2. Gene
  3. SKIL - SKI like proto-oncogene Gene

SKIL - SKI like proto-oncogene Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SKI 样原癌基因

种属: Homo sapiens

同用名: SNO; SnoA; SnoI; SnoN

基因 ID: 6498 | 基因类型: protein coding

关于 SKIL

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:170,357,715-170,396,849 (from NCBI)

This gene has 10 transcripts (splice variants), 221 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 14.0), appendix (RPKM 11.3) and 25 other tissues.

功能概要

该基因编码的蛋白质是 SMAD 通路的一个组成部分，它通过转化生长因子-β (TGFB) 调节细胞生长和分化。在没有配体的情况下，编码的蛋白质与 TGFB 反应基因的启动子区域结合并募集核抑制复合物。 TGFB 信号导致 SMAD3 进入细胞核并降解该蛋白质，从而激活这些基因。已发现该基因编码三种不同亚型的四种转录变体。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SKIL 基因产物(4)

mRNA Protein Name
NM_001145097.2 NP_001138569.1 ski-like protein isoform 2
NM_001145098.3 NP_001138570.1 ski-like protein isoform 3
NM_001248008.1 NP_001234937.1 ski-like protein isoform 1
NM_005414.5 NP_005405.2 ski-like protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10531062 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10531062 GOA
enables SMAD binding IPI
IPI: 通过物理相互作用推断
12764135 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
8514802 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8514802 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
18334480 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
18334480 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10531062 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
17469184 GOA
involved in positive regulation of axonogenesis IMP
IMP: 通过突变表型推断
16675394 GOA
involved in response to antibiotic IEP
IEP: 通过表达模式推断
15967445 GOA
involved in response to growth factor IDA
IDA: 通过直接分析推断
19383336 GOA
involved in skeletal muscle tissue development IDA
IDA: 通过直接分析推断
17202138 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
19383336 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
16109768 GOA
located in nucleus IDA
IDA: 通过直接分析推断
14712482 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
23610558 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SKIL 蛋白结构

Ski_Sno

Ski_Sno: SKI/SNO/DAC family (125 - 235)

c-SKI_SMAD_bind

c-SKI_SMAD_bind: c-SKI Smad4 binding domain (261 - 356)

  • 0
  • 200
  • 400
  • 600
  • 684 a.a.
蛋白主名 其他名称

ski-like protein

SKI-like oncogene

SKIL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SKIL P12757 VPS28 Homo sapiens Q548N1
Y2H Prey Pooling
25416956
种属内
SKIL P12757 SMAD2 Homo sapiens Q15796
Y2H
15231748
种属内
SKIL P12757 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
种属内
SKIL P12757 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
种属内
SKIL P12757 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
种属内
SKIL P12757 XPA Homo sapiens P23025
Validated Y2H
32296183
种属内
SKIL P12757 VIM Homo sapiens P08670
Y2H Array
32814053
种属内
SKIL P12757 VIM Homo sapiens P08670
Y2H Pooling
32814053
种属内
SKIL P12757 VIM Homo sapiens P08670
Validated Y2H
32814053
种属内
SKIL P12757 NEFL Homo sapiens P07196
Validated Y2H
32814053
种属内
SKIL P12757 NEFL Homo sapiens P07196
Y2H Array
32814053
种属内
SKIL P12757 NEFL Homo sapiens P07196
Y2H Pooling
32814053
种属内
SKIL P12757 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
SKIL P12757 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
SKIL P12757 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
SKIL P12757 OIP5 Homo sapiens O43482
Y2H Array
25416956
种属内
SKIL P12757 PECAM1 Homo sapiens P16284
Y2H Array
32814053
种属内
SKIL P12757 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
种属内
SKIL P12757 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
种属内
SKIL P12757 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
种属内
SKIL P12757 DRG1 Homo sapiens Q9Y295
Y2H Prey Pooling
25416956
种属内
SKIL P12757 DRG1 Homo sapiens Q9Y295
Validated Y2H
25416956
种属内
SKIL P12757 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
SKIL P12757 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
SKIL P12757 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
SKIL P12757 VPS28 Homo sapiens Q9UK41
Y2H
21516116
种属内
SKIL P12757 DEUP1 Homo sapiens Q05D60
Validated Y2H
32296183
种属内
SKIL P12757 STK16 Homo sapiens O75716
Y2H Array
25416956
种属内
SKIL P12757 NXF3 Homo sapiens Q9H4D5
Y2H Array
25416956
种属内
SKIL P12757 ATP1A3 Homo sapiens P13637
Y2H Pooling
32814053
种属内
SKIL P12757 ATP1A3 Homo sapiens P13637
Validated Y2H
32814053
种属内
SKIL P12757 ATP1A3 Homo sapiens P13637
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Obstructive Nephropathy

Con

Congenital Obstructive Nephropathy

Nephropathy Obstructive
Cornea Cancer

Malignant Neoplasm Of Cornea

Neoplasm Of Cornea

Corneal Tumor

Malignant Corneal Tumor

Malignant Tumor Of Cornea

Primary Malignant Neoplasm Of Cornea
Renal Fibrosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12970 SKIL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SKIL VGNC VGNC:65171
Macaca mulatta SKIL VGNC VGNC:84081
Canis familiaris SKIL VGNC VGNC:46199
Mus musculus SKIL MGD MGI:106203
Rattus norvegicus SKIL RGD RGD:621399
Bos taurus SKIL VGNC VGNC:34648
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