2. Gene
  3. Klf4 - Kruppel-like factor 4 (gut) Gene

Klf4 - Kruppel-like factor 4 (gut) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: EZF; Zie; Gklf

基因 ID: 16600 | 基因类型: protein coding

关于 Klf4

功能概要

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; and beta-catenin binding activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of core promoter binding activity; and transcription, DNA-templated. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of blastocyst development; and regulation of transcription, DNA-templated. Located in cytoplasm; euchromatin; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (Kruppel like factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Klf4 基因产物(1)

mRNA Protein Name
NM_010637.3 NP_034767.2 Krueppel-like factor 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
22306741 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
22723415 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
17130451 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
28262547 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
22723415 MGI
enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity IDA
IDA: 通过直接分析推断
18396140 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
18396140 MGI
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
22723415 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
32467224 MGI
enables lncRNA binding IDA
IDA: 通过直接分析推断
36662856 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19816951 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8940147 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
16954384 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA-templated transcription IMP
IMP: 通过突变表型推断
23372771 MGI
involved in canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
22723415 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
acts upstream of or within epidermal cell differentiation IMP
IMP: 通过突变表型推断
10431239 MGI
involved in epidermis development IMP
IMP: 通过突变表型推断
32467224 MGI
acts upstream of or within epidermis morphogenesis IMP
IMP: 通过突变表型推断
10431239 MGI
involved in establishment of skin barrier IMP
IMP: 通过突变表型推断
32467224 MGI
acts upstream of or within fat cell differentiation IMP
IMP: 通过突变表型推断
22306741 MGI
involved in fat cell differentiation IMP
IMP: 通过突变表型推断
18396140 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
27208706 MGI
acts upstream of or within glandular epithelial cell differentiation IMP
IMP: 通过突变表型推断
17060454 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
24129709 MGI
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
22491752 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
8702718 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16954384 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17060454 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
26691508 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22306741 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18396140 MGI
acts upstream of or within post-embryonic camera-type eye development IMP
IMP: 通过突变表型推断
17060454 MGI
acts upstream of or within regulation of axon regeneration IGI
IGI: 通过遗传相互作用推断
24129709 MGI
acts upstream of or within regulation of axon regeneration IMP
IMP: 通过突变表型推断
24129709 MGI
acts upstream of or within regulation of blastocyst development IMP
IMP: 通过突变表型推断
29593216 MGI
involved in regulation of cell differentiation IDA
IDA: 通过直接分析推断
19816951 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
17671182 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19796622 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
36662856 MGI
acts upstream of or within response to retinoic acid IDA
IDA: 通过直接分析推断
18400104 MGI
acts upstream of or within somatic stem cell population maintenance IDA
IDA: 通过直接分析推断
15358627 MGI
involved in stem cell population maintenance IDA
IDA: 通过直接分析推断
19816951 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22306741 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
24129709 MGI
located in euchromatin IDA
IDA: 通过直接分析推断
22723415 MGI
located in nucleus IDA
IDA: 通过直接分析推断
19796622 MGI
is active in nucleus IPI
IPI: 通过物理相互作用推断
32467224 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
22723415 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

Krueppel-like factor 4

Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)

epithelial zinc finger protein EZF

gut-enriched krueppel-like factor

Klf4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Klf4 Q60793 BTRC Homo sapiens Q9Y297
Anti Tag CoIP
22307056
Cross Klf4 Q60793 FBXW11 Homo sapiens Q9UKB1
Anti Tag CoIP
22307056
Cross Klf4 Q60793 STAU1 Homo sapiens O95793
Anti Tag CoIP
29374155
Intra Klf4 Q60793 Mapk3 Mus musculus Q63844
Y2H
22307056
Intra Klf4 Q60793 Mapk3 Mus musculus Q63844
Anti Tag CoIP
22307056
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-16291 APTO-253 98.86% Phase 1
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12302 Kenpaullone Inhibitor 98.20% 否
HY-121917 Ro 31-7837 / 否
HY-131923 DAPM Inhibitor / 否
HY-16291A APTO-253 hydrochloride Inhibitor / 否
HY-RS07341 KLF4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Klf4 NCBI NCBI:9314
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