2. Gene
  3. INAVA - innate immunity activator Gene

INAVA - innate immunity activator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：先天免疫激活因子

种属: Homo sapiens

同用名: C1orf106

基因 ID: 55765 | 基因类型: protein coding

关于 INAVA

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,891,531-200,915,742 (from NCBI)

This gene has 7 transcripts (splice variants), 257 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in small intestine (RPKM 20.8), duodenum (RPKM 17.6) and 11 other tissues.

功能概要

参与多个过程，包括含有 2 个信号通路的核苷酸结合活性寡聚化结构域；细胞因子产生的正调节；和细胞内信号转导的正调控。位于细胞质和细胞核中。与炎症性肠病有关 29。[由基因组资源联盟提供，2022 年 4 月]

Involved in several processes, including nucleotide-binding activity oligomerization domain containing 2 signaling pathway; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Located in cytoplasm and nucleus. Implicated in inflammatory bowel disease 29. [provided by Alliance of Genome Resources, Apr 2022]

INAVA 基因产物(4)

mRNA Protein Name
NM_001142569.3 NP_001136041.1 innate immunity activator protein isoform 2
NM_001367289.1 NP_001354218.1 innate immunity activator protein isoform 3
NM_001367290.1 NP_001354219.1 innate immunity activator protein isoform 4
NM_018265.4 NP_060735.4 innate immunity activator protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28436939 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adherens junction maintenance IMP
IMP: 通过突变表型推断
29420262 GOA
involved in innate immune response IMP
IMP: 通过突变表型推断
28436939 GOA
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
IMP: 通过突变表型推断
28436939 GOA
involved in pattern recognition receptor signaling pathway IMP
IMP: 通过突变表型推断
28436939 GOA
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
28436939 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
28436939 GOA
involved in positive regulation of cytokine production involved in immune response IMP
IMP: 通过突变表型推断
28436939 GOA
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
28436939 GOA
involved in positive regulation of interleukin-10 production IMP
IMP: 通过突变表型推断
28436939 GOA
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
28436939 GOA
involved in positive regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
29420262 GOA
involved in positive regulation of stress-activated MAPK cascade IMP
IMP: 通过突变表型推断
28436939 GOA
involved in reactive oxygen species biosynthetic process IMP
IMP: 通过突变表型推断
28436939 GOA
involved in response to muramyl dipeptide IMP
IMP: 通过突变表型推断
28436939 GOA
involved in response to peptidoglycan IMP
IMP: 通过突变表型推断
28436939 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IMP
IMP: 通过突变表型推断
28436939 GOA
located in nucleus IMP
IMP: 通过突变表型推断
28436939 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

INAVA 蛋白结构

DUF3338

DUF3338: Domain of unknown function (DUF3338) (86 - 216)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
蛋白主名 其他名称

innate immunity activator protein

uncharacterized protein C1orf106

INAVA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra INAVA Q3KP66 BTRC Homo sapiens Q9Y297
Anti Tag CoIP
29420262
Intra INAVA Q3KP66 FBXW11 Homo sapiens Q9UKB1
Anti Tag CoIP
29420262
Intra INAVA Q3KP66 CYTH2 Homo sapiens Q99418
Anti Tag CoIP
33961781
Intra INAVA Q3KP66 CYTH2 Homo sapiens Q99418
Anti Tag CoIP
29420262
Intra INAVA Q3KP66 CYTH1 Homo sapiens Q15438
Anti Tag CoIP
33961781
Intra INAVA Q3KP66 CYTH1 Homo sapiens Q15438
Anti Tag CoIP
28514442
Intra INAVA Q3KP66 CYTH1 Homo sapiens Q15438
Anti Tag CoIP
29420262
Intra INAVA Q3KP66 CYTH1 Homo sapiens Q15438
Anti Bait CoIP
29420262
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Inflammatory Bowel Disease 29

IBD29

{Inflammatory Bowel Disease 29}
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Ulcerative Colitis

Colitis Gravis

Left Sided Ulcerative Colitis

Left-Sided Ulcerative Colitis

Idiopathic Proctocolitis

Inflammatory Bowel Disease, Ulcerative Colitis Type

Uc

Colitis Ulcerative

Colitis, Ulcerative

Chronic Left-Sided Ulcerative Colitis

Uc - [Ulcerative Colitis]

Chronic Ulcerative Enteritis

Mucosal Proctocolitis

Ulcerative Mucosal Proctocolitis

Left Hemicolitis
Colitis
Idiopathic Peripheral Autonomic Neuropathy
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06803 INAVA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta INAVA VGNC VGNC:106387
Mus musculus INAVA MGD MGI:1921579
Bos taurus INAVA VGNC VGNC:30192
Felis catus INAVA VGNC VGNC:62920
Rattus norvegicus INAVA RGD RGD:1311892
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