NXF3 - nuclear RNA export factor 3 Gene

中文名称：核 RNA 输出因子 3

种属: Homo sapiens

关于 NXF3

功能概要

该基因是核 RNA 输出因子基因家族的成员之一。该家族的共同结构域特征是非经典 RNP 型 RNA 结合结构域 (RBD) 、4 个富含亮氨酸的重复序列 (LRR) 、允许与 NTF2 相关输出蛋白异二聚化的核转运因子 2 (NTF2) 样结构域- 1 (NXT1) ，以及介导与核孔蛋白相互作用的泛素相关结构域。出口活动需要 LRR 和类似 NTF2 的域。可变剪接似乎是该基因家族中的一种常见机制。该基因编码的蛋白质具有缩短的 LRR 和泛素相关结构域，其 RDB 不能结合 RNA。它位于核质中，但不与核包膜或核仁相关。[RefSeq 提供，2008 年 7 月]

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]