CYTH1 - cytohesin 1 Gene

中文名称：细胞粘附素 1

种属: Homo sapiens

同用名: B2-1; SEC7; PSCD1; D17S811E; CYTOHESIN-1

关于 CYTH1

功能概要

该基因编码的蛋白质是 PSCD 家族的成员。该家族的成员具有相同的结构组织，包括一个 N 端卷曲螺旋基序、一个中央 Sec7 结构域和一个 C 端 pleckstrin 同源 (PH) 结构域。卷曲螺旋基序参与同二聚化，Sec7 结构域包含鸟嘌呤-核苷酸交换蛋白活性，PH 结构域与磷脂相互作用并负责 PSCD 与膜的结合。该家族的成员似乎调节蛋白质分选和膜运输的调节。该基因在自然杀伤细胞和外周 T 细胞中高表达，并调节整合素在淋巴细胞质膜上的粘附性。该基因的假基因已在 X 染色体上定义。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 5 月]

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with Phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]