STAU1 - staufen double-stranded RNA binding protein 1 Gene

中文名称：诗道芬双链 RNA 结合蛋白 1

种属: Homo sapiens

同用名: STAU; PPP1R150

基因 ID: 6780 | 基因类型: protein coding

关于 STAU1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,113,339-49,219,295 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 14 paralogues. Ubiquitous expression in kidney (RPKM 41.4), thyroid (RPKM 35.8) and 25 other tissues.

功能概要

Staufen 是双链 RNA (dsRNA) 结合蛋白家族的成员，参与将 mRNA 运输和/或定位到不同的亚细胞区室和/或细胞器。这些蛋白质的特征在于存在多个 dsRNA 结合域，这些域是结合具有双链二级结构的 RNA 所必需的。由 STAU 编码的 staufen 人类同系物另外包含一个类似于微管相关蛋白 1B 的微管结合结构域，并结合微管蛋白。 STAU 基因产物已被证明存在于与粗面内质网 (RER) 相关的细胞质中，表明该蛋白质参与了 mRNA 通过微管网络向 RER (翻译位点) 的转运。[RefSeq 提供，2020 年 4 月]

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]

STAU1 基因产物(14)

mRNA	Protein	Name
NM_001037328.3	NP_001032405.1	double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001319134.2	NP_001306063.1	double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001319135.2	NP_001306064.1	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322927.2	NP_001309856.1	double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001322928.2	NP_001309857.1	double-stranded RNA-binding protein Staufen homolog 1 isoform d
NM_001322929.2	NP_001309858.1	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322930.2	NP_001309859.1	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322931.2	NP_001309860.1	double-stranded RNA-binding protein Staufen homolog 1 isoform e
NM_001322932.2	NP_001309861.1	double-stranded RNA-binding protein Staufen homolog 1 isoform f
NM_001322933.2	NP_001309862.1	double-stranded RNA-binding protein Staufen homolog 1 isoform f
NM_004602.4	NP_004593.2	double-stranded RNA-binding protein Staufen homolog 1 isoform a
NM_017452.4	NP_059346.2	double-stranded RNA-binding protein Staufen homolog 1 isoform a
NM_017453.4	NP_059347.2	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_017454.4	NP_059348.2	double-stranded RNA-binding protein Staufen homolog 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15121898	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation by virus of viral protein levels in host cell	IMP IMP: 通过突变表型推断	23907398	GOA
involved in positive regulation of viral genome replication	IMP IMP: 通过突变表型推断	23907398	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell body	IDA IDA: 通过直接分析推断	15121898	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	19029303	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: 通过直接分析推断	15121898	GOA
located in dendrite	IDA IDA: 通过直接分析推断	15121898	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	23907398	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	22978549	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STAU1 蛋白结构

dsrm

0
100
200
300
400
500
577 a.a.

蛋白主名

其他名称

double-stranded RNA-binding protein Staufen homolog 1

protein phosphatase 1, regulatory subunit 150

STAU1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	STAU1	O95793	ADARB1	Homo sapiens	P78563-4	Validated Y2H	32296183
Intra	STAU1	O95793	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	32296183
Intra	STAU1	O95793	LONRF1	Homo sapiens	Q17RB8	Y2H Array	25416956
Intra	STAU1	O95793	ZMAT3	Homo sapiens	Q9HA38	Y2H Array	25416956
Intra	STAU1	O95793	NXT1	Homo sapiens	Q9UKK6	Y2H Prey Pooling	25416956
Intra	STAU1	O95793	NXT1	Homo sapiens	Q9UKK6	Validated Y2H	32296183
Intra	STAU1	O95793	NXT1	Homo sapiens	Q9UKK6	Y2H Array	25416956
Cross	STAU1	O95793	Klf4	Mus musculus	Q60793	Anti Tag CoIP	29374155
Intra	STAU1	O95793	RPLP0	Homo sapiens	P05388	Affinity Chrom	15303970
Intra	STAU1	O95793	RPLP0	Homo sapiens	P05388	TAP	15121898
Intra	STAU1	O95793	RPL7A	Homo sapiens	P62424	Affinity Chrom	15303970
Intra	STAU1	O95793	RPL7A	Homo sapiens	P62424	Anti Tag CoIP	33961781
Intra	STAU1	O95793	UPF1	Homo sapiens	Q92900	Anti Tag CoIP	23722113
Intra	STAU1	O95793	UPF1	Homo sapiens	Q92900	Complementation	15680326
Intra	STAU1	O95793	UPF1	Homo sapiens	Q92900	Far-WB	15680326
Intra	STAU1	O95793	UPF1	Homo sapiens	Q92900	Pull Down	15680326
Intra	STAU1	O95793	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
Intra	STAU1	O95793	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	25416956
Intra	STAU1	O95793	GLRX3	Homo sapiens	O76003	Validated Y2H	25416956
Intra	STAU1	O95793	STRBP	Homo sapiens	Q96SI9	Validated Y2H	32296183
Cross	STAU1	O95793	NS	Influenza A virus	P03496	Y2H Array	23853584

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Philophthalmiasis

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Intellectual Developmental Disorder, Autosomal Dominant 1

MRD1	Autosomal Dominant Non-Syndromic Intellectual Disability 1
Mental Retardation, Autosomal Dominant 1	Autosomal Dominant Intellectual Developmental Disorder 1

Meckel Diverticulum

Meckel'S Diverticulum

Persistent Vitelline Duct

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13900	STAU1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	STAU1	MGD	MGI:1338864
Canis familiaris	STAU1	VGNC	VGNC:46893
Macaca mulatta	STAU1	VGNC	VGNC:77909
Rattus norvegicus	STAU1	RGD	RGD:621778
Bos taurus	STAU1	VGNC	VGNC:35375
Felis catus	STAU1	VGNC	VGNC:65764

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

STAU1 - staufen double-stranded RNA binding protein 1 Gene

关于 STAU1

功能概要

STAU1 基因产物(14)

STAU1 蛋白结构

STAU1 蛋白互作信息

关联疾病

直系同源

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STAU1 - staufen double-stranded RNA binding protein 1 Gene

关于 STAU1

功能概要

STAU1 基因产物(14)

STAU1 蛋白结构

STAU1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z