RPL7A - ribosomal protein L7a Gene

中文名称：核糖体蛋白 L7a

种属: Homo sapiens

同用名: L7A; TRUP; SURF3

关于 RPL7A

功能概要

细胞质核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 60S 亚基的一个组成部分。该蛋白属于核糖体蛋白 L7AE 家族。它可以与核激素受体的一个子类相互作用，包括甲状腺激素受体，并通过阻止它们与其 DNA 反应元件结合来抑制它们反式激活的能力。该基因包含在过剩基因簇中，这是一组非常紧密连锁的基因，它们不具有序列相似性。它与 U24、U36a、U36b 和 U36c 小核仁 RNA 基因共转录，这些基因分别位于其第二、第五、第四和第六个内含子中。该基因与 Trk 原癌基因重排形成嵌合癌基因 trk-2h，该基因编码一种癌蛋白，该癌蛋白由核糖体蛋白 L7a 的 N 末端组成，融合到 Trk 的受体酪氨酸激酶结构域。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供，2008 年 7 月]

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including Thyroid Hormone Receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the Trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of Trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]