FBXW11 - F-box and WD repeat domain containing 11 Gene

中文名称：含 F-box 和 WD 重复结构域 11

种属: Homo sapiens

同用名: Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B; NEDJED

基因 ID: 23291 | 基因类型: protein coding

关于 FBXW11

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:171,861,549-172,006,638 (from NCBI)

This gene has 12 transcripts (splice variants), 238 orthologues, 14 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 22.1), heart (RPKM 11.8) and 25 other tissues.

功能概要

该基因编码 F-box 蛋白家族的一个成员，其特征在于大约 40 个氨基酸基序，即 F-box。 F-box 蛋白构成称为 SCF (SKP1-cullin-F-box) 的泛素蛋白连接酶复合物的四个亚基之一，其在磷酸化依赖性泛素化中发挥作用。 F-box 蛋白分为 3 类：包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和包含不同蛋白质-蛋白质相互作用模块或无可识别基序的 Fbxs。该基因编码的蛋白质属于 Fbws 类，除 F-box 外，还包含多个 WD40 重复序列。该基因至少包含 14 个外显子，其选择性剪接会产生 3 个转录本变体，在存在/不存在两个交替外显子时出现分歧。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

FBXW11 基因产物(10)

mRNA	Protein	Name
NM_001378974.1	NP_001365903.1	F-box/WD repeat-containing protein 11 isoform D
NM_001378975.1	NP_001365904.1	F-box/WD repeat-containing protein 11 isoform E
NM_001378976.1	NP_001365905.1	F-box/WD repeat-containing protein 11 isoform F
NM_001378977.1	NP_001365906.1	F-box/WD repeat-containing protein 11 isoform G
NM_001378978.1	NP_001365907.1	F-box/WD repeat-containing protein 11 isoform G
NM_001378979.1	NP_001365908.1	F-box/WD repeat-containing protein 11 isoform H
NM_001378980.1	NP_001365909.1	F-box/WD repeat-containing protein 11 isoform A
NM_012300.3	NP_036432.2	F-box/WD repeat-containing protein 11 isoform C
NM_033644.3	NP_387448.2	F-box/WD repeat-containing protein 11 isoform B
NM_033645.3	NP_387449.2	F-box/WD repeat-containing protein 11 isoform A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12482991	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: 通过直接分析推断	10321728	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	20347421	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	19966869	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	10644755	GOA
involved in positive regulation of proteolysis	IMP IMP: 通过突变表型推断	16885022	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	10644755	GOA
involved in protein destabilization	IMP IMP: 通过突变表型推断	16885022	GOA
involved in protein polyubiquitination	IDA IDA: 通过直接分析推断	20347421	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	16885022	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of SCF ubiquitin ligase complex	IDA IDA: 通过直接分析推断	16880511	GOA
located in centrosome	IDA IDA: 通过直接分析推断	21399614	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FBXW11 蛋白结构

Beta-TrCP_D

F-box-like

WD40

0
100
200
300
400
500
542 a.a.

蛋白主名

其他名称

F-box/WD repeat-containing protein 11

F-box and WD repeats protein beta-TrCP2

FBXW11 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FBXW11	Q9UKB1	FOXN2	Homo sapiens	P32314	TAP	25609649
种属内	FBXW11	Q9UKB1	FOXN2	Homo sapiens	P32314	Pull Down	25609649
种属内	FBXW11	Q9UKB1	IFNAR1	Homo sapiens	P17181	Anti Tag CoIP	14532120
种属内	FBXW11	Q9UKB1	IFNAR1	Homo sapiens	P17181	Pull Down	14532120
种属内	FBXW11	Q9UKB1	IFNAR1	Homo sapiens	P17181	Anti Bait CoIP	14532120
种属内	FBXW11	Q9UKB1	NFKBIA	Homo sapiens	P25963	TAP	14743216
种属内	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	19159283
种属内	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	TAP	17510365
种属内	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	15070733
种属内	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	19615732
种属内	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	TAP	25609649
种属内	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	TAP	21145461
种属内	FBXW11	Q9UKB1	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	19615732
种属内	FBXW11	Q9UKB1	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	18354482
种属内	FBXW11	Q9UKB1	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	21145461
种属内	FBXW11	Q9UKB1	CUL1	Homo sapiens	Q13616	TAP	21145461
种属内	FBXW11	Q9UKB1	CUL1	Homo sapiens	Q13616	TAP	25609649
种属内	FBXW11	Q9UKB1	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	20708156
种属内	FBXW11	Q9UKB1	MDM2	Homo sapiens	Q00987	Pull Down	20708156
种属内	FBXW11	Q9UKB1	CTNNB1	Homo sapiens	P35222	TAP	25609649
种属内	FBXW11	Q9UKB1	CTNNB1	Homo sapiens	P35222	TAP	17510365
种属内	FBXW11	Q9UKB1	AMER1	Homo sapiens	Q5JTC6	Anti Tag CoIP	33961781
种属内	FBXW11	Q9UKB1	AMER1	Homo sapiens	Q5JTC6	TAP	17510365
种属内	FBXW11	Q9UKB1	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	22682247
种属内	FBXW11	Q9UKB1	INAVA	Homo sapiens	Q3KP66	Anti Tag CoIP	29420262
种属内	FBXW11	Q9UKB1	WEE1	Homo sapiens	P30291	PLA	25241761
种属内	FBXW11	Q9UKB1	WEE1	Homo sapiens	P30291	Anti Tag CoIP	15070733
种属内	FBXW11	Q9UKB1	REST	Homo sapiens	Q13127	Anti Tag CoIP	18354482

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Neurodevelopmental, Jaw, Eye, And Digital Syndrome

NEDJED

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Rift Valley Fever

Rfv - [Rift Valley Fever]

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Neuronopathy, Distal Hereditary Motor, Type Iid

HMN2D	Hmn Iid
Dhmn2d	Distal Hereditary Motor Neuronopathy Type 2d
Distal Hereditary Motor Neuropathy Type Iid	Neuronopathy, Distal Hereditary Motor, Type 2d
Neuropathy, Distal Hereditary Motor, Type Iid	Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant
Distal Spinal Muscular Atrophy With Calf Predominance	Neuronopathy, Distal Hereditary Motor, 2d
Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant	Dhmn Iid
Neuropathy, Motor, Distal, Hereditary, Type 2d

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Brachydactyly

Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii	Distal Hereditary Motor Neuropathy Type 2
Distal Hereditary Motor Neuropathy Type Ii	Hmn Ii
Hmn2	Distal Hereditary Motor Neuronopathy, Type Ii
Distal Spinal Muscular Atrophy Type 2	Dhmn2
Dsma2	Neuropathy, Motor, Distal, Hereditary, Type Ii
Spinal Muscular Atrophy, Jerash Type

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04816	FBXW11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	FBXW11	MGD	MGI:2144023
Bos taurus	FBXW11	VGNC	VGNC:28922
Felis catus	FBXW11	VGNC	VGNC:62200
Canis familiaris	FBXW11	VGNC	VGNC:40792
Rattus norvegicus	FBXW11	RGD	RGD:1309121
Macaca mulatta	FBXW11	VGNC	VGNC:72500

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FBXW11 - F-box and WD repeat domain containing 11 Gene

关于 FBXW11

功能概要

FBXW11 基因产物(10)

FBXW11 蛋白结构

FBXW11 蛋白互作信息

关联疾病

直系同源

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FBXW11 - F-box and WD repeat domain containing 11 Gene

关于 FBXW11

功能概要

FBXW11 基因产物(10)

FBXW11 蛋白结构

FBXW11 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

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