NXT1 - nuclear transport factor 2 like export factor 1 Gene

中文名称：核运输因子 2 就样出口因子 1

种属: Homo sapiens

同用名: P15; MTR2

关于 NXT1

功能概要

该基因编码的蛋白质位于核膜中。它与核转运因子 2 具有蛋白质相似性。该蛋白质在 RAN (Ras 相关核蛋白) 和 CRM1 (染色体区域维持所需) 依赖性途径中充当核输出因子。它被发现可以刺激 RAN 和 CRM1 依赖性通路中 U1 snRNA 的输出，以及 CRM1 非依赖性通路中 tRNA 和 mRNA 的输出。编码的蛋白质与 Tap 蛋白异二聚化，并可能调节 Tap 蛋白介导核 mRNA 输出的能力。已发现该基因使用替代聚腺苷酸化位点。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]