1. Gene
  2. WEE1 - WEE1 G2 checkpoint kinase Gene

WEE1 - WEE1 G2 checkpoint kinase Gene

中文名称:WEE1 G2 检查点激酶

种属: Homo sapiens

同用名: WEE1A; WEE1hu

基因 ID: 7465 | 基因类型: protein coding

关于 WEE1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,573,670-9,589,985 (from NCBI)

This gene has 10 transcripts (splice variants), 227 orthologues and 8 paralogues. Ubiquitous expression in gall bladder (RPKM 23.7), esophagus (RPKM 19.4) and 22 other tissues.

功能概要

该基因编码一种核蛋白,它是一种属于蛋白激酶 Ser/Thr 家族的酪氨酸激酶。该蛋白催化 CDC2/细胞周期蛋白 B 激酶的抑制性酪氨酸磷酸化,并且似乎通过保护细胞核免受细胞质激活的 CDC2 激酶来协调 DNA 复制和有丝分裂之间的转变。[RefSeq 提供,2008 年 7 月]

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]

WEE1 基因产物(3)

mRNA Protein Name
XM_047427539.1 XP_047283495.1 wee1-like protein kinase isoform X1
NM_003390.4 NP_003381.1 wee1-like protein kinase isoform 1
NM_001143976.2 NP_001137448.1 wee1-like protein kinase isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15070733 GOA
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7743995 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of G2/M transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
7743995 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in nucleus IDA
IDA: 通过直接分析推断
8348613 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

WEE1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (299 - 568)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 646 a.a.
蛋白主名 其他名称

wee1-like protein kinase

WEE1 homolog

WEE1+ homolog

protein kinase

wee1A kinase

WEE1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
WEE1 P30291 BTRC Homo sapiens Q9Y297 15070733
种属内
WEE1 P30291 YWHAZ Homo sapiens P63104 15161933
种属内
WEE1 P30291 FBXW11 Homo sapiens Q9UKB1 15070733
种属内
WEE1 P30291 YWHAE Homo sapiens P62258 36931259
种属内
WEE1 P30291 PLK1 Homo sapiens P53350 15070733
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ciliary Dyskinesia, Primary, 20

Primary Ciliary Dyskinesia 20

CILD20

Primary Ciliary Dyskinesia 20 With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 20, With Or Without Situs Inversus

Ics20

Immotile Cilia Syndrome 20

Dyskinesia, Ciliary, Primary, 20

Vulva Cancer

Vulvar Carcinoma

Malignant Neoplasm Of Vulva

Vulva Carcinoma

Carcinoma Of Vulva

Vulval Cancer

Vulvar Cancer

Vulvar Neoplasms

Ca Vulva

Malignant Tumor Of Vulva

Malignant Vulvar Tumor

Neoplasm Of Vulva

Vulval Neoplasm

Vulvar Neoplasm

Vulvar Tumor

Cancer Of Vulva

Malignant Tumour Of Vulva

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome

BWS

Exomphalos-Macroglossia-Gigantism Syndrome

Emg Syndrome

Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

Emg Abnormality

Wbs

Exomphalos Macroglossia Gigantism Syndrome

Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

Macroglossia Exomphalos Gigantism

Gum Cancer

Malignant Neoplasm Of Gum

Malignant Tumor Of Gum

Malignant Gingival Tumor

Malignant Neoplasm Of Other Sites Of Gum

Malignant Tumour Of Gingiva

Vulva Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Vulva

Vulvar Squamous Cell Carcinoma

Vulvar Epidermoid Carcinoma

Squamous Cell Carcinoma Of The Vulva

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus WEE1 MGD MGI:103075
Felis catus WEE1 VGNC VGNC:67069
Bos taurus WEE1 VGNC VGNC:36930
Macaca mulatta WEE1 VGNC VGNC:78792
Canis familiaris WEE1 VGNC VGNC:48402
Rattus norvegicus WEE1 RGD RGD:1307895
Others WEE1 NCBI