1. Gene
  2. REST - RE1 silencing transcription factor Gene

REST - RE1 silencing transcription factor Gene

中文名称:RE1 沉默转录因子

种属: Homo sapiens

同用名: WT6; XBR; HGF5; NRSF; DFNA27; GINGF5

基因 ID: 5978 | 基因类型: protein coding

关于 REST

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,907,900-56,935,844 (from NCBI)

This gene has 12 transcripts (splice variants), 226 orthologues, 29 paralogues and is associated with 5 phenotypes. Ubiquitous expression in bone marrow (RPKM 9.2), testis (RPKM 8.5) and 25 other tissues.

功能概要

该基因最初被鉴定为抑制非神经元组织中神经元基因的转录抑制因子。然而,根据细胞环境的不同,该基因可以充当致癌基因或肿瘤抑制基因。编码的蛋白质是 Kruppel 型锌指转录因子家族的成员。它通过结合称为神经元限制性消音器元件的 DNA 序列元件来抑制转录。该蛋白质也存在于未分化的神经元祖细胞中,并且认为该阻遏物可能充当神经发生的主要负调节剂。已经描述了选择性剪接的转录物变体。[RefSeq 提供,2018 年 5 月]

This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]

REST 基因产物(3)

mRNA Protein Name
NM_001193508.1 NP_001180437.1 RE1-silencing transcription factor
NM_001363453.2 NP_001350382.1 RE1-silencing transcription factor
NM_005612.5 NP_005603.3 RE1-silencing transcription factor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to electrical stimulus IMP
IMP: 通过突变表型推断
18570921 GOA
involved in cellular response to glucocorticoid stimulus IDA
IDA: 通过直接分析推断
17984088 GOA
involved in cellular response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
20564196 GOA
involved in negative regulation by host of viral transcription IDA
IDA: 通过直接分析推断
17555596 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
7697725 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18570921 GOA
involved in negative regulation of aldosterone biosynthetic process IMP
IMP: 通过突变表型推断
19342457 GOA
involved in negative regulation of amniotic stem cell differentiation IMP
IMP: 通过突变表型推断
20942606 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
20564196 GOA
involved in negative regulation of cortisol biosynthetic process IMP
IMP: 通过突变表型推断
19342457 GOA
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
20564196 GOA
involved in negative regulation of insulin secretion IMP
IMP: 通过突变表型推断
20942606 GOA
involved in negative regulation of mesenchymal stem cell differentiation IMP
IMP: 通过突变表型推断
18570921 GOA
involved in negative regulation of miRNA transcription IMP
IMP: 通过突变表型推断
33108349 GOA
involved in negative regulation of neuron differentiation IDA
IDA: 通过直接分析推断
21258371 GOA
involved in negative regulation of neuron differentiation IMP
IMP: 通过突变表型推断
18570921 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8568247 GOA
involved in nervous system process IMP
IMP: 通过突变表型推断
24670762 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
17984088 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
20564196 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
20564196 GOA
involved in positive regulation of stem cell population maintenance IDA
IDA: 通过直接分析推断
21258371 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11779185 GOA
involved in response to hypoxia IDA
IDA: 通过直接分析推断
27531581 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
24670762 GOA
located in nucleus IDA
IDA: 通过直接分析推断
7697725 GOA
located in nucleus IMP
IMP: 通过突变表型推断
16442230 GOA
part of transcription repressor complex IDA
IDA: 通过直接分析推断
10734093 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

REST 蛋白结构

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (217 - 238)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (290 - 313)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (318 - 343)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (348 - 370)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1097 a.a.
蛋白主名 其他名称

RE1-silencing transcription factor

neural-restrictive silencer factor

REST 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
REST Q13127 KDM5C Homo sapiens P41229
Anti Bait CoIP
17468742
种属内
REST Q13127 HSP90AA1 Homo sapiens P07900
Y2H Pooling
31361762
种属内
REST Q13127 HSP90AA1 Homo sapiens P07900
Y2H
31361762
种属内
REST Q13127 HSP90AA1 Homo sapiens P07900
Anti Bait CoIP
31361762
种属内
REST Q13127 BTRC Homo sapiens Q9Y297
Anti Bait CoIP
18354483
种属内
REST Q13127 BTRC Homo sapiens Q9Y297
Anti Tag CoIP
18354483
种属内
REST Q13127 BTRC Homo sapiens Q9Y297
Pull Down
18354483
种属内
REST Q13127 BTRC Homo sapiens Q9Y297
Anti Bait CoIP
18354482
种属内
REST Q13127 FBXW11 Homo sapiens Q9UKB1
Pull Down
18354483
种属内
REST Q13127 FBXW11 Homo sapiens Q9UKB1
Anti Bait CoIP
18354482
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fibromatosis, Gingival, 5

GINGF5

Ggf5

Fibromatosis, Gingival, Hereditary, 5

Hgf5

Gingival Fibromatosis 5

Wilms Tumor 6

WT6

Wilms Tumor 6, Susceptibility To

Susceptibility To Wilms Tumor 6

Wilms Tumor, Susceptibility To

Nephroblastoma

Deafness, Autosomal Dominant 27

DFNA27

Autosomal Dominant Nonsyndromic Deafness 27

Autosomal Dominant Deafness 27

Deafness, Autosomal Dominant, 27

Gingival Fibromatosis

Hereditary Gingival Fibromatosis

Hereditary Gingival Hyperplasia

Autosomal Dominant Gingival Fibromatosis

Autosomal Dominant Gingival Hyperplasia

Fibromatosis, Gingival, Hereditary

Fibromatosis, Gingival

Fibromatosis, Gingival, 1

GINGF1

Ggf1

Fibromatosis, Gingival, Hereditary

Hgf

Hereditary Gingival Fibromatosis

Gingf

Gingival Fibromatosis, 1

Fibromatosis Gingival, Hereditary, 1

Hgf1

Hereditary Gingival Fibromatosis, 1

Wilms Tumor Predisposition
Aging
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor

Fibromatosis
Prostate Neuroendocrine Neoplasm

Neuroendocrine Tumor Of The Prostate

Ischemia

Acute Coronary Syndrome

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Rett Syndrome

Atypical Rett Syndrome

RTT

Rett Disorder

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Preserved Speech Variant

Rett Syndrome, Atypical

Rett'S Disorder

Rett Syndrome Variant

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant

Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus REST MGD MGI:104897
Rattus norvegicus REST RGD RGD:621069
Macaca mulatta REST VGNC VGNC:76898
Canis familiaris REST VGNC VGNC:45480
Macaca fascicularis REST NCBI NCBI:102116020
Others REST NCBI