Klf4 - Kruppel-like factor 4 (gut) Gene

种属: Mus musculus

同用名: EZF; Zie; Gklf

基因 ID: 16600 | 基因类型: protein coding

关于 Klf4

功能概要

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; and beta-catenin binding activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of core promoter binding activity; and transcription, DNA-templated. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of blastocyst development; and regulation of transcription, DNA-templated. Located in cytoplasm; euchromatin; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (Kruppel like factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Klf4 基因产物(1)

mRNA	Protein	Name
NM_010637.3	NP_034767.2	Krueppel-like factor 4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	22306741	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	22723415	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	17130451	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	28262547	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	22723415	MGI
enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	IDA IDA: 通过直接分析推断	18396140	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	18396140	MGI
enables beta-catenin binding	IPI IPI: 通过物理相互作用推断	22723415	MGI
enables chromatin DNA binding	IDA IDA: 通过直接分析推断	32467224	MGI
enables lncRNA binding	IDA IDA: 通过直接分析推断	36662856	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	19816951	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	8940147	MGI
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	16954384	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA-templated transcription	IMP IMP: 通过突变表型推断	23372771	MGI
involved in canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	22723415	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: 通过表达模式推断	20439489	MGI
acts upstream of or within epidermal cell differentiation	IMP IMP: 通过突变表型推断	10431239	MGI
involved in epidermis development	IMP IMP: 通过突变表型推断	32467224	MGI
acts upstream of or within epidermis morphogenesis	IMP IMP: 通过突变表型推断	10431239	MGI
involved in establishment of skin barrier	IMP IMP: 通过突变表型推断	32467224	MGI
acts upstream of or within fat cell differentiation	IMP IMP: 通过突变表型推断	22306741	MGI
involved in fat cell differentiation	IMP IMP: 通过突变表型推断	18396140	MGI
involved in gene expression	IMP IMP: 通过突变表型推断	27208706	MGI
acts upstream of or within glandular epithelial cell differentiation	IMP IMP: 通过突变表型推断	17060454	MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	24129709	MGI
involved in negative regulation of cell migration	IMP IMP: 通过突变表型推断	22491752	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	8702718	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	16954384	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17060454	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	26691508	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	22306741	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	18396140	MGI
acts upstream of or within post-embryonic camera-type eye development	IMP IMP: 通过突变表型推断	17060454	MGI
acts upstream of or within regulation of axon regeneration	IGI IGI: 通过遗传相互作用推断	24129709	MGI
acts upstream of or within regulation of axon regeneration	IMP IMP: 通过突变表型推断	24129709	MGI
acts upstream of or within regulation of blastocyst development	IMP IMP: 通过突变表型推断	29593216	MGI
involved in regulation of cell differentiation	IDA IDA: 通过直接分析推断	19816951	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: 通过遗传相互作用推断	17671182	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19796622	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	36662856	MGI
acts upstream of or within response to retinoic acid	IDA IDA: 通过直接分析推断	18400104	MGI
acts upstream of or within somatic stem cell population maintenance	IDA IDA: 通过直接分析推断	15358627	MGI
involved in stem cell population maintenance	IDA IDA: 通过直接分析推断	19816951	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	22306741	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	24129709	MGI
located in euchromatin	IDA IDA: 通过直接分析推断	22723415	MGI
located in nucleus	IDA IDA: 通过直接分析推断	19796622	MGI
is active in nucleus	IPI IPI: 通过物理相互作用推断	32467224	MGI
part of transcription regulator complex	IDA IDA: 通过直接分析推断	22723415	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

Krueppel-like factor 4

Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)	epithelial zinc finger protein EZF
gut-enriched krueppel-like factor

Klf4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Klf4	Q60793	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	22307056
种属间	Klf4	Q60793	FBXW11	Homo sapiens	Q9UKB1	Anti Tag CoIP	22307056
种属间	Klf4	Q60793	STAU1	Homo sapiens	O95793	Anti Tag CoIP	29374155
种属内	Klf4	Q60793	Mapk3	Mus musculus	Q63844	Y2H	22307056
种属内	Klf4	Q60793	Mapk3	Mus musculus	Q63844	Anti Tag CoIP	22307056

种属间: 跨种属相互作用 种属内: 同种属相互作用

目录号	产品名	作用方式	纯度	Phase
HY-16291	APTO-253		98.86%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12302	Kenpaullone	Inhibitor	98.20%	否
HY-121917	Ro 31-7837		/	否
HY-131923	DAPM	Inhibitor	/	否
HY-16291A	APTO-253 hydrochloride	Inhibitor	/	否
HY-RS07341	KLF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Klf4	NCBI	NCBI:9314

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Klf4 - Kruppel-like factor 4 (gut) Gene

关于 Klf4

功能概要

Klf4 基因产物(1)

Klf4 蛋白互作信息

直系同源

热门区域

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Klf4 - Kruppel-like factor 4 (gut) Gene

关于 Klf4

功能概要

Klf4 基因产物(1)

Klf4 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z