 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
种属内
DRG1 Q9Y295 STK16 Homo sapiens O75716
Y2H Prey Pooling
25416956
种属内
DRG1 Q9Y295 COIL Homo sapiens P38432
Validated Y2H
25416956
种属内
DRG1 Q9Y295 COIL Homo sapiens P38432
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Charcot-Marie-Tooth Disease, X-Linked Recessive, 5

CMTX5

Rosenberg-Chutorian Syndrome

Charcot-Marie-Tooth Disease X-Linked Recessive 5

Optic Atrophy, Polyneuropathy, And Deafness

Charcot-Marie-Tooth Neuropathy X-Linked Recessive 5

Cmt5x

X-Linked Charcot-Marie-Tooth Disease Type 5

Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 5

Optic Atrophy Polyneuropathy Deafness

Optic Atrophy With Polyneuropathy And Deafness

Charcot-Marie-Tooth Disease, X-Linked Recessive, Type 5
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04009 DRG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta DRG1 VGNC VGNC:84729
Felis catus DRG1 VGNC VGNC:61630
Canis familiaris DRG1 VGNC VGNC:40097
Rattus norvegicus DRG1 RGD RGD:1304993
Bos taurus DRG1 VGNC VGNC:53899
Mus musculus DRG1 MGD MGI:1343297
Others DRG1 NCBI
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